3SD5
Crystal Structure of PI3K gamma with 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine
Summary for 3SD5
Entry DOI | 10.2210/pdb3sd5/pdb |
Related | 3P2B |
Descriptor | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 5-[2,6-di(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine (3 entities in total) |
Functional Keywords | lipid kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P48736 |
Total number of polymer chains | 1 |
Total formula weight | 111166.56 |
Authors | Knapp, M.S.,Elling, R.A. (deposition date: 2011-06-08, release date: 2012-01-04, Last modification date: 2023-09-13) |
Primary citation | Maira, S.M.,Pecchi, S.,Huang, A.,Burger, M.,Knapp, M.,Sterker, D.,Schnell, C.,Guthy, D.,Nagel, T.,Wiesmann, M.,Brachmann, S.,Fritsch, C.,Dorsch, M.,Chene, P.,Shoemaker, K.,De Pover, A.,Menezes, D.,Martiny-Baron, G.,Fabbro, D.,Wilson, C.J.,Schlegel, R.,Hofmann, F.,Garcia-Echeverria, C.,Sellers, W.R.,Voliva, C.F. Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor. Mol.Cancer Ther., 11:317-328, 2012 Cited by PubMed: 22188813DOI: 10.1158/1535-7163.MCT-11-0474 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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