8FIS
Structure of Bispecific CAP256V2LS-J3 Fab in complex with BG505 DS-SOSIP.664
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D (A, B, E) | Envelope glycoprotein gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) Pfam (PF00517) | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | C, E, F (C, F, G) | Envelope glycoprotein gp120 | polymer | 481 | 54086.3 | 3 | UniProt (Q2N0S6) Pfam (PF00516) | Human immunodeficiency virus 1 | Env polyprotein |
| 3 | G, H, J (J, I, L) | J3-VRC26.25 Light | polymer | 353 | 37355.2 | 3 | Lama glama | ||
| 4 | I (H) | VRC26.25 Heavy | polymer | 247 | 26863.0 | 1 | Homo sapiens | ||
| 5 | AA, K, KA, MA, NA... (a, D, k, m, n...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 8 | In PDB GlyTouCan (G15407YE) | |||
| 6 | BA, DA, FA, GA, HA... (b, d, f, g, h...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 22 | In PDB GlyTouCan (G42666HT) | |||
| 7 | CA, M, PA (c, M, p) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 8 | EA, O, RA (e, O, r) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G22573RC) | |||
| 9 | T, WA, X, Y, YA (T, w, X, Y, y) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 5 | In PDB GlyTouCan (G22768VO) | |||
| 10 | AB, BB, CB, DB, EB... (A, B, C, E, F...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 25 | Chemie (NAG) |
Sequence modifications
A, B, E: 512 - 664 (UniProt: Q2N0S6)
C, F, G: 31 - 513 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | conflict |
| Cys 605 | Thr 602 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Cys 201 | Ile 200 | conflict |
| Asn 332 | Thr 330 | conflict |
| Cys 433 | Ala 430 | conflict |
| Cys 501 | Ala 498 | conflict |
| Arg 509 | Glu 506 | conflict |
| Arg 510 | Lys 507 | conflict |
| Arg 512 | Ala 509 | conflict |
| Arg 513 | Val 510 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 352627.1 | |
| Branched | Number of molecules | 41 |
| Total formula weight | 23075.4 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 5530.2 | |
| All* | Total formula weight | 381232.7 |
