2Y3A
Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941
Summary for 2Y3A
Entry DOI | 10.2210/pdb2y3a/pdb |
Descriptor | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (3 entities in total) |
Functional Keywords | transferase, phosphoinositide 3-kinase, rtk |
Biological source | MUS MUSCULUS (MOUSE) More |
Total number of polymer chains | 2 |
Total formula weight | 161102.28 |
Authors | Zhang, X.,Vadas, O.,Perisic, O.,Williams, R.L. (deposition date: 2010-12-20, release date: 2011-03-16, Last modification date: 2023-12-20) |
Primary citation | Zhang, X.,Vadas, O.,Perisic, O.,Anderson, K.E.,Clark, J.,Hawkins, P.T.,Stephens, L.R.,Williams, R.L. Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism. Mol.Cell, 41:567-, 2011 Cited by PubMed: 21362552DOI: 10.1016/J.MOLCEL.2011.01.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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