5CJO
 
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6AZ2
 | | Crystal structure of Asf1-Fab 12E complex | | Descriptor: | Fab Heavy Chain, Fab Light Chain, Histone chaperone ASF1 | | Authors: | Bailey, L.J, Kossiakoff, A.A. | | Deposit date: | 2017-09-09 | | Release date: | 2018-01-10 | | Last modified: | 2018-02-14 | | Method: | X-RAY DIFFRACTION (2.477 Å) | | Cite: | Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 430, 2018
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6AYZ
 | | Crystal structure of Asf1-Fab 12E complex | | Descriptor: | Fab Heavy Chain, Fab Light Chain, Histone chaperone ASF1 | | Authors: | Bailey, L.J, Kossiakoff, A.A. | | Deposit date: | 2017-09-08 | | Release date: | 2018-01-17 | | Last modified: | 2020-01-01 | | Method: | X-RAY DIFFRACTION (2.096 Å) | | Cite: | Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 430, 2018
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8FIS
 | | Structure of Bispecific CAP256V2LS-J3 Fab in complex with BG505 DS-SOSIP.664 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | | Authors: | Gorman, J, Kwong, P.D. | | Deposit date: | 2022-12-16 | | Release date: | 2023-02-01 | | Last modified: | 2023-02-15 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency.
Mabs, 15, 2023
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6WGK
 | | Fab portion of dupilumab with Crystal Kappa design and intrachain disulfide | | Descriptor: | Dupilumab Fab heavy chain, Dupilumab Fab light chain | | Authors: | Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J. | | Deposit date: | 2020-04-05 | | Release date: | 2020-09-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
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6WGL
 | | Dupilumab fab with Crystal Kappa design complexed with human IL-4 receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dupilumab Fab heavy chain, ... | | Authors: | Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J. | | Deposit date: | 2020-04-05 | | Release date: | 2020-09-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.82 Å) | | Cite: | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
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6WGB
 | | Crystal structure of the fab portion of dupilumab | | Descriptor: | Dupilumab Fab heavy chain, Dupilumab Fab light chain | | Authors: | Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J. | | Deposit date: | 2020-04-05 | | Release date: | 2020-09-16 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
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6WIO
 | | Fab antigen complex | | Descriptor: | Fab Heavy chain, Fab Light chain, Interleukin-17A | | Authors: | Antonysamy, S. | | Deposit date: | 2020-04-10 | | Release date: | 2020-09-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
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6WIR
 | | Fab antigen complex | | Descriptor: | Fab heavy chain, Fab light chain, Interleukin-17A | | Authors: | Antonysamy, S. | | Deposit date: | 2020-04-10 | | Release date: | 2020-09-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.96 Å) | | Cite: | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
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6WG8
 | | Fab portion of dupilumab with Crystal Kappa design | | Descriptor: | Dupilumab Fab heavy chain, Dupilumab Fab light chain, GLYCEROL | | Authors: | Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J. | | Deposit date: | 2020-04-05 | | Release date: | 2020-09-16 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.36 Å) | | Cite: | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
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6WGJ
 | | Fab portion of dupilumab with Crystal Kappa design and no interchain disulfide | | Descriptor: | Dupilumab Fab heavy chain, Dupilumab Fab light chain | | Authors: | Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J. | | Deposit date: | 2020-04-05 | | Release date: | 2020-09-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
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7R8U
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7L57
 | | Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-15 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Rapp, M, Shapiro, L. | | Deposit date: | 2020-12-21 | | Release date: | 2021-04-14 | | Last modified: | 2021-04-21 | | Method: | ELECTRON MICROSCOPY (5.87 Å) | | Cite: | Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class.
Cell Rep, 35, 2021
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7L56
 | | Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-43 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 2-43 variable domain heavy chain, ... | | Authors: | Rapp, M, Shapiro, L. | | Deposit date: | 2020-12-21 | | Release date: | 2021-04-14 | | Last modified: | 2023-04-05 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class.
