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5JHG

Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11

Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0007186biological_processG protein-coupled receptor signaling pathway
A0007266biological_processRho protein signal transduction
B0000166molecular_functionnucleotide binding
B0000281biological_processmitotic cytokinesis
B0000902biological_processcell morphogenesis
B0001764biological_processneuron migration
B0001822biological_processkidney development
B0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
B0002363biological_processalpha-beta T cell lineage commitment
B0003100biological_processregulation of systemic arterial blood pressure by endothelin
B0003189biological_processaortic valve formation
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0006357biological_processregulation of transcription by RNA polymerase II
B0007010biological_processcytoskeleton organization
B0007155biological_processcell adhesion
B0007160biological_processcell-matrix adhesion
B0007264biological_processsmall GTPase-mediated signal transduction
B0007266biological_processRho protein signal transduction
B0007519biological_processskeletal muscle tissue development
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010812biological_processnegative regulation of cell-substrate adhesion
B0010975biological_processregulation of neuron projection development
B0016020cellular_componentmembrane
B0016477biological_processcell migration
B0016787molecular_functionhydrolase activity
B0017022molecular_functionmyosin binding
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0021795biological_processcerebral cortex cell migration
B0021861biological_processforebrain radial glial cell differentiation
B0030027cellular_componentlamellipodium
B0030036biological_processactin cytoskeleton organization
B0030054cellular_componentcell junction
B0030154biological_processcell differentiation
B0030334biological_processregulation of cell migration
B0030335biological_processpositive regulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030521biological_processandrogen receptor signaling pathway
B0030667cellular_componentsecretory granule membrane
B0031122biological_processcytoplasmic microtubule organization
B0031982cellular_componentvesicle
B0032154cellular_componentcleavage furrow
B0032467biological_processpositive regulation of cytokinesis
B0032587cellular_componentruffle membrane
B0032956biological_processregulation of actin cytoskeleton organization
B0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
B0033688biological_processregulation of osteoblast proliferation
B0034329biological_processcell junction assembly
B0034446biological_processsubstrate adhesion-dependent cell spreading
B0035385biological_processRoundabout signaling pathway
B0036089biological_processcleavage furrow formation
B0038027biological_processapolipoprotein A-I-mediated signaling pathway
B0042476biological_processodontogenesis
B0042995cellular_componentcell projection
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043149biological_processstress fiber assembly
B0043197cellular_componentdendritic spine
B0043296cellular_componentapical junction complex
B0043297biological_processapical junction assembly
B0043366biological_processbeta selection
B0043542biological_processendothelial cell migration
B0043931biological_processossification involved in bone maturation
B0044319biological_processwound healing, spreading of cells
B0045198biological_processestablishment of epithelial cell apical/basal polarity
B0045666biological_processpositive regulation of neuron differentiation
B0045792biological_processnegative regulation of cell size
B0046638biological_processpositive regulation of alpha-beta T cell differentiation
B0050919biological_processnegative chemotaxis
B0051301biological_processcell division
B0051496biological_processpositive regulation of stress fiber assembly
B0051893biological_processregulation of focal adhesion assembly
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060193biological_processpositive regulation of lipase activity
B0061430biological_processbone trabecula morphogenesis
B0070062cellular_componentextracellular exosome
B0070507biological_processregulation of microtubule cytoskeleton organization
B0071222biological_processcellular response to lipopolysaccharide
B0071345biological_processcellular response to cytokine stimulus
B0071526biological_processsemaphorin-plexin signaling pathway
B0071803biological_processpositive regulation of podosome assembly
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0071944cellular_componentcell periphery
B0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
B0090307biological_processmitotic spindle assembly
B0090324biological_processnegative regulation of oxidative phosphorylation
B0097049biological_processmotor neuron apoptotic process
B0097498biological_processendothelial tube lumen extension
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0101003cellular_componentficolin-1-rich granule membrane
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B1902766biological_processskeletal muscle satellite cell migration
B1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
B1903673biological_processmitotic cleavage furrow formation
B1904695biological_processpositive regulation of vascular associated smooth muscle contraction
B1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
B1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
B1990869biological_processcellular response to chemokine
B2000177biological_processregulation of neural precursor cell proliferation
B2000406biological_processpositive regulation of T cell migration
B2000672biological_processnegative regulation of motor neuron apoptotic process
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0007186biological_processG protein-coupled receptor signaling pathway
E0007266biological_processRho protein signal transduction
F0000166molecular_functionnucleotide binding
F0000281biological_processmitotic cytokinesis
F0000902biological_processcell morphogenesis
F0001764biological_processneuron migration
F0001822biological_processkidney development
F0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
F0002363biological_processalpha-beta T cell lineage commitment
F0003100biological_processregulation of systemic arterial blood pressure by endothelin
F0003189biological_processaortic valve formation
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005768cellular_componentendosome
F0005789cellular_componentendoplasmic reticulum membrane
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0005938cellular_componentcell cortex
