7WF7
Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to S1P
Summary for 7WF7
Entry DOI | 10.2210/pdb7wf7/pdb |
EMDB information | 32461 |
Descriptor | Sphingosine 1-phosphate receptor 1, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total) |
Functional Keywords | gpcr, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 155793.22 |
Authors | |
Primary citation | Xu, Z.,Ikuta, T.,Kawakami, K.,Kise, R.,Qian, Y.,Xia, R.,Sun, M.X.,Zhang, A.,Guo, C.,Cai, X.H.,Huang, Z.,Inoue, A.,He, Y. Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18:281-288, 2022 Cited by PubMed: 34937912DOI: 10.1038/s41589-021-00930-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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