8P8H
 
 | | Crystal structure of HHD2 domain of hRTEL1 | | Descriptor: | Regulator of telomere elongation helicase 1 | | Authors: | Hegde, R.P, Kanade, M, Cortone, G, Graewert, M, Longo, A, Gonzalez, A, Chaves-Arquero, B, Blanco, F.J, Napolitano, L.M.R, Onesti, S. | | Deposit date: | 2023-06-01 | | Release date: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of HHD2 domain of hRTEL1
To Be Published
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6Y4L
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1BY9
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6Z3W
 | | Human ER membrane protein complex | | Descriptor: | ER membrane protein complex subunit 1,ER membrane protein complex subunit 1,ER membrane protein complex subunit 1,ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ER membrane protein complex subunit 2, ... | | Authors: | Hegde, R.S, O'Donnell, J.P. | | Deposit date: | 2020-05-22 | | Release date: | 2020-07-15 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (6.4 Å) | | Cite: | The architecture of EMC reveals a path for membrane protein insertion.
Elife, 9, 2020
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4JHM
 | | Crystal structure of a putative mandelate racemase/muconate lactonizing enzyme from Pseudovibrio sp. | | Descriptor: | Mandelate racemase / muconate lactonizing enzyme, C-terminal domain protein | | Authors: | Hegde, R.P, Toro, R, Burley, S.K, Almo, S.C, Ramagopal, U.A, New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2013-03-05 | | Release date: | 2013-05-01 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of a putative mandelate racemase/muconate lactonizing enzyme from Pseudovibrio sp.
To be published
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4HN8
 | | Crystal structure of a putative D-glucarate dehydratase from Pseudomonas mendocina ymp | | Descriptor: | D-glucarate dehydratase, GLYCEROL | | Authors: | Hegde, R.P, Toro, R, Burley, S.K, Almo, S.C, Ramagopal, U.A, New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2012-10-19 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of a putative D-glucarate dehydratase from Pseudomonas mendocina ymp
To be published
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4HYR
 | | Structure of putative Glucarate dehydratase from Acidaminococcus sp. D21 with unusual static disorder | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | | Authors: | Hegde, R.P, Toro, R, Burley, S.K, Almo, S.C, Ramagopal, U.A, New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2012-11-14 | | Release date: | 2013-02-13 | | Last modified: | 2021-02-10 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Structure of putative Glucarate dehydratase from Acidaminococcus sp. D21 with unusual static disorder
To be published
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1JJH
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3BY2
 | | Norwalk P polypeptide (228-523) | | Descriptor: | 58 kd capsid protein | | Authors: | Hegde, R, Bu, W. | | Deposit date: | 2008-01-15 | | Release date: | 2008-04-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for the receptor binding specificity of Norwalk virus.
J.Virol., 82, 2008
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3BY1
 | | Unliganded Norvalk Virus P domain | | Descriptor: | 58 kd capsid protein | | Authors: | Hegde, R, Bu, W. | | Deposit date: | 2008-01-15 | | Release date: | 2008-04-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Structural basis for the receptor binding specificity of Norwalk virus.
J.Virol., 82, 2008
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2BOP
 | | CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET | | Descriptor: | DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*TP*CP*G )-3'), PROTEIN (E2), YTTERBIUM (III) ION | | Authors: | Hegde, R.S, Grossman, S.R, Laimins, L.A, Sigler, P.B. | | Deposit date: | 1994-01-13 | | Release date: | 1994-01-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target.
Nature, 359, 1992
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3D26
 | | Norwalk P domain A-trisaccharide complex | | Descriptor: | 58 kd capsid protein, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)]beta-D-galactopyranose | | Authors: | Hegde, R, Bu, W. | | Deposit date: | 2008-05-07 | | Release date: | 2008-06-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for the receptor binding specificity of Norwalk virus.
J.Virol., 82, 2008
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2F61
 | | Crystal structure of partially deglycosylated acid beta-glucosidase | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid beta-glucosidase, ... | | Authors: | Hegde, R.S, Grabowski, G. | | Deposit date: | 2005-11-28 | | Release date: | 2005-12-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Analyses of Variant Acid beta-Glucosidases: EFFECTS OF GAUCHER DISEASE MUTATIONS.
J.Biol.Chem., 281, 2006
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5LZW
 | | Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA. | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. | | Deposit date: | 2016-10-02 | | Release date: | 2016-11-30 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
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4XWO
 | | Structure of Get3 bound to the transmembrane domain of Sec22 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase GET3, ... | | Authors: | Mateja, A, Paduch, M, Chang, H.-Y, Szydlowska, A, Kossiakoff, A.A, Hegde, R.S, Keenan, R.J. | | Deposit date: | 2015-01-29 | | Release date: | 2015-03-25 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.
