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7U2I
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BU of 7u2i by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Syroegin, E.A, Aleksandrova, E.V, Polikanov, Y.S.
Deposit date:2022-02-24
Release date:2022-07-13
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine.
Nucleic Acids Res., 50, 2022
4S0P
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BU of 4s0p by Molmil
Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (II)
Descriptor: Apoptosis regulator BAX
Authors:Priyadarshi, A, Gavathiotis, E.
Deposit date:2015-01-04
Release date:2016-07-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.252 Å)
Cite:An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
Mol.Cell, 63, 2016
6H9M
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BU of 6h9m by Molmil
Coiled-coil domain-containing protein 90B residues 43-125 from Homo sapiens fused to a GCN4 adaptor
Descriptor: Coiled-coil domain-containing protein 90B, mitochondrial,General control protein GCN4
Authors:Adlakha, J, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D.
Deposit date:2018-08-04
Release date:2019-02-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization of MCU-Binding Proteins MCUR1 and CCDC90B - Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles.
Structure, 27, 2019
5DC3
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BU of 5dc3 by Molmil
Complex of yeast 80S ribosome with non-modified eIF5A
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M.
Deposit date:2015-08-23
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome.
J.Mol.Biol., 428, 2016
8B6H
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BU of 8b6h by Molmil
Cryo-EM structure of cytochrome c oxidase dimer (complex IV) from respiratory supercomplex of Tetrahymena thermophila
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, ...
Authors:Muhleip, A, Kock Flygaard, R, Amunts, A.
Deposit date:2022-09-27
Release date:2023-03-29
Last modified:2023-04-12
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis of mitochondrial membrane bending by the I-II-III 2 -IV 2 supercomplex.
Nature, 615, 2023
8B7Q
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BU of 8b7q by Molmil
Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor
Authors:Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:2022-09-30
Release date:2023-04-05
Last modified:2023-04-26
Method:ELECTRON MICROSCOPY (4.02 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
4TRU
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BU of 4tru by Molmil
Crystal structure of Q24A Q25A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2014-06-17
Release date:2015-09-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
4S0O
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BU of 4s0o by Molmil
Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (I)
Descriptor: Apoptosis regulator BAX
Authors:Priyadarshi, A, Gavathiotis, E.
Deposit date:2015-01-02
Release date:2016-07-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
Mol.Cell, 63, 2016
4TRK
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BU of 4trk by Molmil
Structure of C. elegans HIM-3
Descriptor: C. elegans HIM-3
Authors:Rosenberg, S.C, Corbett, K.D.
Deposit date:2014-06-17
Release date:2014-11-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins.
Dev.Cell, 31, 2014
7U2H
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BU of 7u2h by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Syroegin, E.A, Aleksandrova, E.V, Polikanov, Y.S.
Deposit date:2022-02-24
Release date:2022-07-13
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine.
Nucleic Acids Res., 50, 2022
2XD7
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BU of 2xd7 by Molmil
Crystal structure of the macro domain of human core histone H2A
Descriptor: CORE HISTONE MACRO-H2A.2
Authors:Vollmar, M, Phillips, C, Carpenter, E.P, Muniz, J.R.C, Krojer, T, Ugochukwu, E, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Gileadi, O.
Deposit date:2010-04-29
Release date:2010-05-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal Structure of the Macro Domain of Human Core Histone H2A
To be Published
4TSX
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BU of 4tsx by Molmil
HIV-1 Integrase Catalytic Core Domain Mutant Complexed with Allosteric Inhibitor
Descriptor: (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, Integrase, SULFATE ION
Authors:Feng, L, Kvaratskhelia, M.
Deposit date:2014-06-19
Release date:2014-12-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:The mechanism of H171T resistance reveals the importance of N -protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.
