4TSX
HIV-1 Integrase Catalytic Core Domain Mutant Complexed with Allosteric Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrase | polymer | 163 | 18115.4 | 1 | UniProt (F2WR39) Pfam (PF00665) | Human immunodeficiency virus 1 | |
| 2 | B (A) | (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid | non-polymer | 405.5 | 1 | Chemie (LF0) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E (A) | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
A: 50 - 212 (UniProt: F2WR39)
| PDB | External Database | Details |
|---|---|---|
| Thr 171 | His 171 | engineered mutation |
| Lys 185 | Phe 185 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18115.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 597.6 | |
| All* | Total formula weight | 18713.0 |
