2Y3A

Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941

Summary for 2Y3A

• Entry DOI: 10.2210/pdb2y3a/pdb
• Descriptor: PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (3 entities in total)
• Functional Keywords: transferase, phosphoinositide 3-kinase, rtk
• Biological source: MUS MUSCULUS (MOUSE); More
• Total number of polymer chains: 2
• Total formula weight: 161102.28

Authors

Zhang, X.,Vadas, O.,Perisic, O.,Williams, R.L. (deposition date: 2010-12-20, release date: 2011-03-16, Last modification date: 2023-12-20)

• Primary citation: Zhang, X.,Vadas, O.,Perisic, O.,Anderson, K.E.,Clark, J.,Hawkins, P.T.,Stephens, L.R.,Williams, R.L.; Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism.; Mol.Cell, 41:567-, 2011; PubMed: 21362552; DOI: 10.1016/J.MOLCEL.2011.01.026

Experimental method

X-RAY DIFFRACTION (3.3 Å)