Retrovirology, 11, 2014
8AVD
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BU of 8avd by Molmil
Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement)
Descriptor: Leptin, Leptin receptor, NICKEL (II) ION
Authors:Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:2022-08-26
Release date:2023-04-05
Last modified:2023-04-26
Method:ELECTRON MICROSCOPY (4.42 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVC
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BU of 8avc by Molmil
Mouse leptin:LEP-R complex cryoEM structure (3:3 model)
Descriptor: Leptin, Leptin receptor, NICKEL (II) ION
Authors:Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:2022-08-26
Release date:2023-04-05
Last modified:2023-04-26
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
1ZXF
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BU of 1zxf by Molmil
Solution structure of a self-sacrificing resistance protein, CalC from Micromonospora echinospora
Descriptor: CalC
Authors:Singh, S, Hager, M.H, Zhang, C, Griffith, B.R, Lee, M.S, Hallenga, K, Markley, J.L, Thorson, J.S, Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2005-06-08
Release date:2005-12-13
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural insight into the self-sacrifice mechanism of enediyne resistance.
Acs Chem.Biol., 1, 2006
4U4I
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BU of 4u4i by Molmil
Megavirus chilensis superoxide dismutase
Descriptor: Cu/Zn superoxide dismutase
Authors:Lartigue, A, Claverie, J.-M, Burlat, B, Coutard, B, Abergel, C.
Deposit date:2014-07-23
Release date:2014-11-05
Last modified:2014-12-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The megavirus chilensis cu,zn-superoxide dismutase: the first viral structure of a typical cellular copper chaperone-independent hyperstable dimeric enzyme.
J.Virol., 89, 2015
6BSY
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BU of 6bsy by Molmil
HIV-1 Rev assembly domain (residues 1-69)
Descriptor: PHOSPHATE ION, Protein Rev
Authors:Watts, N.R, Eren, E, Zhuang, X, Wang, Y.X, Steven, A.C, Wingfield, P.T.
Deposit date:2017-12-04
Release date:2018-04-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A new HIV-1 Rev structure optimizes interaction with target RNA (RRE) for nuclear export.
J. Struct. Biol., 203, 2018
6HN5
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BU of 6hn5 by Molmil
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ...
Authors:Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C.
Deposit date:2018-09-14
Release date:2018-11-21
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
8IXJ
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BU of 8ixj by Molmil
Middle segment of the bacteriophage M13 mini variant
Descriptor: Capsid protein G8P
Authors:Xiang, Y, Jia, Q.
Deposit date:2023-04-01
Release date:2023-08-16
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure of a bacteriophage M13 mini variant.
Nat Commun, 14, 2023
6E1Z
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BU of 6e1z by Molmil
Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
Descriptor: 5-[(1H-imidazol-1-yl)methyl]furan-2-carboxylic acid, WD repeat-containing protein 5
Authors:Phan, J, Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
2Z7L
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BU of 2z7l by Molmil
Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid
Descriptor: BETA-MERCAPTOETHANOL, Mitogen-activated protein kinase 1, SULFATE ION, ...
Authors:Katayama, N, Kurihara, H.
Deposit date:2007-08-27
Release date:2008-08-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors
Proteins, 73, 2008
6E23
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BU of 6e23 by Molmil
Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-[(3,4-dichlorophenyl)methyl]-3-(6-fluoro-2-methylpyridin-3-yl)-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}benzamide, WD repeat-containing protein 5
Authors:Phan, J, Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E22
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BU of 6e22 by Molmil
Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
Descriptor: 3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}-N-[(3,5-dimethoxyphenyl)methyl]-4-fluorobenzamide, SULFATE ION, WD repeat-containing protein 5
Authors:Phan, J, Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
8IXK
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BU of 8ixk by Molmil
bottom segment of the bacteriophage M13 mini variant
Descriptor: Attachment protein G3P, Capsid protein G8P, Head virion protein G6P
Authors:Xiang, Y, Jia, Q.
Deposit date:2023-04-01
Release date:2023-09-13
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of a bacteriophage M13 mini variant.
Nat Commun, 14, 2023
4U4A
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BU of 4u4a by Molmil
Complex Structure of BRCA1 BRCT with singly phospho Abraxas
Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein
Authors:Badgujar, D, Hosur, M.V, Varma, A.K.
Deposit date:2014-07-23
Release date:2015-08-26
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Complex Structure of BRCA1 BRCT with singly phospho Abraxas
To Be Published

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