7C6U
Crystal structure of SARS-CoV-2 complexed with GC376
Summary for 7C6U
Entry DOI | 10.2210/pdb7c6u/pdb |
Descriptor | 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total) |
Functional Keywords | sars-cov-2, main protease, inhibitor, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 1 |
Total formula weight | 34311.10 |
Authors | |
Primary citation | Fu, L.,Ye, F.,Feng, Y.,Yu, F.,Wang, Q.,Wu, Y.,Zhao, C.,Sun, H.,Huang, B.,Niu, P.,Song, H.,Shi, Y.,Li, X.,Tan, W.,Qi, J.,Gao, G.F. Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun, 11:4417-4417, 2020 Cited by PubMed: 32887884DOI: 10.1038/s41467-020-18233-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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