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PDB: 74 results

4O6W
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BU of 4o6w by Molmil
Peptide-Based Inhibitors of Plk1 Polo-box Domain
Descriptor: Peptide-Based inhibitor, Serine/threonine-protein kinase PLK1
Authors:Qian, W.-J, Park, J.-E, Lim, D.C, Park, S.-Y, Lee, K.-W, Yaffe, M.B, Lee, K.S, Burke, T.R.
Deposit date:2013-12-23
Release date:2014-12-03
Method:X-RAY DIFFRACTION (1.448 Å)
Cite:Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells.
Biopolymers, 102, 2014
4O56
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BU of 4o56 by Molmil
Structure of PLK1 in complex with peptide
Descriptor: PHOSPHATE ION, Serine/threonine-protein kinase PLK1, synthetic peptide
Authors:Wang, T.
Deposit date:2013-12-19
Release date:2014-12-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Integration of Charge-dipole Interaction and Intramolecular Hydrogen Bond in Ligand Design for the Polo-Box Domain of Polo-like Kinase 1
To be Published
3FC2
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BU of 3fc2 by Molmil
PLK1 in complex with BI6727
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Bader, G.
Deposit date:2008-11-21
Release date:2009-05-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity.
Clin.Cancer Res., 15, 2009
4WHK
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BU of 4whk by Molmil
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Descriptor: C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR, Serine/threonine-protein kinase PLK1
Authors:Bang, J.K, Han, Y.H, Ahn, M.J, Lee, K.S.
Deposit date:2014-09-23
Release date:2014-12-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
J.Med.Chem., 58, 2015
4WHL
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BU of 4whl by Molmil
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Descriptor: C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR, Serine/threonine-protein kinase PLK1
Authors:Bang, J.K, Han, Y.H, Ahn, M.J, Lee, K.S.
Deposit date:2014-09-23
Release date:2014-12-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
J.Med.Chem., 58, 2015
4WHH
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BU of 4whh by Molmil
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Descriptor: C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR, SULFATE ION, Serine/threonine-protein kinase PLK1
Authors:Bang, J.K.
Deposit date:2014-09-22
Release date:2014-12-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
J.Med.Chem., 58, 2015
4J53
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BU of 4j53 by Molmil
Crystal structure of PLK1 in complex with TAK-960
Descriptor: 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide, ACETATE ION, Serine/threonine-protein kinase PLK1, ...
Authors:Hosfield, D.J, Skene, R.J.
Deposit date:2013-02-07
Release date:2013-05-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Bioorg.Med.Chem.Lett., 23, 2013
3HIH
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BU of 3hih by Molmil
Structure of human Plk1-PBD with glycerol and sulfate in the phophopeptide binding site
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ...
Authors:Wlodawer, A, Moulaei, T.
Deposit date:2009-05-20
Release date:2009-06-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nat.Struct.Mol.Biol., 16, 2009
3HIK
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BU of 3hik by Molmil
Structure of human Plk1-PBD in complex with PLHSpT
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Pentamer phosphopeptide, ...
Authors:Wlodawer, A, Moulaei, T.
Deposit date:2009-05-20
Release date:2009-06-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nat.Struct.Mol.Biol., 16, 2009
4X9V
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BU of 4x9v by Molmil
PLK-1 polo-box domain in complex with Bioactive Imidazolium-containing phosphopeptide macrocycle 3C
Descriptor: Phosphopeptide macrocycle 3C, Serine/threonine-protein kinase PLK1
Authors:Grant, R.A, Qian, W.-J, Yaffe, M.B, Burke, T.R.
Deposit date:2014-12-11
Release date:2015-07-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.429 Å)
Cite:Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
Biopolymers, 104, 2015
4LKM
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BU of 4lkm by Molmil
Crystal structure of Plk1 Polo-box domain in complex with PL-74
Descriptor: GLYCEROL, PL-74, SULFATE ION, ...
Authors:Lee, W.C, Song, J.H, Kim, H.Y.
Deposit date:2013-07-08
Release date:2013-12-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1
Plos One, 8, 2013
4LKL
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BU of 4lkl by Molmil
Crystal structure of Plk1 Polo-box domain in complex with PL-55
Descriptor: ADAMANTANE, PL-55, Serine/threonine-protein kinase PLK1
Authors:Lee, W.C, Song, J.H, Kim, H.Y.
Deposit date:2013-07-08
Release date:2013-12-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1
Plos One, 8, 2013
3FVH
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BU of 3fvh by Molmil
Polo-like kinase 1 Polo box domain in complex with Ac-LHSpTA-NH2 peptide
Descriptor: Acetyl-Leu-His-Ser-phosphoThr-Ala-NH2 peptide, Serine/threonine-protein kinase PLK1
Authors:Lim, D.C, Yaffe, M.B.
Deposit date:2009-01-15
Release date:2009-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
Nat.Struct.Mol.Biol., 16, 2009
4J52
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BU of 4j52 by Molmil
Crystal structure of PLK1 in complex with a pyrimidodiazepinone inhibitor
Descriptor: 4-{[(7R)-9-cyclopentyl-7-ethenyl-7-fluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl]amino}-3-methoxy-N-(4-methylpiperazin-1-yl)benzamide, ACETATE ION, Serine/threonine-protein kinase PLK1, ...
Authors:Hosfield, D.J, Skene, R.J.
