2HEK
 
 | | Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution. | | Descriptor: | BROMIDE ION, CHLORIDE ION, GLYCEROL, ... | | Authors: | Oganesyan, V, Jancarik, J, Adams, P.D, Kim, R, Kim, S.H, Berkeley Structural Genomics Center (BSGC) | | Deposit date: | 2006-06-21 | | Release date: | 2006-07-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.997 Å) | | Cite: | Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus.
Acta Crystallogr.,Sect.F, 63, 2007
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4UW2
 | | Crystal structure of Csm1 in T.onnurineus | | Descriptor: | CSM1 | | Authors: | Jung, T.Y, An, Y, Park, K.H, Lee, M.H, Oh, B.H, Woo, E.J. | | Deposit date: | 2014-08-08 | | Release date: | 2015-03-25 | | Last modified: | 2015-09-23 | | Method: | X-RAY DIFFRACTION (2.632 Å) | | Cite: | Crystal Structure of the Csm1 Subunit of the Csm Complex and its Single-Stranded DNA-Specific Nuclease Activity.
Structure, 23, 2015
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1VJ7
 | | Crystal structure of the bifunctional catalytic fragment of RelSeq, the RelA/SpoT homolog from Streptococcus equisimilis. | | Descriptor: | Bifunctional RELA/SPOT, GUANOSINE 5'-DIPHOSPHATE 2':3'-CYCLIC MONOPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Hogg, T, Mechold, U, Malke, H, Cashel, M, Hilgenfeld, R. | | Deposit date: | 2004-02-03 | | Release date: | 2004-05-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response.
Cell(Cambridge,Mass.), 117, 2004
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8D94
 | | SAMHD1-DNA complex | | Descriptor: | CALCIUM ION, DNA (5'-D(P*TP*GP*T)-3'), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | | Authors: | Hollis, T.J, Batalis, S.M. | | Deposit date: | 2022-06-09 | | Release date: | 2023-07-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | SAMHD1-DNA complex
To Be Published
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8D9J
 | | SAMHD1-DNA complex | | Descriptor: | CALCIUM ION, DNA (5'-D(*CP*AP*AP*TP*G)-3'), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | | Authors: | Hollis, T.J, Batalis, S.M. | | Deposit date: | 2022-06-10 | | Release date: | 2023-07-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.82 Å) | | Cite: | SAMHD1-DNA complex
To Be Published
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3IRH
 | | Structure of an Enterococcus Faecalis HD-domain protein complexed with dGTP and dATP | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | | Authors: | Vorontsov, I.I, Minasov, G, Shuvalova, L, Brunzelle, J.S, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2009-08-24 | | Release date: | 2009-09-22 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Characterization of the deoxynucleotide triphosphate triphosphohydrolase (dNTPase) activity of the EF1143 protein from Enterococcus faecalis and crystal structure of the activator-substrate complex.
J.Biol.Chem., 286, 2011
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8ACU
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8BMW
 | | SsoCsm | | Descriptor: | CRISPR-associated Cas7 paralog (Type III-D), CRISPR-associated protein Cas10 (Type III-D), CRISPR-associated protein Cas5 (Type III-D), ... | | Authors: | Spagnolo, L, White, M.F. | | Deposit date: | 2022-11-11 | | Release date: | 2023-03-01 | | Last modified: | 2023-03-22 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of the Saccharolobus solfataricus type III-D CRISPR effector.
Curr Res Struct Biol, 5, 2023
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2DQB
 | | Crystal structure of dNTP triphosphohydrolase from Thermus thermophilus HB8, which is homologous to dGTP triphosphohydrolase | | Descriptor: | Deoxyguanosinetriphosphate triphosphohydrolase, putative, MAGNESIUM ION | | Authors: | Kondo, N, Nakagawa, N, Ebihara, A, Chen, L, Liu, Z.-J, Wang, B.-C, Yokoyama, S, Kuramitsu, S, Masui, R, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-05-25 | | Release date: | 2007-01-23 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of dNTP-inducible dNTP triphosphohydrolase: insight into broad specificity for dNTPs and triphosphohydrolase-type hydrolysis
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
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6IQW
 | | Cryo-EM structure of Csm effector complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Csm1, Csm2, ... | | Authors: | Huo, Y, Li, T, Wang, N, Dong, Q, Wang, X, Jiang, T. | | Deposit date: | 2018-11-09 | | Release date: | 2019-01-16 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Cryo-EM structure of Type III-A CRISPR effector complex.
Cell Res., 28, 2018
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4LRL
 | | Structure of an Enterococcus Faecalis HD-domain protein complexed with dGTP and dTTP | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HD domain protein, ... | | Authors: | Vorontsov, I.I, Minasov, G, Shuvalova, L, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2013-07-19 | | Release date: | 2013-11-20 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Mechanisms of Allosteric Activation and Inhibition of the Deoxyribonucleoside Triphosphate Triphosphohydrolase from Enterococcus faecalis.
J.Biol.Chem., 289, 2014
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6KBD
 | | fused To-MtbCsm1 with 2dATP | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A),CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), MAGNESIUM ION | | Authors: | Li, T, Huo, Y, Jiang, T. | | Deposit date: | 2019-06-24 | | Release date: | 2020-06-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Mycobacterium tuberculosis CRISPR/Cas system Csm1 holds clues to the evolutionary relationship between DNA polymerase and cyclase activity.