F0006357biological_processregulation of transcription by RNA polymerase II
F0007010biological_processcytoskeleton organization
F0007155biological_processcell adhesion
F0007160biological_processcell-matrix adhesion
F0007264biological_processsmall GTPase-mediated signal transduction
F0007266biological_processRho protein signal transduction
F0007519biological_processskeletal muscle tissue development
F0009898cellular_componentcytoplasmic side of plasma membrane
F0010812biological_processnegative regulation of cell-substrate adhesion
F0010975biological_processregulation of neuron projection development
F0016020cellular_componentmembrane
F0016477biological_processcell migration
F0016787molecular_functionhydrolase activity
F0017022molecular_functionmyosin binding
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0021795biological_processcerebral cortex cell migration
F0021861biological_processforebrain radial glial cell differentiation
F0030027cellular_componentlamellipodium
F0030036biological_processactin cytoskeleton organization
F0030054cellular_componentcell junction
F0030154biological_processcell differentiation
F0030334biological_processregulation of cell migration
F0030335biological_processpositive regulation of cell migration
F0030425cellular_componentdendrite
F0030496cellular_componentmidbody
F0030521biological_processandrogen receptor signaling pathway
F0030667cellular_componentsecretory granule membrane
F0031122biological_processcytoplasmic microtubule organization
F0031982cellular_componentvesicle
F0032154cellular_componentcleavage furrow
F0032467biological_processpositive regulation of cytokinesis
F0032587cellular_componentruffle membrane
F0032956biological_processregulation of actin cytoskeleton organization
F0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
F0033688biological_processregulation of osteoblast proliferation
F0034329biological_processcell junction assembly
F0034446biological_processsubstrate adhesion-dependent cell spreading
F0035385biological_processRoundabout signaling pathway
F0036089biological_processcleavage furrow formation
F0038027biological_processapolipoprotein A-I-mediated signaling pathway
F0042476biological_processodontogenesis
F0042995cellular_componentcell projection
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0043149biological_processstress fiber assembly
F0043197cellular_componentdendritic spine
F0043296cellular_componentapical junction complex
F0043297biological_processapical junction assembly
F0043366biological_processbeta selection
F0043542biological_processendothelial cell migration
F0043931biological_processossification involved in bone maturation
F0044319biological_processwound healing, spreading of cells
F0045198biological_processestablishment of epithelial cell apical/basal polarity
F0045666biological_processpositive regulation of neuron differentiation
F0045792biological_processnegative regulation of cell size
F0046638biological_processpositive regulation of alpha-beta T cell differentiation
F0050919biological_processnegative chemotaxis
F0051301biological_processcell division
F0051496biological_processpositive regulation of stress fiber assembly
F0051893biological_processregulation of focal adhesion assembly
F0060071biological_processWnt signaling pathway, planar cell polarity pathway
F0060193biological_processpositive regulation of lipase activity
F0061430biological_processbone trabecula morphogenesis
F0070062cellular_componentextracellular exosome
F0070507biological_processregulation of microtubule cytoskeleton organization
F0071222biological_processcellular response to lipopolysaccharide
F0071345biological_processcellular response to cytokine stimulus
F0071526biological_processsemaphorin-plexin signaling pathway
F0071803biological_processpositive regulation of podosome assembly
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0071944cellular_componentcell periphery
F0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
F0090307biological_processmitotic spindle assembly
F0090324biological_processnegative regulation of oxidative phosphorylation
F0097049biological_processmotor neuron apoptotic process
F0097498biological_processendothelial tube lumen extension
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0099159biological_processregulation of modification of postsynaptic structure
F0101003cellular_componentficolin-1-rich granule membrane
F1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
F1902766biological_processskeletal muscle satellite cell migration
F1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
F1903673biological_processmitotic cleavage furrow formation
F1904695biological_processpositive regulation of vascular associated smooth muscle contraction
F1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
F1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
F1990869biological_processcellular response to chemokine
F2000177biological_processregulation of neural precursor cell proliferation
F2000406biological_processpositive regulation of T cell migration
F2000672biological_processnegative regulation of motor neuron apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue GOL A 1101
ChainResidue
AILE788
ASER791
ATRP792
AALA795
AARG816

site_idAC2
Number of Residues3
Detailsbinding site for residue GOL A 1102
ChainResidue
AHIS968
BGLU102
BHIS105

site_idAC3
Number of Residues6
Detailsbinding site for residue GOL B 201
ChainResidue
BCYS16
BGLY17
BLYS18
BTHR19
BCYS20
BALA15

site_idAC4
Number of Residues4
Detailsbinding site for residue GOL E 1101
ChainResidue
ESER791
ETRP792
EALA795
EARG816

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues378
DetailsDomain: {"description":"DH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00062","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues34
DetailsRegion: {"description":"Switch II region; involved in RAP1GDS1 isoform 2 binding","evidences":[{"source":"PubMed","id":"30190425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZHX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues16
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10748207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12777804","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues26
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) ADP-ribosylasparagine; by botulinum toxin","evidences":[{"source":"PubMed","id":"1328215","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"5-glutamyl serotonin","evidences":[{"source":"UniProtKB","id":"Q9QUI0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23871831","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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