4TSX

HIV-1 Integrase Catalytic Core Domain Mutant Complexed with Allosteric Inhibitor

Summary for 4TSX

• Entry DOI: 10.2210/pdb4tsx/pdb
• Related: 1ITG
• Descriptor: Integrase, (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hiv integrase, ccd, h171t, dde motif, dimer interface, allosteric inhibitor, allini, quinoline, dna binding protein
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 18713.01

Authors

Feng, L.,Kvaratskhelia, M. (deposition date: 2014-06-19, release date: 2014-12-17, Last modification date: 2023-12-27)

• Primary citation: Slaughter, A.,Jurado, K.A.,Deng, N.,Feng, L.,Kessl, J.J.,Shkriabai, N.,Larue, R.C.,Fadel, H.J.,Patel, P.A.,Jena, N.,Fuchs, J.R.,Poeschla, E.,Levy, R.M.,Engelman, A.,Kvaratskhelia, M.; The mechanism of H171T resistance reveals the importance of N -protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.; Retrovirology, 11:100-100, 2014; PubMed: 25421939; DOI: 10.1186/s12977-014-0100-1

Experimental method

X-RAY DIFFRACTION (1.94 Å)