8FIS

Structure of Bispecific CAP256V2LS-J3 Fab in complex with BG505 DS-SOSIP.664

Summary for 8FIS

• Entry DOI: 10.2210/pdb8fis/pdb
• EMDB information: 29209
• Descriptor: Envelope glycoprotein gp41, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... (10 entities in total)
• Functional Keywords: cd4, hiv-1, sosip, vaccine, immune system, llama, v2 apex, therapeutic, viral protein, cap256, vrc26.25
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 10
• Total formula weight: 381232.65

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2022-12-16, release date: 2023-02-01, Last modification date: 2023-02-15)

• Primary citation: Zhang, B.,Gorman, J.,Kwon, Y.D.,Pegu, A.,Chao, C.W.,Liu, T.,Asokan, M.,Bender, M.F.,Bylund, T.,Damron, L.,Gollapudi, D.,Lei, P.,Li, Y.,Liu, C.,Louder, M.K.,McKee, K.,Olia, A.S.,Rawi, R.,Schon, A.,Wang, S.,Yang, E.S.,Yang, Y.,Carlton, K.,Doria-Rose, N.A.,Shapiro, L.,Seaman, M.S.,Mascola, J.R.,Kwong, P.D.; Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency.; Mabs, 15:2165390-2165390, 2023; PubMed: 36729903; DOI: 10.1080/19420862.2023.2165390

Experimental method

ELECTRON MICROSCOPY (3.18 Å)