7QOX
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![BU of 7qox by Molmil](/molmil-images/mine/7qox) | Factor XI and Plasma Kallikrein apple domain structures reveals different kininogen bound complexes | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... | Authors: | Li, C, Awital, B, Wong, S, Dreveny, I, Meijers, J, Emsley, J. | Deposit date: | 2021-12-29 | Release date: | 2023-01-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI. J Thromb Haemost, 17, 2019
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7QOT
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![BU of 7qot by Molmil](/molmil-images/mine/7qot) | Factor XI and Plasma Kallikrein apple domain structures reveals different kininogen bound complexes | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XIa heavy chain, Kininogen-1 light chain, ... | Authors: | Li, C, Awital, B, Wong, S, Dreveny, I, Meijers, J, Emsley, J. | Deposit date: | 2021-12-28 | Release date: | 2023-01-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.24 Å) | Cite: | Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI. J Thromb Haemost, 17, 2019
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7WGE
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![BU of 7wge by Molmil](/molmil-images/mine/7wge) | Human NLRP1 complexed with thioredoxin | Descriptor: | MAGNESIUM ION, NACHT, LRR and PYD domains-containing protein 1, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2021-12-28 | Release date: | 2023-07-05 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature, 622, 2023
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7WFY
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![BU of 7wfy by Molmil](/molmil-images/mine/7wfy) | |
7WG0
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![BU of 7wg0 by Molmil](/molmil-images/mine/7wg0) | |
7WF7
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![BU of 7wf7 by Molmil](/molmil-images/mine/7wf7) | Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to S1P | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | He, Y, Xu, Z. | Deposit date: | 2021-12-26 | Release date: | 2022-01-05 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18, 2022
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7WEX
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![BU of 7wex by Molmil](/molmil-images/mine/7wex) | |
7WEZ
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![BU of 7wez by Molmil](/molmil-images/mine/7wez) | |
7WF0
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![BU of 7wf0 by Molmil](/molmil-images/mine/7wf0) | The 0.83 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with nervonic acid | Descriptor: | (15E)-TETRACOS-15-ENOIC ACID, Fatty acid-binding protein, heart, ... | Authors: | Sugiyama, S, Kakinouchi, K, Nakano, R, Matsuoka, S, Tsuchikawa, H, Sonoyama, M, Inoue, Y, Hayashi, F, Murata, M. | Deposit date: | 2021-12-24 | Release date: | 2022-12-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (0.83 Å) | Cite: | The 0.83 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with nervonic acid To Be Published
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7TCH
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![BU of 7tch by Molmil](/molmil-images/mine/7tch) | BceAB E169Q variant ATP-bound conformation | Descriptor: | 4-amino-4-deoxy-1-O-[(S)-hydroxy{[(2E,6E,10Z,14Z,18Z,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-yl]oxy}phosphoryl]-alpha-L-arabinopyranose, ADENOSINE-5'-TRIPHOSPHATE, Bacitracin export ATP-binding protein BceA, ... | Authors: | George, N.L, Orlando, B.J. | Deposit date: | 2021-12-23 | Release date: | 2022-04-06 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Conformational snapshots of the bacitracin sensing and resistance transporter BceAB. Proc.Natl.Acad.Sci.USA, 119, 2022
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7TCG
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![BU of 7tcg by Molmil](/molmil-images/mine/7tcg) | BceAB nucleotide-free conformation | Descriptor: | 4-amino-4-deoxy-1-O-[(S)-hydroxy{[(2E,6E,10Z,14Z,18Z,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-yl]oxy}phosphoryl]-alpha-L-arabinopyranose, Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB | Authors: | George, N.L, Orlando, B.J. | Deposit date: | 2021-12-23 | Release date: | 2022-04-06 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Conformational snapshots of the bacitracin sensing and resistance transporter BceAB. Proc.Natl.Acad.Sci.USA, 119, 2022
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7TCE
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![BU of 7tce by Molmil](/molmil-images/mine/7tce) | Crystal structure of delta sub IV Rhodobacter Sphaeroides bc1 with the antimalarial drug atovaquone. | Descriptor: | 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione, Cytochrome b, ... | Authors: | Esser, L, Xia, D, Zhou, F. | Deposit date: | 2021-12-23 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.85 Å) | Cite: | Crystal structure of delta sub IV Rhodobacter Sphaeroides bc1 with the antimalarial drug atovaquone. To Be Published
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7QO6
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![BU of 7qo6 by Molmil](/molmil-images/mine/7qo6) | 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the s2 state | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, ... | Authors: | Hung, K.Y.S, Klumpe, S, Eisele, M.R, Elsasser, S, Geng, T.T, Cheng, T.C, Joshi, T, Rudack, T, Sakata, E, Finley, D. | Deposit date: | 2021-12-23 | Release date: | 2022-03-16 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (6.3 Å) | Cite: | Allosteric control of Ubp6 and the proteasome via a bidirectional switch. Nat Commun, 13, 2022
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7QO5
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![BU of 7qo5 by Molmil](/molmil-images/mine/7qo5) | 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, ... | Authors: | Hung, K.Y.S, Klumpe, S, Eisele, M.R, Elsasser, S, Geng, T.T, Cheng, T.C, Joshi, T, Rudack, T, Sakata, E, Finley, D. | Deposit date: | 2021-12-23 | Release date: | 2022-03-16 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | Allosteric control of Ubp6 and the proteasome via a bidirectional switch. Nat Commun, 13, 2022
