4HND
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![BU of 4hnd by Molmil](/molmil-images/mine/4hnd) | Crystal structure of the catalytic domain of Selenomethionine substituted human PI4KIIalpha in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase type 2-alpha | Authors: | Zhou, Q, Zhai, Y, Zhang, K, Chen, C, Sun, F. | Deposit date: | 2012-10-19 | Release date: | 2014-04-09 | Last modified: | 2016-12-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha. Nat Commun, 5, 2014
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6Z2X
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![BU of 6z2x by Molmil](/molmil-images/mine/6z2x) | Mec1-Ddc2 (F2244L mutant) in complex with Mg AMP-PNP (State II) | Descriptor: | DNA damage checkpoint protein LCD1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Yates, L.A, Zhang, X. | Deposit date: | 2020-05-18 | Release date: | 2020-11-11 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of auto-inhibition and activation of Mec1 ATR checkpoint kinase. Nat.Struct.Mol.Biol., 28, 2021
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6ZWM
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![BU of 6zwm by Molmil](/molmil-images/mine/6zwm) | cryo-EM structure of human mTOR complex 2, overall refinement | Descriptor: | ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. | Deposit date: | 2020-07-28 | Release date: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
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7UXC
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![BU of 7uxc by Molmil](/molmil-images/mine/7uxc) | |
7UXH
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![BU of 7uxh by Molmil](/molmil-images/mine/7uxh) | cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Cui, Z, Hurley, J. | Deposit date: | 2022-05-05 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
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4JSN
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![BU of 4jsn by Molmil](/molmil-images/mine/4jsn) | structure of mTORdeltaN-mLST8 complex | Descriptor: | Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 | Authors: | Pavletich, N.P. | Deposit date: | 2013-03-22 | Release date: | 2013-05-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
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5EUQ
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![BU of 5euq by Molmil](/molmil-images/mine/5euq) | |
3P2B
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![BU of 3p2b by Molmil](/molmil-images/mine/3p2b) | Crystal Structure of PI3K gamma with 3-(2-morpholino-6-(pyridin-3-ylamino)pyrimidin-4-yl)phenol | Descriptor: | 3-[2-morpholin-4-yl-6-(pyridin-3-ylamino)pyrimidin-4-yl]phenol, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Authors: | Knapp, M.S, Elling, R.A, Ornelas, E. | Deposit date: | 2010-10-01 | Release date: | 2011-08-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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7K11
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![BU of 7k11 by Molmil](/molmil-images/mine/7k11) | |
6BCX
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![BU of 6bcx by Molmil](/molmil-images/mine/6bcx) | mTORC1 structure refined to 3.0 angstroms | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ... | Authors: | Pavletich, N.P, Yang, H. | Deposit date: | 2017-10-20 | Release date: | 2017-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
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7OTV
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![BU of 7otv by Molmil](/molmil-images/mine/7otv) | DNA-PKcs in complex with wortmannin | Descriptor: | (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE, DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs | Authors: | Liang, S, Thomas, S.E, Blundell, T.L. | Deposit date: | 2021-06-10 | Release date: | 2022-01-12 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. Nature, 601, 2022
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6ZFP
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![BU of 6zfp by Molmil](/molmil-images/mine/6zfp) | Cryo-EM structure of DNA-PKcs (State 2) | Descriptor: | DNA-dependent protein kinase catalytic subunit,DNA-PKcs,DNA-PKcs | Authors: | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | Deposit date: | 2020-06-17 | Release date: | 2020-10-21 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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7BI2
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![BU of 7bi2 by Molmil](/molmil-images/mine/7bi2) | PI3KC2aDeltaN and DeltaC-C2 | Descriptor: | 1,2-ETHANEDIOL, 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one, IODIDE ION, ... | Authors: | Lo, W.T, Roske, Y, Daumke, O, Haucke, V. | Deposit date: | 2021-01-12 | Release date: | 2022-03-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structural basis of phosphatidylinositol 3-kinase C2 alpha function. Nat.Struct.Mol.Biol., 29, 2022
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4KZC
