4EA3
Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001626 | molecular_function | nociceptin receptor activity |
A | 0004930 | molecular_function | G protein-coupled receptor activity |
A | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
A | 0009055 | molecular_function | electron transfer activity |
A | 0016020 | cellular_component | membrane |
A | 0020037 | molecular_function | heme binding |
A | 0022900 | biological_process | electron transport chain |
A | 0042597 | cellular_component | periplasmic space |
A | 0046872 | molecular_function | metal ion binding |
B | 0001626 | molecular_function | nociceptin receptor activity |
B | 0004930 | molecular_function | G protein-coupled receptor activity |
B | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
B | 0009055 | molecular_function | electron transfer activity |
B | 0016020 | cellular_component | membrane |
B | 0020037 | molecular_function | heme binding |
B | 0022900 | biological_process | electron transport chain |
B | 0042597 | cellular_component | periplasmic space |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 0NN A 1501 |
Chain | Residue |
A | GLN107 |
A | GLN280 |
A | VAL283 |
A | TYR309 |
A | ASP130 |
A | TYR131 |
A | MET134 |
A | PHE135 |
A | LEU201 |
A | ILE219 |
A | SER223 |
A | TRP276 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE OLB A 1502 |
Chain | Residue |
A | TYR89 |
A | ASP147 |
A | VAL150 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE OLA A 1503 |
Chain | Residue |
A | VAL55 |
A | THR109 |
A | LEU112 |
A | LEU113 |
A | PHE115 |
A | PRO117 |
B | CYS70 |
B | TYR74 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 0NN B 1501 |
Chain | Residue |
B | GLN107 |
B | ASP110 |
B | ILE127 |
B | ASP130 |
B | TYR131 |
B | MET134 |
B | CYS200 |
B | ILE219 |
B | SER223 |
B | GLN280 |
B | VAL283 |
B | TYR309 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE OLC B 1502 |
Chain | Residue |
A | VAL281 |
A | VAL290 |
B | TYR89 |
B | ASP147 |
B | VAL161 |
B | LYS166 |
Functional Information from PROSITE/UniProt
site_id | PS00237 |
Number of Residues | 17 |
Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSTfTLTAMSVDRYVaI |
Chain | Residue | Details |
A | THR136-ILE152 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: axial binding residue |
Chain | Residue | Details |
A | TRP1007 | |
A | ILE1102 | |
B | TRP1007 | |
B | ILE1102 |
site_id | SWS_FT_FI2 |
Number of Residues | 50 |
Details | TRANSMEM: Helical; Name=1 |
Chain | Residue | Details |
A | GLY49-TYR74 | |
B | GLY49-TYR74 |
site_id | SWS_FT_FI3 |
Number of Residues | 114 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:22596163 |
Chain | Residue | Details |
A | VAL75-ASN87 | |
A | ASP147-SER165 | |
A | LEU237-LEU264 | |
B | VAL75-ASN87 | |
B | ASP147-SER165 | |
B | LEU237-LEU264 |
site_id | SWS_FT_FI4 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=2 |
Chain | Residue | Details |
A | ILE88-THR109 | |
B | ILE88-THR109 |
site_id | SWS_FT_FI5 |
Number of Residues | 100 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:22596163 |
Chain | Residue | Details |
A | ASP110-LYS124 | |
A | GLY189-TRP211 | |
A | GLN286-ILE300 | |
B | ASP110-LYS124 | |
B | GLY189-TRP211 | |
B | GLN286-ILE300 |
site_id | SWS_FT_FI6 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=3 |
Chain | Residue | Details |
A | THR125-VAL146 | |
B | THR125-VAL146 |
site_id | SWS_FT_FI7 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=4 |
Chain | Residue | Details |
A | LYS166-MET188 | |
B | LYS166-MET188 |
site_id | SWS_FT_FI8 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=5 |
Chain | Residue | Details |
A | GLY212-SER236 | |
B | GLY212-SER236 |
site_id | SWS_FT_FI9 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=6 |
Chain | Residue | Details |
A | VAL265-ALA285 | |
B | VAL265-ALA285 |
site_id | SWS_FT_FI10 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=7 |
Chain | Residue | Details |
A | LEU301-LEU322 | |
B | LEU301-LEU322 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | SITE: Important for G protein-mediated signaling |
Chain | Residue | Details |
A | ASP110 | |
A | ASP130 | |
B | ASP110 | |
B | ASP130 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
Chain | Residue | Details |
A | CYS334 | |
B | CYS334 |