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6Z8N
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BU of 6z8n by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small-molecule full agonist SRI-9829
Descriptor: (2~{S})-4-methyl-2-[(1-quinolin-8-ylsulfonylindol-3-yl)carbonylamino]pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1)
Authors:Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
Deposit date:2020-06-02
Release date:2021-02-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
5T1A
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BU of 5t1a by Molmil
Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2~{R})-1-(4-chloranyl-2-fluoranyl-phenyl)-2-cyclohexyl-3-ethanoyl-4-oxidanyl-2~{H}-pyrrol-5-one, (3S)-1-{(1S,2R,4R)-4-[methyl(propan-2-yl)amino]-2-propylcyclohexyl}-3-{[6-(trifluoromethyl)quinazolin-4-yl]amino}pyrrolidin-2-one, ...
Authors:Zheng, Y, Qin, L, Ortiz Zacarias, N.V, de Vries, H, Han, G.W, Gustavsson, M, Dabros, M, Zhao, C, Cherney, R.J, Carter, P, Stamos, D, Abagyan, R, Cherezov, V, Stevens, R.C, IJzerman, A.P, Heitman, L.H, Tebben, A, Kufareva, I, Handel, T.M.
Deposit date:2016-08-18
Release date:2016-12-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.806 Å)
Cite:Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.
Nature, 540, 2016
5EN0
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BU of 5en0 by Molmil
Crystal Structure of T94I rhodopsin mutant
Descriptor: ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-3, PALMITIC ACID, ...
Authors:Singhal, A, Guo, Y, Matkovic, M, Schertler, G, Deupi, X, Yan, E, Standfuss, J.
Deposit date:2015-11-08
Release date:2016-08-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural role of the T94I rhodopsin mutation in congenital stationary night blindness.
Embo Rep., 17, 2016
7YKD
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BU of 7ykd by Molmil
Cryo-EM structure of the human chemerin receptor 1 complex with the C-terminal nonapeptide of chemerin
Descriptor: CHOLESTEROL, Chemerin-like receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Chen, G, Liao, Q, Ye, R.D, Wang, J.
Deposit date:2022-07-22
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin.
Proc.Natl.Acad.Sci.USA, 120, 2023
5ZKP
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BU of 5zkp by Molmil
Crystal structure of the human platelet-activating factor receptor in complex with SR 27417
Descriptor: FLAVIN MONONUCLEOTIDE, N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine, Platelet-activating factor receptor,Flavodoxin,Platelet-activating factor receptor
Authors:Cao, C, Zhao, Q, Zhang, X.C, Wu, B.
Deposit date:2018-03-25
Release date:2018-06-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
8ZRK
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BU of 8zrk by Molmil
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist GSK-1292263
Descriptor: 5-[4-[[6-(4-methylsulfonylphenyl)pyridin-3-yl]oxymethyl]piperidin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Wong, T.S, Xiong, T.T, Zeng, Z.C, Gan, S.Y, Qiu, C, Du, Y.
Deposit date:2024-06-04
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Cryo-EM structure of GPR119-Gs complex
To be published
8DZQ
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BU of 8dzq by Molmil
momSalB bound Kappa Opioid Receptor in complex with GoA
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ...
Authors:Fay, J.F, Che, T.
Deposit date:2022-08-08
Release date:2023-05-03
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Ligand and G-protein selectivity in the kappa-opioid receptor.
Nature, 617, 2023
8XBH
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BU of 8xbh by Molmil
Human GPR34 -Gi complex bound to M1
Descriptor: (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Kawahara, R, Shihoya, W, Nureki, O.
Deposit date:2023-12-06
Release date:2023-12-27
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Structural basis for lysophosphatidylserine recognition by GPR34.
Nat Commun, 15, 2024
7TD0
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BU of 7td0 by Molmil
Lysophosphatidic acid receptor 1-Gi complex bound to LPA
Descriptor: (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y.
Deposit date:2021-12-30
Release date:2022-02-09
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022
7VIF
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BU of 7vif by Molmil
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P
Descriptor: (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B.
Deposit date:2021-09-26
Release date:2022-09-28
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Structural insights into sphingosine-1-phosphate receptor activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
8KH5
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BU of 8kh5 by Molmil
Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Nie, Y, Qiu, Z, Zheng, S, Chen, S.