Deposit date:2013-02-07
Release date:2013-05-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Bioorg.Med.Chem.Lett., 23, 2013
2OU7
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BU of 2ou7 by Molmil
Structure of the Catalytic Domain of Human Polo-like Kinase 1
Descriptor: ACETATE ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ding, Y.-H, Kothe, M, Kohls, D, Low, S.
Deposit date:2007-02-09
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the catalytic domain of human polo-like kinase 1.
Biochemistry, 46, 2007
2OWB
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BU of 2owb by Molmil
Structure of the Catalytic Domain of Human Polo-like Kinase 1
Descriptor: 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE, ACETATE ION, Serine/threonine-protein kinase PLK1, ...
Authors:Ding, Y.-H, Kothe, M, Kohls, D, Low, S.
Deposit date:2007-02-15
Release date:2007-04-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the catalytic domain of human polo-like kinase 1.
Biochemistry, 46, 2007
2RKU
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BU of 2rku by Molmil
Structure of PLK1 in complex with BI2536
Descriptor: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, D(-)-TARTARIC ACID, L(+)-TARTARIC ACID, ...
Authors:Ding, Y.-H, Kothe, M, Kohls, D, Low, S.
Deposit date:2007-10-17
Release date:2008-02-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Selectivity-determining residues in Plk1.
Chem.Biol.Drug Des., 70, 2007
5NMM
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BU of 5nmm by Molmil
The structure of the polo-box domain (PBD) of Plk1 in complex with Alpha-Bromo-3-Iodotoluene.
Descriptor: Alpha-Bromo-3-Iodotoluene, Serine/threonine-protein kinase PLK1
Authors:Kunciw, D.L, Rossmann, M, Stokes, J.E, De Fusco, C, Spring, D.R, Hyvonen, M.
Deposit date:2017-04-06
Release date:2018-02-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
Sci Rep, 9, 2019
5NEI
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BU of 5nei by Molmil
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with JES107
Descriptor: 2-[[3-[[5-(3-iodanylphenyl)carbonylthiophen-2-yl]carbonylamino]phenyl]methyl]propanedioic acid, Serine/threonine-protein kinase PLK1
Authors:Kunciw, D.L, Rossmann, M, Stokes, J.E, De Fusco, C, Spring, D.R, Hyvonen, M.
Deposit date:2017-03-10
Release date:2018-02-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:A fragment-based approach to developing inhibitors of the cryptic pocket of the Polo-Like Kinase 1 Polo-Box Domain.
To Be Published
5NN2
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BU of 5nn2 by Molmil
The structure of the polo-box domain (PBD) of Plk1 in complex with Z228588490
Descriptor: (3~{R},5~{R})-1-[2,4-bis(fluoranyl)phenyl]-5-oxidanyl-pyrrolidine-3-carboxylic acid, Serine/threonine-protein kinase PLK1
Authors:Kunciw, D.L, Rossmann, M, Stokes, J.E, De Fusco, C, Spring, D.R, Hyvonen, M.
Deposit date:2017-04-07
Release date:2018-02-21
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A fragment-based approach to developing inhibitors of the cryptic pocket of the Polo-Like Kinase 1 Polo-Box Domain.
To Be Published
5NJE
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BU of 5nje by Molmil
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with Alpha-Bromo-3-Iodotoluene.
Descriptor: Alpha-Bromo-3-Iodotoluene, Serine/threonine-protein kinase PLK1
Authors:Kunciw, D.L, Rossmann, M, Stokes, J.E, De Fusco, C, Spring, D.R, Hyvonen, M.
Deposit date:2017-03-28
Release date:2018-05-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.978 Å)
Cite:A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
Sci Rep, 9, 2019
5NN1
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BU of 5nn1 by Molmil
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1)
Descriptor: Serine/threonine-protein kinase PLK1
Authors:Kunciw, D.L, Rossmann, M, De Fusco, C, Spring, D.R, Hyvonen, M.
Deposit date:2017-04-07
Release date:2018-02-21
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.785 Å)
Cite:Developing peptidic inhibitors of the cryptic pocket of the Polo-Like Kinase 1 Polo-Box Domain.
To Be Published
5NFU
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BU of 5nfu by Molmil
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LHSpTA peptide
Descriptor: Ac-LEU-HIS-SER-(TPO)-ALA, Serine/threonine-protein kinase PLK1
Authors:Kunciw, D.L, Rossmann, M, De Fusco, C, Spring, D.R, Hyvonen, M.
Deposit date:2017-03-16
Release date:2018-05-16
Last modified:2023-03-08
Method:X-RAY DIFFRACTION (1.809 Å)
Cite:A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
Sci Rep, 9, 2019
3P2W
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BU of 3p2w by Molmil
Unliganded form of Polo-like kinase I Polo-box domain
Descriptor: GLYCEROL, SULFATE ION, Serine/threonine-protein kinase PLK1
Authors:Sledz, P, Hyvonen, M, Abell, C.
Deposit date:2010-10-04
Release date:2011-04-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Angew.Chem.Int.Ed.Engl., 50, 2011
3P34
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BU of 3p34 by Molmil
Polo-like kinase I Polo-box domain in complex with MQSpTPL phosphopeptide
Descriptor: GLYCEROL, SULFATE ION, Serine/threonine-protein kinase PLK1, ...
Authors:Sledz, P, Hyvonen, M, Abell, C.
Deposit date:2010-10-04
Release date:2011-04-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Angew.Chem.Int.Ed.Engl., 50, 2011

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