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PDB: 74 results

4WHL
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A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Descriptor: C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR, Serine/threonine-protein kinase PLK1
Authors:Bang, J.K, Han, Y.H, Ahn, M.J, Lee, K.S.
Deposit date:2014-09-23
Release date:2014-12-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
J.Med.Chem., 58, 2015
4WHH
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BU of 4whh by Molmil
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Descriptor: C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR, SULFATE ION, Serine/threonine-protein kinase PLK1
Authors:Bang, J.K.
Deposit date:2014-09-22
Release date:2014-12-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
J.Med.Chem., 58, 2015
3HIH
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BU of 3hih by Molmil
Structure of human Plk1-PBD with glycerol and sulfate in the phophopeptide binding site
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ...
Authors:Wlodawer, A, Moulaei, T.
Deposit date:2009-05-20
Release date:2009-06-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nat.Struct.Mol.Biol., 16, 2009
3HIK
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Structure of human Plk1-PBD in complex with PLHSpT
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Pentamer phosphopeptide, ...
Authors:Wlodawer, A, Moulaei, T.
Deposit date:2009-05-20
Release date:2009-06-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nat.Struct.Mol.Biol., 16, 2009
3RQ7
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BU of 3rq7 by Molmil
Polo-like kinase 1 Polo box domain in complex with a C6H5(CH2)8-derivatized peptide inhibitor
Descriptor: C6H5(CH2)8-derivatized peptide inhibitor, Serine/threonine-protein kinase PLK1
Authors:Liu, F, Park, J.-E, Qian, W.-J, Lim, D.C, Graber, M, Berg, T, Yaffe, M.B, Lee, K.S, Burke Jr, T.R.
Deposit date:2011-04-27
Release date:2011-07-20
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
Nat.Chem.Biol., 7, 2011
3THB
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Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor
Descriptor: 9-chloro-2-({5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thi one, Serine/threonine-protein kinase PLK1, ZINC ION
Authors:Sintchak, M.D.
Deposit date:2011-08-18
Release date:2011-11-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905).
J.Med.Chem., 55, 2012
3KB7
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Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor
Descriptor: 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide, L(+)-TARTARIC ACID, Serine/threonine-protein kinase PLK1, ...
Authors:Bossi, R.T, Bertrand, J.A.
Deposit date:2009-10-20
Release date:2010-05-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors
J.Med.Chem., 53, 2010
4J53
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Crystal structure of PLK1 in complex with TAK-960
Descriptor: 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide, ACETATE ION, Serine/threonine-protein kinase PLK1, ...
Authors:Hosfield, D.J, Skene, R.J.
Deposit date:2013-02-07
Release date:2013-05-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Bioorg.Med.Chem.Lett., 23, 2013
4O6W
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Peptide-Based Inhibitors of Plk1 Polo-box Domain
Descriptor: Peptide-Based inhibitor, Serine/threonine-protein kinase PLK1
Authors:Qian, W.-J, Park, J.-E, Lim, D.C, Park, S.-Y, Lee, K.-W, Yaffe, M.B, Lee, K.S, Burke, T.R.
Deposit date:2013-12-23
Release date:2014-12-03
Method:X-RAY DIFFRACTION (1.448 Å)
Cite:Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells.
Biopolymers, 102, 2014
4LKM
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Crystal structure of Plk1 Polo-box domain in complex with PL-74
Descriptor: GLYCEROL, PL-74, SULFATE ION, ...
Authors:Lee, W.C, Song, J.H, Kim, H.Y.
Deposit date:2013-07-08
Release date:2013-12-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1
Plos One, 8, 2013
4LKL
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Crystal structure of Plk1 Polo-box domain in complex with PL-55
Descriptor: ADAMANTANE, PL-55, Serine/threonine-protein kinase PLK1
Authors:Lee, W.C, Song, J.H, Kim, H.Y.
Deposit date:2013-07-08
Release date:2013-12-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1
Plos One, 8, 2013
2OGQ
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Molecular and structural basis of Plk1 substrate recognition: Implications in centrosomal localization
Descriptor: Serine/threonine-protein kinase PLK1
Authors:Garcia-Alvarez, B, de Carcer, G, Ibanez, S, Bragado-Nilsson, E, Montoya, G.
Deposit date:2007-01-08
Release date:2007-02-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.
Proc.Natl.Acad.Sci.Usa, 104, 2007
4DFW
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Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
Descriptor: CHLORIDE ION, Peptide, Serine/threonine-protein kinase PLK1
Authors:Liu, F, Park, J.-E, Qian, W.-J, Lim, D, Gr ber, M, Berg, T, Yaffe, M.B, Lee, K.S, Burke Jr, T.R.
Deposit date:2012-01-24
Release date:2012-03-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
Chem.Biol., 2012
4O56
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Structure of PLK1 in complex with peptide
Descriptor: PHOSPHATE ION, Serine/threonine-protein kinase PLK1, synthetic peptide
Authors:Wang, T.