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7QO4
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![BU of 7qo4 by Molmil](/molmil-images/mine/7qo4) | 26S proteasome WT-Ubp6-UbVS complex in the si state (ATPases, Rpn1, Ubp6, and UbVS) | Descriptor: | 26S proteasome regulatory subunit RPN1, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Hung, K.Y.S, Klumpe, S, Eisele, M.R, Elsasser, S, Geng, T.T, Cheng, C, Joshi, T, Rudack, T, Sakata, E, Finley, D. | Deposit date: | 2021-12-23 | Release date: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Allosteric control of Ubp6 and the proteasome via a bidirectional switch. Nat Commun, 13, 2022
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7TBW
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![BU of 7tbw by Molmil](/molmil-images/mine/7tbw) | The structure of ATP-bound ABCA1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Sun, Y, Li, X. | Deposit date: | 2021-12-22 | Release date: | 2022-01-26 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states. Nat Cardiovasc Res, 1, 2022
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7TC0
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![BU of 7tc0 by Molmil](/molmil-images/mine/7tc0) | The structure of human ABCA1 in digitonin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-binding cassette, ... | Authors: | Sun, Y, Li, X. | Deposit date: | 2021-12-22 | Release date: | 2022-01-26 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states. Nat Cardiovasc Res, 1, 2022
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7TBY
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![BU of 7tby by Molmil](/molmil-images/mine/7tby) | The structure of human ABCA1 in nanodisc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-binding cassette, ... | Authors: | Sun, Y, Li, X. | Deposit date: | 2021-12-22 | Release date: | 2022-01-26 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states. Nat Cardiovasc Res, 1, 2022
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7TBZ
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![BU of 7tbz by Molmil](/molmil-images/mine/7tbz) | The structure of ABCA1 Y482C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-binding cassette, ... | Authors: | Sun, Y, Li, X. | Deposit date: | 2021-12-22 | Release date: | 2022-01-26 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states. Nat Cardiovasc Res, 1, 2022
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7WE5
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![BU of 7we5 by Molmil](/molmil-images/mine/7we5) | The 0.87 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with oleic acid | Descriptor: | Fatty acid-binding protein, heart, HEXAETHYLENE GLYCOL, ... | Authors: | Sugiyama, S, Matsuoka, S, Tsuchikawa, H, Sonoyama, M, Inoue, Y, Hayashi, F, Murata, M. | Deposit date: | 2021-12-22 | Release date: | 2022-12-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (0.87 Å) | Cite: | The 0.90 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with linoleic acid To Be Published
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7QNN
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![BU of 7qnn by Molmil](/molmil-images/mine/7qnn) | Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with inhibitor (surface entropy reduction mutant) | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Steroid C26-monooxygenase, ethyl 1-(cyclopentylmethyl)-5-pyridin-4-yl-indole-2-carboxylate | Authors: | Snee, M, Tunnicliffe, R, Leys, D, Levy, C, Katariya, M. | Deposit date: | 2021-12-21 | Release date: | 2022-12-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis. Chemistry, 29, 2023
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7TAN
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![BU of 7tan by Molmil](/molmil-images/mine/7tan) | Structure of VRK1 C-terminal tail bound to nucleosome core particle | Descriptor: | Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, Histone H3.2, ... | Authors: | Spangler, C.J, Budziszewski, G.R, McGinty, R.K. | Deposit date: | 2021-12-21 | Release date: | 2022-05-04 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Multivalent DNA and nucleosome acidic patch interactions specify VRK1 mitotic localization and activity. Nucleic Acids Res., 50, 2022
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7TBC
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![BU of 7tbc by Molmil](/molmil-images/mine/7tbc) | Crystal structure of Plasmepsin X from Plasmodium falciparum in complex with WM382 | Descriptor: | (4R)-4-[(2E)-4,4-diethyl-2-imino-6-oxo-1,3-diazinan-1-yl]-N-[(4S)-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-3,4-dihydro-2H-1-benzopyran-6-carboxamide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Christensen, J.B, Hodder, A.N, Scally, S.W, Cowman, A.F. | Deposit date: | 2021-12-21 | Release date: | 2022-05-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax. Structure, 30, 2022
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7TBE
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![BU of 7tbe by Molmil](/molmil-images/mine/7tbe) | Crystal structure of Plasmepsin X from Plasmodium vivax in complex with WM4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(R)-[(2E,4S)-2-imino-4-methyl-6-oxo-4-(propan-2-yl)-1,3-diazinan-1-yl](phenyl)methyl]-N-[(1S)-1-phenylethyl]benzamide, Plasmepsin X, ... | Authors: | Hodder, A.N, Christensen, J.B, Scally, S.W, Cowman, A.F. | Deposit date: | 2021-12-21 | Release date: | 2022-05-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax. Structure, 30, 2022
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7TBD
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![BU of 7tbd by Molmil](/molmil-images/mine/7tbd) | Crystal structure of Plasmepsin X from Plasmodium vivax in complex with WM382 | Descriptor: | (4R)-4-[(2E)-4,4-diethyl-2-imino-6-oxo-1,3-diazinan-1-yl]-N-[(4S)-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-3,4-dihydro-2H-1-benzopyran-6-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Hodder, A.N, Christensen, J.B, Scally, S.W, Cowman, A.F. | Deposit date: | 2021-12-21 | Release date: | 2022-05-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax. Structure, 30, 2022
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