5M37
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![BU of 5m37 by Molmil](/molmil-images/mine/5m37) | The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | Descriptor: | (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... | Authors: | Bier, D, Ottmann, C. | Deposit date: | 2016-10-14 | Release date: | 2017-11-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
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1AXI
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![BU of 1axi by Molmil](/molmil-images/mine/1axi) | STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE | Descriptor: | GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION | Authors: | Atwell, S, Ultsch, M, De Vos, A.M, Wells, J.A. | Deposit date: | 1997-10-15 | Release date: | 1998-01-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural plasticity in a remodeled protein-protein interface. Science, 278, 1997
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5M36
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![BU of 5m36 by Molmil](/molmil-images/mine/5m36) | The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | Descriptor: | (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... | Authors: | Bier, D, Ottmann, C. | Deposit date: | 2016-10-14 | Release date: | 2017-11-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
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5M35
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![BU of 5m35 by Molmil](/molmil-images/mine/5m35) | |
8TJF
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![BU of 8tjf by Molmil](/molmil-images/mine/8tjf) | monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface | Descriptor: | Fab Lambda light chain, IgG1 Fab heavy chain | Authors: | Oganesyan, V.Y, van Dyk, N, Mazor, Y, Chiang, C. | Deposit date: | 2023-07-21 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C H 1-C lambda interface. Mabs, 15, 2023
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8TI4
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![BU of 8ti4 by Molmil](/molmil-images/mine/8ti4) | monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface | Descriptor: | GLYCEROL, IgG1 Fab heavy chain, mutated to promote correct pairing, ... | Authors: | Oganesyan, V.Y, van Dyk, N, Mazor, Y. | Deposit date: | 2023-07-19 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C H 1-C lambda interface. Mabs, 15, 2023
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5GN8
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![BU of 5gn8 by Molmil](/molmil-images/mine/5gn8) | Structure of a 48-mer protein nanocage fabricated from its 24-mer analogue by subunit interface redesign | Descriptor: | CALCIUM ION, Ferritin heavy chain | Authors: | Zhang, S, Zang, J, Zhao, G, Mikami, B. | Deposit date: | 2016-07-19 | Release date: | 2016-12-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.805 Å) | Cite: | "Silent" Amino Acid Residues at Key Subunit Interfaces Regulate the Geometry of Protein Nanocages ACS Nano, 10, 2016
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1YM5
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![BU of 1ym5 by Molmil](/molmil-images/mine/1ym5) | Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily. | Descriptor: | Hypothetical 32.6 kDa protein in DAP2-SLT2 intergenic region | Authors: | Liger, D, Quevillon-Cheruel, S, Sorel, I, Bremang, M, Blondeau, K, Aboulfath, I, Janin, J, Van Tilbeurgh, H, Leulliot, N, Paris-Sud Yeast Structural Genomics (YSG) | Deposit date: | 2005-01-20 | Release date: | 2005-08-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily Proteins, 60, 2005
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1B48
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![BU of 1b48 by Molmil](/molmil-images/mine/1b48) | |
5DWW
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![BU of 5dww by Molmil](/molmil-images/mine/5dww) | |
5DWX
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![BU of 5dwx by Molmil](/molmil-images/mine/5dwx) | |
6GJU
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![BU of 6gju by Molmil](/molmil-images/mine/6gju) | human NBD1 of CFTR in complex with nanobodies T2a and T4 | Descriptor: | Cystic fibrosis transmembrane conductance regulator, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. | Deposit date: | 2018-05-17 | Release date: | 2019-06-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
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6GJS
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![BU of 6gjs by Molmil](/molmil-images/mine/6gjs) | Human NBD1 of CFTR in complex with nanobodies D12 and T4 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ... | Authors: | Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. | Deposit date: | 2018-05-16 | Release date: | 2019-06-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
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6GK4
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![BU of 6gk4 by Molmil](/molmil-images/mine/6gk4) | Human NBD1 of CFTR in complex with nanobodies D12 and T8 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, GLYCEROL, ... | Authors: | Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. | Deposit date: | 2018-05-18 | Release date: | 2019-06-19 | Last modified: | 2019-08-21 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
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6GC2