Deposit date:2023-08-21
Release date:2023-10-18
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
Nat Commun, 14, 2023
8K4N
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BU of 8k4n by Molmil
Structure of GPR34-Gi complex
Descriptor: (2R)-2-azanyl-3-[oxidanyl-[(2R)-2-oxidanyl-3-tetradec-9-enoyloxy-propoxy]phosphoryl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wong, T.S, Zeng, Z.C, Xiong, T.T, Gan, S.Y, He, G.D, Du, Y.
Deposit date:2023-07-20
Release date:2023-10-25
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Cryo-EM structure of GPR34-Gi complex
To Be Published
4ZJC
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BU of 4zjc by Molmil
Structures of the human OX1 orexin receptor bound to selective and dual antagonists
Descriptor: OLEIC ACID, [5-(2-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]{(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-1-yl}methanone, human OX1R fusion protein to P.abysii glycogen synthase
Authors:Yin, J, Brautigam, C.A, Shao, Z, Clark, L, Harrell, C.M, Gotter, A.L, Coleman, P.J, Renger, J.J, Rosenbaum, D.M.
Deposit date:2015-04-29
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.832 Å)
Cite:Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
7VUY
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BU of 7vuy by Molmil
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12. state1
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Li, Y, Yang, F.
Deposit date:2021-11-04
Release date:2021-12-01
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
3NY8
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BU of 3ny8 by Molmil
Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]butan-2-ol, Beta-2 adrenergic receptor, ...
Authors:Wacker, D, Fenalti, G, Brown, M.A, Katritch, V, Abagyan, R, Cherezov, V, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-07-14
Release date:2010-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
J.Am.Chem.Soc., 132, 2010
3NY9
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BU of 3ny9 by Molmil
Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Beta-2 adrenergic receptor, Lysozyme, ...
Authors:Fenalti, G, Wacker, D, Brown, M.A, Katritch, V, Abagyan, R, Cherezov, V, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-07-14
Release date:2010-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
J.Am.Chem.Soc., 132, 2010
8JLQ
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BU of 8jlq by Molmil
Fenoldopam-bound hTAAR1-Gs protein complex
Descriptor: (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
Deposit date:2023-06-02
Release date:2023-11-15
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JGB
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BU of 8jgb by Molmil
CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2
Descriptor: Conorfamide-Tx2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y.
Deposit date:2023-05-20
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.
Nat Commun, 14, 2023
8GUR
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BU of 8gur by Molmil
Cryo-EM structure of CP-CB2-G protein complex
Descriptor: 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H.
Deposit date:2022-09-13
Release date:2023-05-10
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Structural basis of selective cannabinoid CB 2 receptor activation.
Nat Commun, 14, 2023
8DPF
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BU of 8dpf by Molmil
Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to lorcaserin
Descriptor: (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ...
Authors:Gumpper, R.H, Fay, J.F, Roth, B.L.
Deposit date:2022-07-15
Release date:2022-08-24
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors.
Cell Rep, 40, 2022
8XJM
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BU of 8xjm by Molmil
Latanoprost acid bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Descriptor: Antibody fragment scFv16, Engineered miniGq, Fusion tag,Prostaglandin F2-alpha receptor,LgBiT, ...
Authors:Zhang, X, Li, X, Liu, G, Gong, W.
Deposit date:2023-12-21
Release date:2024-02-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
8IHB
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BU of 8ihb by Molmil
Cryo-EM structure of HCA2-Gi complex with GSK256073
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y.
Deposit date:2023-02-22
Release date:2023-09-13
Last modified:2023-12-06
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
Nat Commun, 14, 2023
8FYE
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BU of 8fye by Molmil
4-F, 5-MeO-PyrT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Descriptor: 4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D.
Deposit date:2023-01-26
Release date:2024-05-15
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Nature, 630, 2024
7XAT
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BU of 7xat by Molmil
Structure of somatostatin receptor 2 bound with SST14.
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L.
Deposit date:2022-03-19
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues.
Cell Discov, 8, 2022
2Y03
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BU of 2y03 by Molmil
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST ISOPRENALINE
Descriptor: BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A, Moukhametzianov, R, Baker, J.G, Nehme, R, Edwards, P.C, Leslie, A.G.W, Schertler, G.F.X, Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011

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