4S0O
Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (I)
Summary for 4S0O
| Entry DOI | 10.2210/pdb4s0o/pdb |
| Related | 1F16 4S0P |
| Descriptor | Apoptosis regulator BAX (2 entities in total) |
| Functional Keywords | bcl-2 family protein, apoptosis regulator, autoinhibited dimer, apoptosis |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm : Q07812 |
| Total number of polymer chains | 2 |
| Total formula weight | 42328.58 |
| Authors | Priyadarshi, A.,Gavathiotis, E. (deposition date: 2015-01-02, release date: 2016-07-20, Last modification date: 2023-09-20) |
| Primary citation | Garner, T.P.,Reyna, D.E.,Priyadarshi, A.,Chen, H.C.,Li, S.,Wu, Y.,Ganesan, Y.T.,Malashkevich, V.N.,Almo, S.S.,Cheng, E.H.,Gavathiotis, E. An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway. Mol.Cell, 63:485-497, 2016 Cited by PubMed: 27425408DOI: 10.1016/j.molcel.2016.06.010 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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