Deposit date:2013-12-19
Release date:2014-12-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Integration of Charge-dipole Interaction and Intramolecular Hydrogen Bond in Ligand Design for the Polo-Box Domain of Polo-like Kinase 1
To be Published
4O9W
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BU of 4o9w by Molmil
Crystal structure of polo-like kinase(PLK1)PBD in complex with phospho peptide
Descriptor: Serine/threonine-protein kinase PLK1, phospho peptide VAL-LEU-SER-TPO-LEU-NH2
Authors:Bong, S.M, Lee, B.I, Kim, K.T.
Deposit date:2014-01-03
Release date:2014-08-13
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.694 Å)
Cite:The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores.
Nat Commun, 5, 2014
2OU7
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Structure of the Catalytic Domain of Human Polo-like Kinase 1
Descriptor: ACETATE ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ding, Y.-H, Kothe, M, Kohls, D, Low, S.
Deposit date:2007-02-09
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the catalytic domain of human polo-like kinase 1.
Biochemistry, 46, 2007
2OWB
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BU of 2owb by Molmil
Structure of the Catalytic Domain of Human Polo-like Kinase 1
Descriptor: 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE, ACETATE ION, Serine/threonine-protein kinase PLK1, ...
Authors:Ding, Y.-H, Kothe, M, Kohls, D, Low, S.
Deposit date:2007-02-15
Release date:2007-04-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the catalytic domain of human polo-like kinase 1.
Biochemistry, 46, 2007
4E9D
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BU of 4e9d by Molmil
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide
Descriptor: 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide, GLYCEROL, Serine/threonine-protein kinase PLK1
Authors:Sledz, P, Hyvonen, M, Lang, S, Stubbs, C.J, Abell, C.
Deposit date:2012-03-21
Release date:2012-10-10
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
Angew.Chem.Int.Ed.Engl., 51, 2012
4J52
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BU of 4j52 by Molmil
Crystal structure of PLK1 in complex with a pyrimidodiazepinone inhibitor
Descriptor: 4-{[(7R)-9-cyclopentyl-7-ethenyl-7-fluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl]amino}-3-methoxy-N-(4-methylpiperazin-1-yl)benzamide, ACETATE ION, Serine/threonine-protein kinase PLK1, ...
Authors:Hosfield, D.J, Skene, R.J.
Deposit date:2013-02-07
Release date:2013-05-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Bioorg.Med.Chem.Lett., 23, 2013
4E67
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BU of 4e67 by Molmil
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide
Descriptor: Serine/threonine-protein kinase PLK1, hydrocinnamoyl-derivatized PLHSpTA peptide
Authors:Sledz, P, Hyvonen, M, Tan, Y.S, Lang, S, Spring, D, Abell, C, Best, R.B.
Deposit date:2012-03-15
Release date:2012-10-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.
Angew.Chem.Int.Ed.Engl., 51, 2012
4E9C
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The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LDPPLHSpTA phosphopeptide
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, GLYCEROL, LDPPLHSpTA phosphopeptide, ...
Authors:Sledz, P, Hyvonen, M, Lang, S, Stubbs, C.J, Abell, C.
Deposit date:2012-03-21
Release date:2012-10-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
Angew. Chem. Int. Ed. Engl., 51, 2012
4RCP
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BU of 4rcp by Molmil
Crystal structure of Plk1 Polo-box domain in complex with PL-2
Descriptor: 1,2-ETHANEDIOL, PL-2, Serine/threonine-protein kinase PLK1
Authors:Lee, W.C, Song, J.H, Kim, H.Y.
Deposit date:2014-09-16
Release date:2014-11-12
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
J.Med.Chem., 58, 2015
4HCO
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BU of 4hco by Molmil
Human Plk1-PBD in complex with Thymoquinone at the phophopeptide binding site
Descriptor: 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione, GLYCEROL, Serine/threonine-protein kinase PLK1
Authors:Yin, Z, Rehse, P.H.
Deposit date:2012-10-01
Release date:2012-10-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
Acs Chem.Biol., 8, 2013
4HAB
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BU of 4hab by Molmil
Crystal structure of Plk1 Polo-box domain in complex with PL-49
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, PHOSPHATE ION, PL-49, ...
Authors:Lee, W.C, Song, J.H, Kim, H.Y.
Deposit date:2012-09-26
Release date:2013-04-03
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
Bioorg.Med.Chem., 21, 2013
4H5X
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BU of 4h5x by Molmil
human Plk1-PBD with a glycerol bound at the phophopeptide binding site
Descriptor: GLYCEROL, Serine/threonine-protein kinase PLK1
Authors:Yin, Z, Rehse, P.H.
Deposit date:2012-09-19
Release date:2012-10-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
Acs Chem.Biol., 8, 2013

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