6BRK

The SAM domain of mouse SAMHD1 is critical for its activation and regulation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	polymer	672	77564.8	1	UniProt (F8WJE0) Pfam (PF07647) Pfam (PF01966) UniProt (by SIFTS) (Q60710)	Mus musculus (Mouse)
2	B, C, E (A)	2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	3	Chemie (DGT)
3	D (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

A: 1 - 658 (UniProt: F8WJE0)

PDB	External Database	Details
Met -13	-	initiating methionine
Gly -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Leu 0	-	expression tag
Arg 238	His 238	conflict
Asn 239	Asp 239	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	77564.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1545.8
All*	Total formula weight	79110.7

*Water molecules are not included.