Int.J.Biol.Macromol., 170, 2020
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6KC0
 | | fused To-MtbCsm1 with 2ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A),CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), MAGNESIUM ION | | Authors: | Li, T, Huo, Y, Jiang, T. | | Deposit date: | 2019-06-26 | | Release date: | 2020-07-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.295 Å) | | Cite: | Mycobacterium tuberculosis CRISPR/Cas system Csm1 holds clues to the evolutionary relationship between DNA polymerase and cyclase activity.
Int.J.Biol.Macromol., 170, 2020
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5AO0
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6XN4
 | | Structure of the Lactococcus lactis Csm CTR_3:2 CRISPR-Cas Complex | | Descriptor: | CRISPR-associated protein Cas10, CRISPR-associated protein Csm2, CRISPR-associated protein Csm3, ... | | Authors: | Rai, J, Sridhara, S, Li, H. | | Deposit date: | 2020-07-02 | | Release date: | 2022-01-12 | | Last modified: | 2022-04-13 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex.
Commun Biol, 5, 2022
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6XN5
 | | Structure of the Lactococcus lactis Csm Apo- CRISPR-Cas Complex | | Descriptor: | CRISPR-associated protein Cas10, CRISPR-associated protein Csm3, CRISPR-associated protein Csm4, ... | | Authors: | Rai, J, Sridhara, S, Li, H. | | Deposit date: | 2020-07-02 | | Release date: | 2022-01-12 | | Last modified: | 2022-04-13 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex.
Commun Biol, 5, 2022
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6XN7
 | | Structure of the Lactococcus lactis Csm NTR CRISPR-Cas Complex | | Descriptor: | CRISPR-associated protein Cas10, CRISPR-associated protein Csm2, CRISPR-associated protein Csm3, ... | | Authors: | Rai, J, Sridhara, S, Li, H. | | Deposit date: | 2020-07-02 | | Release date: | 2022-01-12 | | Last modified: | 2022-04-13 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex.
Commun Biol, 5, 2022
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6XN3
 | | Structure of the Lactococcus lactis Csm CTR_4:3 CRISPR-Cas Complex | | Descriptor: | CRISPR-associated protein Cas10, CRISPR-associated protein Csm2, CRISPR-associated protein Csm3, ... | | Authors: | Rai, J, Sridhara, S, Li, H. | | Deposit date: | 2020-07-02 | | Release date: | 2022-01-12 | | Last modified: | 2022-04-13 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex.
Commun Biol, 5, 2022
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6YXA
 | | Structure of the bifunctional Rel enzyme from B. subtilis | | Descriptor: | GTP pyrophosphokinase, MANGANESE (II) ION | | Authors: | Pausch, P, Bange, G. | | Deposit date: | 2020-04-30 | | Release date: | 2020-09-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.95 Å) | | Cite: | Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel.
Cell Rep, 32, 2020
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6BRK
 | | The SAM domain of mouse SAMHD1 is critical for its activation and regulation | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MAGNESIUM ION | | Authors: | Buzovetsky, O, Tang, C, Knecht, K.M, Antonucci, J.M, Wu, L, Ji, X, Xiong, Y. | | Deposit date: | 2017-11-30 | | Release date: | 2018-02-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | The SAM domain of mouse SAMHD1 is critical for its activation and regulation.
Nat Commun, 9, 2018
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8TDW
 | | ssRNA bound SAMHD1 T open | | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*C)-3'), ... | | Authors: | Sung, M, Huynh, K, Han, S. | | Deposit date: | 2023-07-05 | | Release date: | 2023-11-22 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.
Nucleic Acids Res., 51, 2023
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8TDV
 | | ssRNA bound SAMHD1 T closed | | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Sung, M, Huynh, K, Han, S. | | Deposit date: | 2023-07-05 | | Release date: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.
Nucleic Acids Res., 51, 2023
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8QXM
 | | Cryo-EM structure of tetrameric human SAMHD1 State III - Relaxed | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | | Authors: | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | | Deposit date: | 2023-10-24 | | Release date: | 2024-05-15 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.
Nat Commun, 15, 2024
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6BRH
 | | The SAM domain of mouse SAMHD1 is critical for its activation and regulation | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MAGNESIUM ION | | Authors: | Buzovetsky, O, Tang, C, Knecht, K.M, Antonucci, J.M, Wu, L, Ji, X, Xiong, Y. | | Deposit date: | 2017-11-30 | | Release date: | 2018-02-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | The SAM domain of mouse SAMHD1 is critical for its activation and regulation.
Nat Commun, 9, 2018
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6BRG
 | | The SAM domain of mouse SAMHD1 is critical for its activation and regulation | | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MAGNESIUM ION | | Authors: | Buzovetsky, O, Tang, C, Knecht, K.M, Antonucci, J.M, Wu, L, Ji, X, Xiong, Y. | | Deposit date: | 2017-11-30 | | Release date: | 2018-02-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | The SAM domain of mouse SAMHD1 is critical for its activation and regulation.
Nat Commun, 9, 2018
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