5NFU

The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LHSpTA peptide

Summary for 5NFU

Entry DOI	10.2210/pdb5nfu/pdb
Descriptor	Serine/threonine-protein kinase PLK1, Ac-LEU-HIS-SER-(TPO)-ALA (3 entities in total)
Functional Keywords	plk1, pbd1, mitosis, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	27848.68
Authors	Kunciw, D.L.,Rossmann, M.,De Fusco, C.,Spring, D.R.,Hyvonen, M. (deposition date: 2017-03-16, release date: 2018-05-16, Last modification date: 2023-03-08)
Primary citation	Sharma, P.,Mahen, R.,Rossmann, M.,Stokes, J.E.,Hardwick, B.,Huggins, D.J.,Emery, A.,Kunciw, D.L.,Hyvonen, M.,Spring, D.R.,McKenzie, G.J.,Venkitaraman, A.R. A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation. Sci Rep, 9:15930-15930, 2019 Cited by PubMed: 31685831 DOI: 10.1038/s41598-019-50702-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.809 Å)

Structure validation