5NEI

The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with JES107

Summary for 5NEI

• Entry DOI: 10.2210/pdb5nei/pdb
• Descriptor: Serine/threonine-protein kinase PLK1, 2-[[3-[[5-(3-iodanylphenyl)carbonylthiophen-2-yl]carbonylamino]phenyl]methyl]propanedioic acid (3 entities in total)
• Functional Keywords: plk1, pbd1, mitosis, small molecule, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: P53350
• Total number of polymer chains: 1
• Total formula weight: 27834.49

Authors

Kunciw, D.L.,Rossmann, M.,Stokes, J.E.,De Fusco, C.,Spring, D.R.,Hyvonen, M. (deposition date: 2017-03-10, release date: 2018-02-21, Last modification date: 2024-02-07)

• Primary citation: Kunciw, D.L.,De Fusco, C.,Rossmann, M.,Stokes, J.E.,Renzetti, A.,Sore, H.F.,Hyvonen, M.,Spring, D.R.; A fragment-based approach to developing inhibitors of the cryptic pocket of the Polo-Like Kinase 1 Polo-Box Domain.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.68 Å)