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1NRV
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BU of 1nrv by Molmil
Crystal structure of the SH2 domain of Grb10
Descriptor: Growth factor receptor-bound protein 10
Authors:Stein, E.G, Hubbard, S.R.
Deposit date:2003-01-25
Release date:2003-04-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.
J.Biol.Chem., 278, 2003
1O4N
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BU of 1o4n by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH OXALIC ACID.
Descriptor: OXALIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1NZV
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BU of 1nzv by Molmil
Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYIpYVPA
Descriptor: CHLORIDE ION, Doubly phosphorylated peptide PQpYIpYVPA, TETRAETHYLENE GLYCOL, ...
Authors:Lubman, O.Y, Waksman, G.
Deposit date:2003-02-19
Release date:2003-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Thermodynamic Basis for the Interaction of the Src SH2 domain with the Activated form of the PDGF beta-receptor
J.Mol.Biol., 328, 2003
1O4D
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BU of 1o4d by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78262.
Descriptor: 2-FORMYLPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4J
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BU of 1o4j by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH ISO24.
Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [(4-ETHYLPHENYL)AMINO]CARBONYLPHOSPHONIC ACID
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O43
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BU of 1o43 by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82129.
Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [4-((1Z)-2-(ACETYLAMINO)-3-{[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]AMINO}-3-OXOPROP-1-ENYL)-2-FORMYLPHENYL]ACET IC ACID
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O49
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BU of 1o49 by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85493.
Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, {4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENOXY}-ACETIC ACID
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4G
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BU of 1o4g by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH DPI59.
Descriptor: HYDROXY(1-NAPHTHYL)METHYLPHOSPHONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4M
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BU of 1o4m by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH MALONICACID.
Descriptor: MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O45
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BU of 1o45 by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU84687.
Descriptor: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3-FORMYL-O-PHOSPHONOTYROSINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4F
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BU of 1o4f by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79073.
Descriptor: 1,2,3,4-TETRAHYDROQUINOLIN-8-YL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4K
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BU of 1o4k by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PASBN.
Descriptor: BENZYL 2-FORMYLPHENYL HYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4A
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BU of 1o4a by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82197.
Descriptor: 4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-FORMYL-BENZOIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
7EMN
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BU of 7emn by Molmil
The atomic structure of SHP2 E76A mutant
Descriptor: Tyrosine-protein phosphatase non-receptor type 11
Authors:Luo, F, Xie, J.J, Zhu, J.D, Liu, C.
Deposit date:2021-04-14
Release date:2021-05-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:A novel partially open state of SHP2 points to a "multiple gear" regulation mechanism.
J.Biol.Chem., 296, 2021
2Y3A
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BU of 2y3a by Molmil
Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941
Descriptor: 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
Authors:Zhang, X, Vadas, O, Perisic, O, Williams, R.L.
Deposit date:2010-12-20
Release date:2011-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism.
Mol.Cell, 41, 2011
5IBM
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BU of 5ibm by Molmil
Structure of S502P, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2
Descriptor: Tyrosine-protein phosphatase non-receptor type 11
Authors:Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R.
Deposit date:2016-02-22
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.
Biochemistry, 55, 2016
5MO4
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BU of 5mo4 by Molmil
ABL1 kinase (T334I_D382N) in complex with asciminib and nilotinib
Descriptor: Nilotinib, Tyrosine-protein kinase ABL1, asciminib
Authors:Cowan-Jacob, S.W.
Deposit date:2016-12-13
Release date:2017-04-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Nature, 543, 2017
4XI2
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BU of 4xi2 by Molmil
Crystal Structure of an auto-inhibited form of Bruton's Tryrosine Kinase
Descriptor: GOLD ION, Tyrosine-protein kinase BTK
Authors:Vogan, E.M, Harrison, S.C.
Deposit date:2015-01-06
Release date:2015-02-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.
Elife, 4, 2015
4XEY
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BU of 4xey by Molmil
Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase
Descriptor: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Tyrosine-protein kinase ABL1
Authors:Lorenz, S, Deng, P, Kuriyan, J.
Deposit date:2014-12-25
Release date:2015-04-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.891 Å)
Cite:Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.
Biochem.J., 468, 2015
6TLC
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BU of 6tlc by Molmil
Unphosphorylated human STAT3 in complex with MS3-6 monobody
Descriptor: Monobody, Signal transducer and activator of transcription 3
Authors:La Sala, G, Lau, K, Reynaud, A, Pojer, F, Hantschel, O.
Deposit date:2019-12-02
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains.
Nat Commun, 11, 2020
6UX2
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BU of 6ux2 by Molmil
Crystal structure of ZIKV RdRp in complex with STAT2
Descriptor: Nonstructural Protein 5, SULFATE ION, Signal transducer and activator of transcription 2, ...
Authors:Wang, B, Song, J.
Deposit date:2019-11-06
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structural basis for STAT2 suppression by flavivirus NS5.
Nat.Struct.Mol.Biol., 27, 2020
5M6U
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BU of 5m6u by Molmil
HUMAN PI3KDELTA IN COMPLEX WITH LASW1579
Descriptor: 4-azanyl-6-[[(1~{S})-1-(4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Authors:Segarra, V, Hernandez, B, Lozoya, E, Blaesse, M, Hoeppner, S, Jestel, A.
Deposit date:2016-10-26
Release date:2017-02-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Discovery of a Potent, Selective, and Orally Available PI3K delta Inhibitor for the Treatment of Inflammatory Diseases.
ACS Med Chem Lett, 8, 2017
6PBC
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BU of 6pbc by Molmil
Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION
Authors:Hajicek, N, Sondek, J.
Deposit date:2019-06-13
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations.
Elife, 8, 2019
4U5W
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BU of 4u5w by Molmil
Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Protein Nef, ...
Authors:Alvarado, J.J, Yeh, J.I, Smithgall, T.E.
Deposit date:2014-07-25
Release date:2014-08-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment.
J.Biol.Chem., 289, 2014
4WAF
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BU of 4waf by Molmil
Crystal Structure of a novel tetrahydropyrazolo[1,5-a]pyrazine in an engineered PI3K alpha
Descriptor: N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Knapp, M.S, Elling, R.A.
Deposit date:2014-08-29
Release date:2014-12-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR Inhibitors.
Acs Med.Chem.Lett., 6, 2015

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