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4S0O

Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (I)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001783biological_processB cell apoptotic process
A0001836biological_processrelease of cytochrome c from mitochondria
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005757cellular_componentmitochondrial permeability transition pore complex
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0006915biological_processapoptotic process
A0008053biological_processmitochondrial fusion
A0008289molecular_functionlipid binding
A0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0008637biological_processapoptotic mitochondrial changes
A0009636biological_processresponse to toxic substance
A0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
A0010917biological_processnegative regulation of mitochondrial membrane potential
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0030544molecular_functionHsp70 protein binding
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031966cellular_componentmitochondrial membrane
A0032091biological_processnegative regulation of protein binding
A0032469biological_processendoplasmic reticulum calcium ion homeostasis
A0032976biological_processrelease of matrix enzymes from mitochondria
A0033554biological_processcellular response to stress
A0034620biological_processcellular response to unfolded protein
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0043653biological_processmitochondrial fragmentation involved in apoptotic process
A0046930cellular_componentpore complex
A0046982molecular_functionprotein heterodimerization activity
A0051087molecular_functionprotein-folding chaperone binding
A0051434molecular_functionBH3 domain binding
A0051881biological_processregulation of mitochondrial membrane potential
A0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A0070062cellular_componentextracellular exosome
A0071944cellular_componentcell periphery
A0090200biological_processpositive regulation of release of cytochrome c from mitochondria
A0097136cellular_componentBcl-2 family protein complex
A0097144cellular_componentBAX complex
A0097145cellular_componentBAK complex
A0097190biological_processapoptotic signaling pathway
A0097191biological_processextrinsic apoptotic signaling pathway
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097193biological_processintrinsic apoptotic signaling pathway
A0097194biological_processexecution phase of apoptosis
A0097435biological_processsupramolecular fiber organization
A0098586biological_processcellular response to virus
A1902512biological_processpositive regulation of apoptotic DNA fragmentation
A1902531biological_processregulation of intracellular signal transduction
A1903896biological_processpositive regulation of IRE1-mediated unfolded protein response
A1990117biological_processB cell receptor apoptotic signaling pathway
A2001233biological_processregulation of apoptotic signaling pathway
A2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
B0001783biological_processB cell apoptotic process
B0001836biological_processrelease of cytochrome c from mitochondria
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005757cellular_componentmitochondrial permeability transition pore complex
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0008053biological_processmitochondrial fusion
B0008289molecular_functionlipid binding
B0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0008637biological_processapoptotic mitochondrial changes
B0009636biological_processresponse to toxic substance
B0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
B0010917biological_processnegative regulation of mitochondrial membrane potential
B0015267molecular_functionchannel activity
B0016020cellular_componentmembrane
B0030544molecular_functionHsp70 protein binding
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031966cellular_componentmitochondrial membrane
B0032091biological_processnegative regulation of protein binding
B0032469biological_processendoplasmic reticulum calcium ion homeostasis
B0032976biological_processrelease of matrix enzymes from mitochondria
B0033554biological_processcellular response to stress
B0034620biological_processcellular response to unfolded protein
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0043525biological_processpositive regulation of neuron apoptotic process
B0043653biological_processmitochondrial fragmentation involved in apoptotic process
B0046930cellular_componentpore complex
B0046982molecular_functionprotein heterodimerization activity
B0051087molecular_functionprotein-folding chaperone binding
B0051434molecular_functionBH3 domain binding
B0051881biological_processregulation of mitochondrial membrane potential
B0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
B0070062cellular_componentextracellular exosome
B0071944cellular_componentcell periphery
B0090200biological_processpositive regulation of release of cytochrome c from mitochondria
B0097136cellular_componentBcl-2 family protein complex
B0097144cellular_componentBAX complex
B0097145cellular_componentBAK complex
B0097190biological_processapoptotic signaling pathway
B0097191biological_processextrinsic apoptotic signaling pathway
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0097193biological_processintrinsic apoptotic signaling pathway
B0097194biological_processexecution phase of apoptosis
B0097435biological_processsupramolecular fiber organization
B0098586biological_processcellular response to virus
B1902512biological_processpositive regulation of apoptotic DNA fragmentation
B1902531biological_processregulation of intracellular signal transduction
B1903896biological_processpositive regulation of IRE1-mediated unfolded protein response
B1990117biological_processB cell receptor apoptotic signaling pathway
B2001233biological_processregulation of apoptotic signaling pathway
B2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues20
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. MFsDGnfNWGRVVALFyFAS
ChainResidueDetails
AMET99-SER118

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdqGGWDgLL
ChainResidueDetails
ATRP151-LEU162

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. LsecLKrIGDELDSN
ChainResidueDetails
ALEU59-ASN73

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues28
DetailsMotif: {"description":"BH3","evidences":[{"source":"PubMed","id":"8521816","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues40
DetailsMotif: {"description":"BH1"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues30
DetailsMotif: {"description":"BH2"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36361894","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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