4EA3

Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic

Summary for 4EA3

• Entry DOI: 10.2210/pdb4ea3/pdb
• Descriptor: Fusion protein of Nociceptin receptor and cytochrome b562, 1-benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)propyl]-D-prolinamide, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total)
• Functional Keywords: psi-biology gpcr network, structural genomics, gpcr membrane protein 7tm nop orl1 cytochrome b562, receptor, nociceptin orphanin fq compound 24 opioid, fusion, membrane transmembrane, signaling protein
• Biological source: Escherichia coli; More
• Cellular location: Cell membrane; Multi-pass membrane protein: P41146
• Total number of polymer chains: 2
• Total formula weight: 98018.35

Authors

Thompson, A.A.,Liu, W.,Chun, E.,Katritch, V.,Wu, H.,Vardy, E.,Huang, X.P.,Trapella, C.,Guerrini, R.,Calo, G.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2012-03-22, release date: 2012-04-25, Last modification date: 2023-09-13)

• Primary citation: Thompson, A.A.,Liu, W.,Chun, E.,Katritch, V.,Wu, H.,Vardy, E.,Huang, X.P.,Trapella, C.,Guerrini, R.,Calo, G.,Roth, B.L.,Cherezov, V.,Stevens, R.C.; Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.; Nature, 485:395-399, 2012; PubMed: 22596163; DOI: 10.1038/nature11085

Experimental method

X-RAY DIFFRACTION (3.013 Å)