Cell Rep, 35, 2021
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7L58
 | | Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab H4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab H4 variable domain heavy chain, ... | | Authors: | Rapp, M, Shapiro, L. | | Deposit date: | 2020-12-21 | | Release date: | 2021-04-14 | | Last modified: | 2021-04-21 | | Method: | ELECTRON MICROSCOPY (5.07 Å) | | Cite: | Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class.
Cell Rep, 35, 2021
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3U7Y
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4HHA
 | | Anti-Human Cytomegalovirus (HCMV) Fab KE5 with epitope peptide AD-2S1 | | Descriptor: | Antibody KE5, CHLORIDE ION, Fab KE5, ... | | Authors: | Bryson, S, Risnes, L, Damgupta, S, Thomson, C.A, Pfoh, R, Schrader, J.W, Pai, E.F. | | Deposit date: | 2012-10-09 | | Release date: | 2013-10-23 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation.
J. Immunol., 196, 2016
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4HIE
 | | Anti-Streptococcus pneumoniae 23F Fab 023.102 | | Descriptor: | Antibody 023.102, Fab 023.102 | | Authors: | Bryson, S, Risnes, L, Damgupta, S, Thomson, C.A, Schrader, J.W, Pai, E.F. | | Deposit date: | 2012-10-11 | | Release date: | 2013-08-28 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation.
J. Immunol., 196, 2016
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4HIH
 | | Anti-Streptococcus pneumoniae 23F Fab 023.102 with bound rhamnose. | | Descriptor: | Antibody 023.102, Fab 023.102, alpha-L-rhamnopyranose | | Authors: | Bryson, S, Risnes, L, Damgupta, S, Thomson, C.A, Schrader, J.W, Pai, E.F. | | Deposit date: | 2012-10-11 | | Release date: | 2013-08-28 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation.
J. Immunol., 196, 2016
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7V05
 | | Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab | | Descriptor: | 850 Fab Heavy Chain, 850 Fab Light Chain, Circumsporozoite protein | | Authors: | Kucharska, I, Prieto, K, Rubinstein, J.L, Julien, J.P. | | Deposit date: | 2022-05-09 | | Release date: | 2022-11-23 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire.
Plos Pathog., 18, 2022
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7UYM
 | | 850 Fab in complex with NANPNANPNANP peptide | | Descriptor: | 850 Fab Heavy Chain, 850 Fab Light Chain, Circumsporozoite protein, ... | | Authors: | Kucharska, I, Prieto, K, Julien, J.P. | | Deposit date: | 2022-05-06 | | Release date: | 2022-11-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire.
Plos Pathog., 18, 2022
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7UYL
 | | 850 Fab | | Descriptor: | 850 Fab Heavy Chain, 850 Fab Light Chain, GLYCEROL, ... | | Authors: | Kucharska, I, Prieto, K, Julien, J.P. | | Deposit date: | 2022-05-06 | | Release date: | 2022-11-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire.
Plos Pathog., 18, 2022
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6TKB
 | | ChiLob 7/4 H2 HC-C224S F(ab')2 | | Descriptor: | Chilob 7/4 H2 heavy chain C224S, Chilob 7/4 H2 kappa chain | | Authors: | Orr, C.M, Fisher, H, Tews, I. | | Deposit date: | 2019-11-28 | | Release date: | 2021-06-09 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility.
Sci Immunol, 7, 2022
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6TKF
 | | ChiLob 7/4 H2 HC-C225S KappaLC-C214S F(ab')2 | | Descriptor: | ChiLob 7/4 H2 Heavy chain C225S, ChiLob 7/4 H2 Kappa light chain C214S | | Authors: | Orr, C.M, Fisher, H, Tews, I. | | Deposit date: | 2019-11-28 | | Release date: | 2021-06-09 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility.
Sci Immunol, 7, 2022
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7T84
 | | Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 G26D T57I variant | | Descriptor: | CITRIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Nemeth, G.R, Skiba, M.A, Kruse, A.C. | | Deposit date: | 2021-12-15 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | An in silico method to assess antibody fragment polyreactivity.
Nat Commun, 13, 2022
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