Science, 347, 2015
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1GRL
 | | THE CRYSTAL STRUCTURE OF THE BACTERIAL CHAPERONIN GROEL AT 2.8 ANGSTROMS | | Descriptor: | GROEL (HSP60 CLASS) | | Authors: | Braig, K, Otwinowski, Z, Hegde, R, Boisvert, D.C, Joachimiak, A, Horwich, A.L, Sigler, P.B. | | Deposit date: | 1995-03-07 | | Release date: | 1995-10-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The crystal structure of the bacterial chaperonin GroEL at 2.8 A.
Nature, 371, 1994
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2WOJ
 | | ADP-AlF4 complex of S. cerevisiae GET3 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATPASE GET3, MAGNESIUM ION, ... | | Authors: | Mateja, A, Szlachcic, A, Downing, M.E, Dobosz, M, Mariappan, M, Hegde, R.S, Keenan, R.J. | | Deposit date: | 2009-07-26 | | Release date: | 2009-08-11 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.994 Å) | | Cite: | The Structural Basis of Tail-Anchored Membrane Protein Recognition by Get3.
Nature, 461, 2009
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8BPO
 | | Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 (TTC5) and S-phase Cyclin A Associated Protein residing in the ER (SCAPER) | | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Hopfler, M, Absmeier, E, Passmore, L.A, Hegde, R.S. | | Deposit date: | 2022-11-17 | | Release date: | 2023-07-05 | | Last modified: | 2023-07-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation.
Mol.Cell, 83, 2023
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4MB6
 | | Crystal structure of adenine phosphoribosyltransferase from Yersinia pseudotuberculosis. | | Descriptor: | Adenine phosphoribosyltransferase, SODIUM ION | | Authors: | Pavithra, G.C, Kim, J, Hegde, R.P, Almo, S.C, Ramagopal, U.A, New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2013-08-19 | | Release date: | 2013-09-04 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Crystal structure of adenine phosphoribosyltransferase from Yersinia pseudotuberculosis
To be published
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4XVU
 | | Structure of Get3 bound to the transmembrane domain of Nyv1 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATPase GET3, Antibody heavy chain, ... | | Authors: | Mateja, A, Paduch, M, Chang, H.-Y, Szydlowska, A, Kossiakoff, A.A, Hegde, R.S, Keenan, R.J. | | Deposit date: | 2015-01-28 | | Release date: | 2015-03-18 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.
Science, 347, 2015
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4XTR
 | | Structure of Get3 bound to the transmembrane domain of Pep12 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase GET3, ... | | Authors: | Mateja, A, Paduch, M, Chang, H.-Y, Szydlowska, A, Kossiakoff, A.A, Hegde, R.S, Keenan, R.J. | | Deposit date: | 2015-01-23 | | Release date: | 2015-03-18 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.
Science, 347, 2015
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1F9F
 | | CRYSTAL STRUCTURE OF THE HPV-18 E2 DNA-BINDING DOMAIN | | Descriptor: | Regulatory protein E2, SULFATE ION | | Authors: | Kim, S.S, Tam, J, Wang, A.F, Hegde, R. | | Deposit date: | 2000-07-10 | | Release date: | 2000-11-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The structural basis of DNA target discrimination by papillomavirus E2 proteins.
J.Biol.Chem., 275, 2000
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2OQS
 | | Structure of the hDLG/SAP97 PDZ2 in complex with HPV-18 papillomavirus E6 peptide | | Descriptor: | C-terminal HPV-18 E6 peptide, Disks large homolog 1 | | Authors: | Liu, Y, Baleja, J.D, Henry, G.D, Hegde, R.S. | | Deposit date: | 2007-02-01 | | Release date: | 2007-09-04 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the hDlg/SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein.
Biochemistry, 46, 2007
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1SBX
 | | Crystal structure of the Dachshund-homology domain of human SKI | | Descriptor: | Ski oncogene | | Authors: | Wilson, J.J, Malakhova, M, Zhang, R, Joachimiak, A, Hegde, R.S. | | Deposit date: | 2004-02-11 | | Release date: | 2004-05-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal Structure of the Dachshund Homology Domain of human SKI
Structure, 12, 2004
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7QWR
 | | Structure of the ribosome-nascent chain containing an ER signal sequence in complex with NAC | | Descriptor: | 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Jomaa, A, Gamerdinger, M, Hsieh, H, Wallisch, A, Chandrasekaran, V, Ulusoy, Z, Scaiola, A, Hegde, R, Shan, S, Ban, N, Deuerling, E. | | Deposit date: | 2022-01-25 | | Release date: | 2022-03-09 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.
Science, 375, 2022
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