8HTI
| Human Consensus Olfactory Receptor OR52c in Complex with Octanoic Acid (OCA) and G Protein | Descriptor: | Consensus Olfactory Receptor OR52c, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Choi, C.W, Bae, J, Choi, H.-J, Kim, J. | Deposit date: | 2022-12-21 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family. Nat Commun, 14, 2023
|
|
8IES
| Cryo-EM structure of ATP13A2 in the E1P-ADP state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Conformational cycle of human polyamine transporter ATP13A2. Nat Commun, 14, 2023
|
|
8IEM
| Cryo-EM structure of ATP13A2 in the E2P state | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Conformational cycle of human polyamine transporter ATP13A2. Nat Commun, 14, 2023
|
|
8I8R
| Cryo-EM Structure of OmpC3-MlaA Complex in MSP2N2 Nanodiscs | Descriptor: | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Intermembrane phospholipid transport system lipoprotein MlaA, Outer membrane porin C | Authors: | Yeow, J, Luo, M, Chng, S.S. | Deposit date: | 2023-02-05 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Molecular mechanism of phospholipid transport at the bacterial outer membrane interface. Nat Commun, 14, 2023
|
|
8IER
| |
8IEN
| Cryo-EM structure of ATP13A2 in the E2-Pi state | Descriptor: | MAGNESIUM ION, Polyamine-transporting ATPase 13A2, SPERMINE, ... | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Conformational cycle of human polyamine transporter ATP13A2. Nat Commun, 14, 2023
|
|
8HTG
| Crystal structure of Golf in complex with GTP-gamma S and Mg | Descriptor: | 1,2-ETHANEDIOL, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(olf) subunit alpha, ... | Authors: | Kang, H, Choi, H.-J. | Deposit date: | 2022-12-21 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family. Nat Commun, 14, 2023
|
|
8IEO
| Cryo-EM structure of ATP13A2 in the nominal E1P state | Descriptor: | MAGNESIUM ION, Polyamine-transporting ATPase 13A2, SPERMINE, ... | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Conformational cycle of human polyamine transporter ATP13A2. Nat Commun, 14, 2023
|
|
8IEL
| |
8I8X
| Cryo-EM Structure of OmpC3-MlaA-MlaC Complex in MSP2N2 Nanodiscs | Descriptor: | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Intermembrane phospholipid transport system binding protein MlaC, Intermembrane phospholipid transport system lipoprotein MlaA, ... | Authors: | Yeow, J, Luo, M, Chng, S.S. | Deposit date: | 2023-02-05 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Molecular mechanism of phospholipid transport at the bacterial outer membrane interface. Nat Commun, 14, 2023
|
|
8IEK
| |
8HYN
| Bacterial STING from Riemerella anatipestifer | Descriptor: | CD-NTase-associated protein 12, TETRAETHYLENE GLYCOL | Authors: | Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y. | Deposit date: | 2023-01-07 | Release date: | 2024-01-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.089 Å) | Cite: | Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING. Nat Commun, 14, 2023
|
|
8HWJ
| Bacterial STING from Epilithonimonas lactis in complex with 3'3'-c-di-AMP | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CD-NTase-associated protein 12 | Authors: | Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y. | Deposit date: | 2022-12-30 | Release date: | 2024-01-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.553 Å) | Cite: | Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING. Nat Commun, 14, 2023
|
|
8HWI
| Bacterial STING from Larkinella arboricola in complex with 3'3'-c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CD-NTase-associated protein 12 | Authors: | Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y. | Deposit date: | 2022-12-30 | Release date: | 2024-01-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING. Nat Commun, 14, 2023
|
|
8HY8
| Bacterial STING from Epilithonimonas lactis | Descriptor: | CD-NTase-associated protein 12 | Authors: | Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y. | Deposit date: | 2023-01-06 | Release date: | 2024-01-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.568 Å) | Cite: | Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING. Nat Commun, 14, 2023
|
|
8INV
| Crystal structure of UGT74AN3-UDP-BUF | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Glycosyltransferase, URIDINE-5'-DIPHOSPHATE, ... | Authors: | Long, F, Huang, W. | Deposit date: | 2023-03-10 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3 Acs Catalysis, 14, 2024
|
|
8HY9
| Bacterial STING from Riemerella anatipestifer in complex with 3'3'-c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, CD-NTase-associated protein 12 | Authors: | Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y. | Deposit date: | 2023-01-06 | Release date: | 2024-01-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.462 Å) | Cite: | Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING. Nat Commun, 14, 2023
|
|
8INA
| Crystal structure of UGT74AN3-UDP | Descriptor: | GLYCEROL, Glycosyltransferase, URIDINE-5'-DIPHOSPHATE | Authors: | Long, F, Huang, W. | Deposit date: | 2023-03-09 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3 Acs Catalysis, 14, 2024
|
|
8I2N
| The RIPK1 kinase domain in complex with QY7-2B compound | Descriptor: | Receptor-interacting serine/threonine-protein kinase 1, ~{N}-methyl-1-[4-[[[1-methyl-5-(phenylmethyl)pyrazol-3-yl]carbonylamino]methyl]phenyl]benzimidazole-5-carboxamide | Authors: | Gong, X.Y, Li, Y, Meng, H.Y, Pan, L.F. | Deposit date: | 2023-01-14 | Release date: | 2024-01-31 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Structure-based development of potent and selective type-II kinase inhibitors of RIPK1. Acta Pharm Sin B, 14, 2024
|
|
8IQ4
| Cryo-EM structure of Carboprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Lv, X, Gao, K, Nie, J, Zhang, X, Zhang, S, Ren, Y, Li, Q, Huang, J, Liu, L, Zhang, X, Sun, X, Zhang, W, Liu, X. | Deposit date: | 2023-03-15 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity. Nat Commun, 14, 2023
|
|
8I7W
| Cryo-EM structure of GSK256073 bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer | Descriptor: | 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Park, J.H, Ishimoto, N, Park, S.Y. | Deposit date: | 2023-02-02 | Release date: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2. Nat Commun, 14, 2023
|
|
8JIA
| Cryo-EM structure of Mycobacterium tuberculosis ATP bound FtsE(E165Q)X/RipC complex in peptidisc | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... | Authors: | Li, J, Xu, X, Luo, M. | Deposit date: | 2023-05-26 | Release date: | 2023-10-04 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Regulation of the cell division hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis. Nat Commun, 14, 2023
|
|
8JC7
| Cryo-EM structure of Vibrio campbellii alpha-hemolysin | Descriptor: | CALCIUM ION, Hemolysin, POTASSIUM ION | Authors: | Wang, C.H, Yeh, M.K, Ho, M.C, Lin, S.M. | Deposit date: | 2023-05-10 | Release date: | 2023-09-27 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (2.06 Å) | Cite: | Structural basis for calcium-stimulating pore formation of Vibrio alpha-hemolysin. Nat Commun, 14, 2023
|
|
8JDN
| Crystal structure of H405A mLDHD in complex with D-2-hydroxyvaleric acid | Descriptor: | (2R)-2-oxidanylpentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDS
| Crystal structure of mLDHD in complex with Pyruvate | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, PYRUVIC ACID, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.636 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|