2L4K
Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139
Summary for 2L4K
| Entry DOI | 10.2210/pdb2l4k/pdb |
| Related | 1MW4 2QMS |
| Descriptor | Growth factor receptor-bound protein 7, Receptor tyrosine-protein kinase erbB-2 (2 entities in total) |
| Functional Keywords | grb7, sh2 domain, erbb2 receptor, water refinement, signaling protein |
| Biological source | Homo sapiens (human) More |
| Cellular location | Cytoplasm: Q14451 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626 |
| Total number of polymer chains | 2 |
| Total formula weight | 14956.92 |
| Authors | Pias, S.C.,Ivancic, M.,Brescia, P.J.,Johnson, D.L.,Smith, D.E.,Daly, R.J.,Lyons, B.A. (deposition date: 2010-10-07, release date: 2010-11-17, Last modification date: 2012-10-03) |
| Primary citation | Pias, S.C.,Johnson, D.L.,Smith, D.E.,Lyons, B.A. Water-Refined Solution Structure of the Human Grb7-SH2 Domain in Complex with the erbB2 Receptor Peptide pY1139. Protein Pept.Lett., 19:832-838, 2012 Cited by PubMed: 22702899PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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