2Y3A
Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM | polymer | 1092 | 125242.1 | 1 | UniProt (Q8BTI9) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | MUS MUSCULUS (MOUSE) | PI3-KINASE SUBUNIT BETA, PI3K-BETA, PTDINS-3-KINASE SUBUNIT BETA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE 110 KDA CATALYTIC SUBUNIT BETA, PTDINS-3-KINASE SUBUNIT P110-BETA, PIK3CA |
| 2 | B (B) | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA | polymer | 302 | 35346.6 | 1 | UniProt (O08908) Pfam (PF16454) Pfam (PF00017) | MUS MUSCULUS (MOUSE) | PI3-KINASE REGULATORY SUBUNIT BETA, PI3K REGULATORY SUBUNIT BETA, PTDINS-3-KINASE REGULATORY SUBUNIT BETA, PHOSPHATIDYLINOSITOL 3-KINASE 85 KDA REGULATORY SUBUNIT BETA, PI3-KINASE SUBUNIT P85-BETA, PTDINS-3-KINASE REGULATORY SUBUNIT P85-BETA, PIK3R2 |
| 3 | C (A) | 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine | non-polymer | 513.6 | 1 | Chemie (GD9) |
Sequence modifications
A: 1 - 1064 (UniProt: Q8BTI9)
B: 423 - 722 (UniProt: O08908)
| PDB | External Database | Details |
|---|---|---|
| Met -27 | - | expression tag |
| Ser -26 | - | expression tag |
| Tyr -25 | - | expression tag |
| Tyr -24 | - | expression tag |
| His -23 | - | expression tag |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Tyr -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Ile -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Thr -12 | - | expression tag |
| Thr -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Asn -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 123 | Arg 123 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 421 | - | expression tag |
| Ser 422 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 160588.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 513.6 | |
| All* | Total formula weight | 161102.3 |
