PDB: 594 resultsInfo pagesStatus searchChemie searchBIRD

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3K2M	Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex Descriptor: Monobody HA4, PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase ABL1 Authors: Wojcik, J.B, Duguid, E. Deposit date: 2009-09-30 Release date: 2010-03-31 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat.Struct.Mol.Biol., 17, 2010
3KFJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... Authors: Clements, J.H. Deposit date: 2009-10-27 Release date: 2010-03-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization. J.Am.Chem.Soc., 131, 2009
3M7F	Crystal structure of the Nedd4 C2/Grb10 SH2 complex Descriptor: E3 ubiquitin-protein ligase NEDD4, Growth factor receptor-bound protein 10 Authors: Huang, Q, Szebenyi, M. Deposit date: 2010-03-16 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4. J.Biol.Chem., 285, 2010
3MAZ	Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide Descriptor: CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1 Authors: Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S. Deposit date: 2010-03-24 Release date: 2010-05-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Loops govern SH2 domain specificity by controlling access to binding pockets. Sci.Signal., 3, 2010
3MXC	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-07 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
3MXY	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide E683V variant, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-08 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
3N7Y	Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV Descriptor: 20-membered peptide-like macrocyclic ligand, Growth factor receptor-bound protein 2 Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP Descriptor: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-28 Release date: 2010-12-15 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3NHN	Crystal structure of the SRC-family kinase HCK SH3-SH2-linker regulatory region Descriptor: Tyrosine-protein kinase HCK Authors: Alvarado, J.J, Betts, L, Moroco, J.A, Smithgall, T.E, Yeh, J.I. Deposit date: 2010-06-14 Release date: 2010-09-01 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism. J.Biol.Chem., 285, 2010
3OV1	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: FORMIC ACID, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-15 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3OVE	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-16 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
2L3T	Solution structure of tandem SH2 domain from Spt6 Descriptor: Transcription elongation factor SPT6 Authors: Liu, J, Zhang, J, Wu, J, Shi, Y. Deposit date: 2010-09-22 Release date: 2011-06-15 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution structure of the tandem SH2 domains from Spt6 and their binding to the phosphorylated RNA polymerase II C-terminal domain To be Published
2L4K	Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139 Descriptor: Growth factor receptor-bound protein 7, Receptor tyrosine-protein kinase erbB-2 Authors: Pias, S.C, Ivancic, M, Brescia, P.J, Johnson, D.L, Smith, D.E, Daly, R.J, Lyons, B.A. Deposit date: 2010-10-07 Release date: 2010-11-17 Last modified: 2012-10-03 Method: SOLUTION NMR Cite: Water-Refined Solution Structure of the Human Grb7-SH2 Domain in Complex with the erbB2 Receptor Peptide pY1139. Protein Pept.Lett., 19, 2012
2L6K	Solution Structure of a Nonphosphorylated Peptide Recognizing Domain Descriptor: Tensin-like C1 domain-containing phosphatase Authors: Dai, K, Liao, S, Zhang, J, Zhang, X, Tu, X. Deposit date: 2010-11-22 Release date: 2011-10-12 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution structure of Tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1 Plos One, 6, 2011
3PQZ	Grb7 SH2 with peptide Descriptor: Growth factor receptor-bound protein 7, cyclic peptide Authors: Wilce, J.A. Deposit date: 2010-11-29 Release date: 2011-07-20 Last modified: 2011-09-21 Method: X-RAY DIFFRACTION (2.413 Å) Cite: Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression J.Mol.Biol., 412, 2011
3PS5	Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1 Descriptor: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Wang, W, Liu, L, Song, X, Mo, Y, Komma, C, Bellamy, H.D, Zhao, Z.J, Zhou, G.W. Deposit date: 2010-11-30 Release date: 2011-04-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation. J.Cell.Biochem., 112, 2011
3PSI	Crystal Structure of the Spt6 core domain from Saccharomyces cerevisiae, Form Spt6(239-1451) Descriptor: Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P, Johnson, S.J. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2011-08-03 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3PSJ	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Se-Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.702 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3PSK	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Native Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
2Y3A	Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 Descriptor: 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM Authors: Zhang, X, Vadas, O, Perisic, O, Williams, R.L. Deposit date: 2010-12-20 Release date: 2011-03-16 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism. Mol.Cell, 41, 2011
3QWX	CED-2 1-174 Descriptor: Cell death abnormality protein 2, SULFATE ION Authors: Kang, Y, Sun, J, Liu, Y. Deposit date: 2011-02-28 Release date: 2011-06-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
3QWY	CED-2 Descriptor: Cell death abnormality protein 2, GLYCEROL, SULFATE ION Authors: Kang, Y, Sun, J, Liu, Y, Sun, D, Hu, Y, Liu, Y.F. Deposit date: 2011-02-28 Release date: 2011-06-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
2LCT	Solution structure of the Vav1 SH2 domain complexed with a Syk-derived doubly phosphorylated peptide Descriptor: Proto-oncogene vav, Tyrosine-protein kinase SYK Authors: Chen, C, Gorenstein, N, Post, C. Deposit date: 2011-05-09 Release date: 2011-06-01 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav. Mol.Cell.Biol., 31, 2011
3S8N	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011

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