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![BU of 6gc2 by Molmil](/molmil-images/mine/6gc2) | AbLIFT: Antibody stability and affinity optimization by computational design of the variable light-heavy chain interface | Descriptor: | Heavy chain, Light Chain | Authors: | Warszawski, S, Katz, A, Khmelnitsky, L, Ben Nissan, G, Javitt, G, Dym, O, Unger, T, Knop, O, Diskin, R, Albeck, S, Fass, D, Sharon, M, Fleishman, S.J. | Deposit date: | 2018-04-17 | Release date: | 2019-05-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces. Plos Comput.Biol., 15, 2019
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5VHT
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![BU of 5vht by Molmil](/molmil-images/mine/5vht) | E. coli chorismate mutase with orthogonal interface containing p-benzoyl phenylalanine | Descriptor: | Chorismate Mutase | Authors: | Koh, M, Nasertorabi, F, Han, G.W, Stevens, R.C, Shultz, P.G. | Deposit date: | 2017-04-13 | Release date: | 2017-05-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid. J. Am. Chem. Soc., 139, 2017
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6Q5Z
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![BU of 6q5z by Molmil](/molmil-images/mine/6q5z) | H-Vc7.2, H-superfamily conotoxin | Descriptor: | Conotoxin Vc7.2 | Authors: | Nielsen, L.D, Foged, M.M, Teilum, K, Ellgaard, L. | Deposit date: | 2018-12-10 | Release date: | 2019-04-17 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework. J.Biol.Chem., 294, 2019
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6GJQ
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![BU of 6gjq by Molmil](/molmil-images/mine/6gjq) | human NBD1 of CFTR in complex with nanobody T27 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, Nanobody T27 | Authors: | Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. | Deposit date: | 2018-05-16 | Release date: | 2019-06-19 | Last modified: | 2019-08-21 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
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2VRN
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![BU of 2vrn by Molmil](/molmil-images/mine/2vrn) | The structure of the stress response protein DR1199 from Deinococcus radiodurans: a member of the DJ-1 superfamily | Descriptor: | MAGNESIUM ION, PROTEASE I | Authors: | Fioravanti, E, Dura, M.A, Lascoux, D, Micossi, E, McSweeney, S. | Deposit date: | 2008-04-09 | Release date: | 2008-10-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure of the stress response protein DR1199 from Deinococcus radiodurans: a member of the DJ-1 superfamily. Biochemistry, 47, 2008
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6GKD
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![BU of 6gkd by Molmil](/molmil-images/mine/6gkd) | human NBD1 of CFTR in complex with nanobodies D12 and G3a | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, GLYCEROL, ... | Authors: | Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. | Deposit date: | 2018-05-18 | Release date: | 2019-06-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
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1VJN
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6LKG
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![BU of 6lkg by Molmil](/molmil-images/mine/6lkg) | two-component system protein mediate signal transduction | Descriptor: | 6-O-phosphono-alpha-D-glucopyranose, ABC transporter, solute-binding protein, ... | Authors: | Wang, M, Tao, Y. | Deposit date: | 2019-12-19 | Release date: | 2020-12-02 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.948 Å) | Cite: | Interface switch mediates signal transmission in a two-component system. Proc.Natl.Acad.Sci.USA, 117, 2020
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6LKK
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![BU of 6lkk by Molmil](/molmil-images/mine/6lkk) | Two-component system protein mediate signal transduction | Descriptor: | 6-O-phosphono-alpha-D-glucopyranose, ABC transporter, solute-binding protein | Authors: | Wang, M, Tao, Y. | Deposit date: | 2019-12-19 | Release date: | 2020-12-02 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.502 Å) | Cite: | Interface switch mediates signal transmission in a two-component system. Proc.Natl.Acad.Sci.USA, 117, 2020
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6LKL
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![BU of 6lkl by Molmil](/molmil-images/mine/6lkl) | Two-component system protein mediate signal transduction | Descriptor: | ABC transporter, solute-binding protein, MALONIC ACID | Authors: | Wang, M, Tao, Y. | Deposit date: | 2019-12-19 | Release date: | 2020-12-02 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.213 Å) | Cite: | Interface switch mediates signal transmission in a two-component system. Proc.Natl.Acad.Sci.USA, 117, 2020
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6LKI
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![BU of 6lki by Molmil](/molmil-images/mine/6lki) | Two-component system protein mediate signal transduction | Descriptor: | ABC transporter, solute-binding protein, MALONIC ACID, ... | Authors: | Wang, M, Tao, Y. | Deposit date: | 2019-12-19 | Release date: | 2020-12-02 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.781 Å) | Cite: | Interface switch mediates signal transmission in a two-component system. Proc.Natl.Acad.Sci.USA, 117, 2020
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