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PDB: 1657 results

7UJU
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Room-temperature X-ray structure of monomeric SARS-CoV-2 main protease catalytic domain (MPro1-196) in complex with nirmatrelvir
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Kovalevsky, A, Kneller, D.W, Coates, L.
Deposit date:2022-03-31
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain.
Commun Biol, 5, 2022
7UJ9
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Room-temperature X-ray structure of monomeric SARS-CoV-2 main protease catalytic domain (MPro1-199)
Descriptor: 3C-like proteinase nsp5
Authors:Kovalevsky, A, Kneller, D.W, Coates, L.
Deposit date:2022-03-30
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain.
Commun Biol, 5, 2022
7UJG
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Room-temperature X-ray structure of monomeric SARS-CoV-2 main protease catalytic domain (MPro1-196) in complex with GC-376
Descriptor: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5
Authors:Kovalevsky, A, Kneller, D.W, Coates, L.
Deposit date:2022-03-30
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain.
Commun Biol, 5, 2022
7WQI
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Crystal structure of SARS coronavirus main protease in complex with PF07304814
Descriptor: 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate
Authors:Lin, C, Zhong, F.L, Zhou, X.L, Zeng, P, Zhang, J, Li, J.
Deposit date:2022-01-25
Release date:2023-01-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal structure of SARS coronavirus main protease in complex with PF07304814
To Be Published
7WQA
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SARS-CoV-2 main protease in complex with Z-VAD-FMK
Descriptor: 3C-like proteinase, Z-VAD(OMe)-FMK
Authors:Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chen, Y.
Deposit date:2022-01-25
Release date:2023-03-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:SARS-CoV-2 main protease in complex with Z-VAD-FMK
To Be Published
7WQ9
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Crystal structure of SARS-CoV-2 main protease in complex with Z-IETD-FMK
Descriptor: 3C-like proteinase, Z-IETD-FMK
Authors:Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chen, Y.
Deposit date:2022-01-25
Release date:2023-08-02
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:Crystal structure of SARS-CoV-2 main protease in complex with Z-IETD-FMK
To Be Published
7WQ8
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Crystal structure of SARS-CoV-2 main protease in complex with Z-DEVD-FMK
Descriptor: 3C-like proteinase, Z-DEVD-FMK
Authors:Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chen, Y.
Deposit date:2022-01-24
Release date:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of SARS-CoV-2 main protease in complex with Z-DEVD-FMK
To Be Published
7WQK
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wild-type SARS-CoV-2 main protease in complex with MG-132
Descriptor: 3C-like proteinase, MAGNESIUM ION, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide
Authors:Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chen, Y.
Deposit date:2022-01-25
Release date:2023-08-02
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:wild-type SARS-CoV-2 main protease in complex with MG-132
To Be Published
7WQB
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SARS-CoV-2 main protease mutant (P168A) in complex with MG-132
Descriptor: 3C-like proteinase nsp5, MAGNESIUM ION, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide
Authors:Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chen, Y.
Deposit date:2022-01-25
Release date:2023-08-02
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:SARS-CoV-2 main protease mutant (P168A) in complex with MG-132
To Be Published
7WYM
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Structure of the SARS-COV-2 main protease with 337 inhibitor
Descriptor: 3C-like proteinase nsp5, N-methyl-N-[[4-(trifluoromethyl)-1,3-thiazol-2-yl]methyl]prop-2-enamide
Authors:Qin, B, Hou, P, Gao, X, Cui, S.
Deposit date:2022-02-16
Release date:2022-06-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.
Acta Pharm Sin B, 12, 2022
7WYP
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Structure of the SARS-COV-2 main protease with EN102 inhibitor
Descriptor: 3C-like proteinase, N-(1,3-benzothiazol-2-ylmethyl)-N-cyclopropyl-prop-2-enamide
Authors:Qin, B, Hou, P, Gao, X, Cui, S.
Deposit date:2022-02-16
Release date:2022-06-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.
Acta Pharm Sin B, 12, 2022
7X6K
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BU of 7x6k by Molmil
SARS-CoV-2 3CL protease (3CLpro) in complex with compound 3w
Descriptor: 1H-indole-2-carbaldehyde, 3C-like proteinase
Authors:Su, H, Nie, T, Xie, H, Li, Z.W, Li, M.J, Xu, Y.
Deposit date:2022-03-07
Release date:2022-07-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination.
J.Med.Chem., 65, 2022
7X6J
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SARS-CoV-2 3CL protease (3CLpro) in complex with compound 3af
Descriptor: 3C-like proteinase, quinoline-2-carboxylic acid
Authors:Su, H, Nie, T, Xie, H, Li, Z.W, Li, M.J, Xu, Y.
Deposit date:2022-03-07
Release date:2022-07-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination.
J.Med.Chem., 65, 2022
