6BRK

The SAM domain of mouse SAMHD1 is critical for its activation and regulation

Summary for 6BRK

Entry DOI	10.2210/pdb6brk/pdb
Related	6BRG 6BRH
Descriptor	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION (3 entities in total)
Functional Keywords	dntpase, allosteric regulation, binding sites, mouse, models, molecular, protein conformation, protein multimerization, hydrolase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	79110.69
Authors	Buzovetsky, O.,Tang, C.,Knecht, K.M.,Antonucci, J.M.,Wu, L.,Ji, X.,Xiong, Y. (deposition date: 2017-11-30, release date: 2018-02-14, Last modification date: 2023-10-04)
Primary citation	Buzovetsky, O.,Tang, C.,Knecht, K.M.,Antonucci, J.M.,Wu, L.,Ji, X.,Xiong, Y. The SAM domain of mouse SAMHD1 is critical for its activation and regulation. Nat Commun, 9:411-411, 2018 Cited by PubMed: 29379009 DOI: 10.1038/s41467-017-02783-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation