2L4K

Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139

Summary for 2L4K

• Entry DOI: 10.2210/pdb2l4k/pdb
• Related: 1MW4 2QMS
• Descriptor: Growth factor receptor-bound protein 7, Receptor tyrosine-protein kinase erbB-2 (2 entities in total)
• Functional Keywords: grb7, sh2 domain, erbb2 receptor, water refinement, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q14451; Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
• Total number of polymer chains: 2
• Total formula weight: 14956.92

Authors

Pias, S.C.,Ivancic, M.,Brescia, P.J.,Johnson, D.L.,Smith, D.E.,Daly, R.J.,Lyons, B.A. (deposition date: 2010-10-07, release date: 2010-11-17, Last modification date: 2024-11-06)

Primary citation

Pias, S.C.,Johnson, D.L.,Smith, D.E.,Lyons, B.A.
Water-Refined Solution Structure of the Human Grb7-SH2 Domain in Complex with the erbB2 Receptor Peptide pY1139.
Protein Pept.Lett., 19:832-838, 2012

PubMed Abstract: We report a refinement in implicit water of the previously published solution structure of the Grb7-SH2 domain bound to the erbB2 receptor peptide pY1139. Structure quality measures indicate substantial improvement, with residues in the most favored regions of the Ramachandran plot increasing by 14 % and with WHAT IF statistics (Vriend, G. J. Mol. Graph., 1990, 8(1), 52-56) falling closer to expected values for well-refined structures.

PubMed: 22702899

Experimental method

SOLUTION NMR