7BIJ
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BU of 7bij by Molmil
Crystal Structure of SARS-CoV-2 main protease (Nsp5) in complex with compound 13
Descriptor: (3~{S})-3'-(5-fluoranylpyridin-3-yl)spiro[1,2-dihydroindene-3,5'-imidazolidine]-2',4'-dione, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE
Authors:Talibov, V.O.
Deposit date:2021-01-12
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
J.Am.Chem.Soc., 144, 2022
7C2Y
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BU of 7c2y by Molmil
The crystal structure of COVID-2019 main protease in the apo state
Descriptor: 3C-like proteinase
Authors:Zhou, X.L, Zhong, F.L, Lin, C, Zhou, H, Hu, X.H, Wang, Q.S, Li, J, Zhang, J.
Deposit date:2020-05-10
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:COVID-2019 main protease in the apo state
To Be Published
7C6S
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Crystal structure of the SARS-CoV-2 main protease complexed with Boceprevir
Descriptor: 3C-like proteinase, boceprevir (bound form)
Authors:Fu, L, Feng, Y.
Deposit date:2020-05-22
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.
Nat Commun, 11, 2020
7CBT
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The crystal structure of SARS-CoV-2 main protease in complex with GC376
Descriptor: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase
Authors:Shi, Y, Peng, G.
Deposit date:2020-06-13
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.346 Å)
Cite:The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract.
Emerg Microbes Infect, 10, 2021
7C7P
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Crystal structure of the SARS-CoV-2 main protease in complex with Telaprevir
Descriptor: (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide, 3C-like proteinase, CHLORIDE ION
Authors:Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Yang, S.Y, Lei, J.
Deposit date:2020-05-26
Release date:2020-07-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model.
Science, 371, 2021
7C2Q
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BU of 7c2q by Molmil
The crystal structure of COVID-19 main protease in the apo state
Descriptor: 3C-like proteinase
Authors:Zhou, X.L, Zhong, F.L, Lin, C, Hu, X.H, Zhou, H, Wang, Q.S, Li, j, Zhang, J.
Deposit date:2020-05-08
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structure of SARS-CoV-2 main protease in the apo state.
Sci China Life Sci, 64, 2021
7C6U
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BU of 7c6u by Molmil
Crystal structure of SARS-CoV-2 complexed with GC376
Descriptor: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase
Authors:Fu, L, Feng, Y, Qi, J, Gao, F.G.
Deposit date:2020-05-22
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.
Nat Commun, 11, 2020
7COM
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BU of 7com by Molmil
Crystal structure of the SARS-CoV-2 main protease in complex with Boceprevir (space group P212121)
Descriptor: 3C-like proteinase, boceprevir (bound form)
Authors:Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Liu, J.M, Zhou, Y.L, Chen, P, Yang, S.Y, Lei, J.
Deposit date:2020-08-04
Release date:2020-08-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model.
Science, 371, 2021
7C8U
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The crystal structure of COVID-19 main protease in complex with GC376
Descriptor: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase
Authors:Luan, X, Shang, W, Wang, Y, Yin, W, Jiang, Y, Feng, S, Wang, Y, Liu, M, Zhou, R, Zhang, Z, Wang, F, Cheng, W, Gao, M, Wang, H, Wu, W, Tian, R, Tian, Z, Jin, Y, Jiang, H.W, Zhang, L, Xu, H.E, Zhang, S.
Deposit date:2020-06-03
Release date:2020-06-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The crystal structure of COVID-19 main protease in complex with GC376
To Be Published
7CWC
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Ambient-Temperature Serial Femtosecond X-ray Crystal structure of SARS-CoV-2 Main Protease at 2.1 A Resolution (P212121)
Descriptor: 3C-like proteinase
Authors:DeMirci, H.
Deposit date:2020-08-27
Release date:2020-09-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing.
Structure, 29, 2021
7C8B
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Crystal structure of the SARS-CoV-2 main protease in complex with Z-VAD(OMe)-FMK
Descriptor: 3C-like proteinase, CHLORIDE ION, Z-VAD(OMe)-FMK
Authors:Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Yang, S.Y, Lei, J.
Deposit date:2020-05-29
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the SARS-CoV-2 main protease in complex with Z-VAD(OMe)-FMK
To Be Published
7C8T
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Complex Structure of SARS-CoV-2 3CL Protease with TG-0205221
Descriptor: 3C-like proteinase, N-[(BENZYLOXY)CARBONYL]-O-(TERT-BUTYL)-L-THREONYL-3-CYCLOHEXYL-N-[(1S)-2-HYDROXY-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}ETHYL]-L-ALANINAMIDE
Authors:Lee, C.C, Wang, A.H.J, Kuo, C.J, Liang, P.H.
Deposit date:2020-06-03
Release date:2020-06-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Complex Structures and Cellular Activities of the Potent SARS-CoV-2 3CLpro Inhibitors Guiding Drug Discovery Against COVID-19
To Be Published

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PDB entries from 2024-06-26

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