4EA3
| Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)propyl]-D-prolinamide, ... | Authors: | Thompson, A.A, Liu, W, Chun, E, Katritch, V, Wu, H, Vardy, E, Huang, X.P, Trapella, C, Guerrini, R, Calo, G, Roth, B.L, Cherezov, V, Stevens, R.C, GPCR Network (GPCR) | Deposit date: | 2012-03-22 | Release date: | 2012-04-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.013 Å) | Cite: | Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature, 485, 2012
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8X2K
| a lipid receptor complex structure | Descriptor: | (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Geng, C, Yang, D, Jun, X. | Deposit date: | 2023-11-09 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | a lipid receptor complex structure To Be Published
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6M97
| Crystal structure of the high-affinity copper transporter Ctr1 | Descriptor: | Chimera protein of High affinity copper uptake protein 1 and Soluble cytochrome b562, HEXATANTALUM DODECABROMIDE, ZINC ION | Authors: | Ren, F, Yuan, P. | Deposit date: | 2018-08-22 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | X-ray structures of the high-affinity copper transporter Ctr1. Nat Commun, 10, 2019
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8HVI
| Activation mechanism of GPR132 by compound NOX-6-7 | Descriptor: | 3-methyl-5-[(4-oxidanylidene-4-phenyl-butanoyl)amino]-1-benzofuran-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | Deposit date: | 2022-12-26 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8DR8
| LRRC8A:C conformation 2 (oblong) top mask | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-07-20 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8K9L
| Full agonist- and positive allosteric modulator-bound mu-type opioid receptor-G protein complex | Descriptor: | (2~{S})-2-(3-bromanyl-4-methoxy-phenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine, DAMGO, G protein subunit alpha i3, ... | Authors: | Hisano, T, Uchikubo-Kamo, T, Shirouzu, M, Imai, S, Kaneko, S, Shimada, I. | Deposit date: | 2023-08-01 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Structural and dynamic insights into the activation of the mu-opioid receptor by an allosteric modulator. Nat Commun, 15, 2024
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8IHH
| Cryo-EM structure of HCA2-Gi complex with LUF6283 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-butyl-1~{H}-pyrazole-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | Deposit date: | 2023-02-22 | Release date: | 2023-08-30 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
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8IHJ
| Cryo-EM structure of HCA3-Gi complex with acifran | Descriptor: | (5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | Deposit date: | 2023-02-22 | Release date: | 2023-08-30 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
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8DS3
| LRRC8A:C conformation 1 (round) | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-07-21 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8ZSS
| Cryo-EM structure of the RO5263397-bound hTAAR1-Gs complex | Descriptor: | (4~{S})-4-(3-fluoranyl-2-methyl-phenyl)-1,3-oxazolidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Jiang, K.X, Zheng, Y, Xu, F. | Deposit date: | 2024-06-05 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules. Cell Rep, 43, 2024
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8HS2
| Orphan GPR20 in complex with Fab046 | Descriptor: | Light chain of Fab046, Soluble cytochrome b562,G-protein coupled receptor 20, heavy chain of Fab046 | Authors: | Lin, X, Jiang, S, Xu, F. | Deposit date: | 2022-12-16 | Release date: | 2023-03-08 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
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7WVW
| Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2 | Descriptor: | FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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8F74
| LRRC8A(T48D):C conformation 2 top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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7XZ5
| GPR119-Gs-LPC complex | Descriptor: | (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | Deposit date: | 2022-06-02 | Release date: | 2022-08-24 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7DFP
| Human dopamine D2 receptor in complex with spiperone | Descriptor: | 8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, D(2) dopamine receptor,Soluble cytochrome b562, FabH, ... | Authors: | Im, D, Shimamura, T, Iwata, S. | Deposit date: | 2020-11-09 | Release date: | 2020-12-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the dopamine D 2 receptor in complex with the antipsychotic drug spiperone. Nat Commun, 11, 2020
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8ZFJ
| cryo-EM structure of GPR4-Gs complex at pH 8.5 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Ma, Y, Tang, M, Ru, H, Song, G. | Deposit date: | 2024-05-07 | Release date: | 2024-08-07 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | cryo-EM structure of GPR4-Gs complex at pH 8.5 to be published
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7Y13
| Cryo-EM structure of apo-state MrgD-Gi complex (local) | Descriptor: | PALMITIC ACID, Soluble cytochrome b562,Mas-related G-protein coupled receptor member D | Authors: | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | Deposit date: | 2022-06-06 | Release date: | 2022-07-20 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
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7Y12
| Cryo-EM structure of MrgD-Gi complex with beta-alanine | Descriptor: | BETA-ALANINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | Deposit date: | 2022-06-06 | Release date: | 2022-07-20 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
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5OLO
| Structure of the A2A-StaR2-bRIL562-Tozadenant complex at 3.1A obtained from in meso soaking experiments. | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... | Authors: | Rucktooa, P, Cheng, R.K.Y, Segala, E, Geng, T, Errey, J.C, Brown, G.A, Cooke, R, Marshall, F.H, Dore, A.S. | Deposit date: | 2017-07-28 | Release date: | 2018-01-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals. Sci Rep, 8, 2018
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7X5H
| Serotonin 5A (5-HT5A) receptor-Gi protein complex | Descriptor: | 3-(2-azanylethyl)-1H-indole-5-carboxamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Tan, Y, Xu, P, Huang, S, Xu, H.E, Jiang, Y. | Deposit date: | 2022-03-04 | Release date: | 2022-09-14 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into the ligand binding and G i coupling of serotonin receptor 5-HT 5A . Cell Discov, 8, 2022
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8IRV
| Dopamine Receptor D5R-Gs-Rotigotine complex | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | Deposit date: | 2023-03-19 | Release date: | 2023-06-07 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
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8JLJ
| T1AM-bound mTAAR1-Gs protein complex | Descriptor: | 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | Deposit date: | 2023-06-02 | Release date: | 2023-11-15 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature, 624, 2023
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7E2Z
| Aripiprazole-bound serotonin 1A (5-HT1A) receptor-Gi protein complex | Descriptor: | 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E. | Deposit date: | 2021-02-07 | Release date: | 2021-04-14 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into the lipid and ligand regulation of serotonin receptors. Nature, 592, 2021
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6DRX
| Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5HT2B receptor, BRIL chimera, ... | Authors: | McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L. | Deposit date: | 2018-06-13 | Release date: | 2018-08-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural determinants of 5-HT2Breceptor activation and biased agonism. Nat. Struct. Mol. Biol., 25, 2018
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7F4I
| Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35 | Descriptor: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. | Deposit date: | 2021-06-18 | Release date: | 2021-09-08 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
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