5JHG

Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11

Summary for 5JHG

• Entry DOI: 10.2210/pdb5jhg/pdb
• Related: 5JHH
• Descriptor: Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, GLYCEROL, ... (4 entities in total)
• Functional Keywords: rhoa-arhrhogef11 complex, target-based pharmaceutical design, signaling protein-transcription complex, signaling protein/transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : O15085; Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
• Total number of polymer chains: 4
• Total formula weight: 127118.60

Authors

Wang, R.,Chen, Q.,Zhang, H.,Yan, Z.,Li, J.,Miao, L.,Wang, F. (deposition date: 2016-04-21, release date: 2017-04-26, Last modification date: 2024-03-20)

• Primary citation: Wang, R.,Yan, Z.,Lv, Z.,Ma, L.,Wang, F.,Li, J.,Miao, L.; Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)