7CWC

Ambient-Temperature Serial Femtosecond X-ray Crystal structure of SARS-CoV-2 Main Protease at 2.1 A Resolution (P212121)

Summary for 7CWC

• Entry DOI: 10.2210/pdb7cwc/pdb
• Related: 7WCB
• Descriptor: 3C-like proteinase (2 entities in total)
• Functional Keywords: covid19, sars-cov-2, drug target, serial femtosecond x-ray crystallography, sfx, xfel, virus protein, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 2
• Total formula weight: 68478.03

Authors

DeMirci, H. (deposition date: 2020-08-27, release date: 2020-09-30, Last modification date: 2023-11-29)

• Primary citation: Durdagi, S.,Dag, C.,Dogan, B.,Yigin, M.,Avsar, T.,Buyukdag, C.,Erol, I.,Ertem, F.B.,Calis, S.,Yildirim, G.,Orhan, M.D.,Guven, O.,Aksoydan, B.,Destan, E.,Sahin, K.,Besler, S.O.,Oktay, L.,Shafiei, A.,Tolu, I.,Ayan, E.,Yuksel, B.,Peksen, A.B.,Gocenler, O.,Yucel, A.D.,Can, O.,Ozabrahamyan, S.,Olkan, A.,Erdemoglu, E.,Aksit, F.,Tanisali, G.,Yefanov, O.M.,Barty, A.,Tolstikova, A.,Ketawala, G.K.,Botha, S.,Dao, E.H.,Hayes, B.,Liang, M.,Seaberg, M.H.,Hunter, M.S.,Batyuk, A.,Mariani, V.,Su, Z.,Poitevin, F.,Yoon, C.H.,Kupitz, C.,Sierra, R.G.,Snell, E.H.,DeMirci, H.; Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing.; Structure, 29:1382-1396.e6, 2021; PubMed: 34403647; DOI: 10.1016/j.str.2021.07.007

Experimental method

X-RAY DIFFRACTION (2.1 Å)