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![BU of 4kzc by Molmil](/molmil-images/mine/4kzc) | Structure of PI3K gamma with Imidazopyridine inhibitors | Descriptor: | N-{6-[6-amino-5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-a]pyridin-2-yl}acetamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | Authors: | Knapp, M.S, Elling, E.A. | Deposit date: | 2013-05-29 | Release date: | 2013-07-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K. Bioorg.Med.Chem.Lett., 23, 2013
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7PW4
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![BU of 7pw4 by Molmil](/molmil-images/mine/7pw4) | Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor | Descriptor: | 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Langer, L.M, Conti, E. | Deposit date: | 2021-10-06 | Release date: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. Elife, 10, 2021
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5FBR
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![BU of 5fbr by Molmil](/molmil-images/mine/5fbr) | PI4KB in complex with Rab11 and the MI359 Inhibitor | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... | Authors: | Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. | Deposit date: | 2015-12-14 | Release date: | 2016-12-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.28 Å) | Cite: | PI4KB in complex with Rab11 and the MI359 Inhibitor To Be Published
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7TZO
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![BU of 7tzo by Molmil](/molmil-images/mine/7tzo) | The apo structure of human mTORC2 complex | Descriptor: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | Authors: | Yu, Z, Chen, J, Pearce, D. | Deposit date: | 2022-02-16 | Release date: | 2023-01-11 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. J.Biol.Chem., 298, 2022
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5FBV
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![BU of 5fbv by Molmil](/molmil-images/mine/5fbv) | PI4KB in complex with Rab11 and the MI364 Inhibitor | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... | Authors: | Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. | Deposit date: | 2015-12-14 | Release date: | 2016-12-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.285 Å) | Cite: | PI4KB in complex with Rab11 and the MI364 Inhibitor To Be Published
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7SU3
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![BU of 7su3 by Molmil](/molmil-images/mine/7su3) | CryoEM structure of DNA-PK complex VII | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), ... | Authors: | Chen, X, Liu, L, Gellert, M, Yang, W. | Deposit date: | 2021-11-16 | Release date: | 2022-01-12 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol.Cell, 82, 2022
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3HIZ
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![BU of 3hiz by Molmil](/molmil-images/mine/3hiz) | Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha | Descriptor: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Amzel, L.M, Vogelstein, B, Gabelli, S.B, Mandelker, D. | Deposit date: | 2009-05-20 | Release date: | 2009-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane. Proc.Natl.Acad.Sci.USA, 106, 2009
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2Y3A
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![BU of 2y3a by Molmil](/molmil-images/mine/2y3a) | Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 | Descriptor: | 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM | Authors: | Zhang, X, Vadas, O, Perisic, O, Williams, R.L. | Deposit date: | 2010-12-20 | Release date: | 2011-03-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism. Mol.Cell, 41, 2011
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8OXM
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![BU of 8oxm by Molmil](/molmil-images/mine/8oxm) | ATM(Q2971A) activated by oxidative stress in complex with Mg AMP-PNP and p53 peptide | Descriptor: | Cellular tumor antigen p53, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Howes, A.C, Perisic, O, Williams, R.L. | Deposit date: | 2023-05-02 | Release date: | 2023-09-27 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress. Sci Adv, 9, 2023
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7K10
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![BU of 7k10 by Molmil](/molmil-images/mine/7k10) | |
5SW8
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![BU of 5sw8 by Molmil](/molmil-images/mine/5sw8) | Crystal structure of PI3Kalpha in complex with fragments 7 and 11 | Descriptor: | 2-CHLOROBENZENESULFONAMIDE, 2H-indazol-5-amine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M. | Deposit date: | 2016-08-08 | Release date: | 2017-02-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design. Bioorg. Med. Chem., 25, 2017
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4JSP
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![BU of 4jsp by Molmil](/molmil-images/mine/4jsp) | structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase mTOR, ... | Authors: | Pavletich, N.P, Yang, H. | Deposit date: | 2013-03-22 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
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