4WHK
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Summary for 4WHK
Entry DOI | 10.2210/pdb4whk/pdb |
Related | 4WHH 4WHL |
Related PRD ID | PRD_002118 |
Descriptor | Serine/threonine-protein kinase PLK1, C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR (3 entities in total) |
Functional Keywords | polo-like kinase, inhibitor, peptide derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: P53350 |
Total number of polymer chains | 2 |
Total formula weight | 28081.00 |
Authors | Bang, J.K.,Han, Y.H.,Ahn, M.J.,Lee, K.S. (deposition date: 2014-09-23, release date: 2014-12-03, Last modification date: 2023-11-15) |
Primary citation | Ahn, M.,Han, Y.H.,Park, J.E.,Kim, S.,Lee, W.C.,Lee, S.J.,Gunasekaran, P.,Cheong, C.,Shin, S.Y.,Kim, H.Y.,Ryu, E.K.,Murugan, R.N.,Kim, N.H.,Bang, J.K. A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1. J.Med.Chem., 58:294-304, 2015 Cited by PubMed: 25347203DOI: 10.1021/jm501147g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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