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PDB: 792 件
5Z2T
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Crystal structure of DNA-bound DUX4-HD2
分子名称: 5'-D(*TP*TP*CP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*TP*T)-3', 5'-D(P*AP*AP*GP*AP*TP*TP*AP*GP*AP*TP*TP*AP*GP*T)-3', Double homeobox protein 4
著者Dong, X, Zhang, W, Wu, H, Huang, J, Zhang, M, Wang, P, Zhang, H, Chen, Z, Chen, S, Meng, G.
登録日2018-01-04
公開日2018-04-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.623 Å)
主引用文献Structural basis of DUX4/IGH-driven transactivation.
Leukemia, 32, 2018
4S1L
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BU of 4s1l by Molmil
Structure of Uranotaenia sapphirina cypovirus (CPV17) polyhedrin at 298 K
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, polyhedrin
著者Ginn, H.M, Messerschmidt, M, Ji, X, Zhang, H, Axford, D, Gildea, R.J, Winter, G, Brewster, A.S, Hattne, J, Wagner, A, Grimes, J.M, Evans, G, Sauter, N.K, Sutton, G, Stuart, D.I.
登録日2015-01-14
公開日2015-03-25
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.752 Å)
主引用文献Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data.
Nat Commun, 6, 2015
6DCV
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Crystal structure of human anti-tau antibody CBTAU-27.1
分子名称: GLYCEROL, Light chain of CBTAU27.1 Fab, heavy chain of CBTAU-27.1 Fab
著者Zhu, X, Zhang, H, Wilson, I.A.
登録日2018-05-08
公開日2018-06-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
4XAE
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BU of 4xae by Molmil
Structure of Feruloyl-CoA 6-hydroxylase (F6H) from Arabidopsis thaliana
分子名称: Feruloyl CoA ortho-hydroxylase 1, SODIUM ION
著者Zhou, D, Kandavelu, P, Zhang, H, Wang, B.C, Rose, J, Yan, Y.
登録日2014-12-14
公開日2015-06-10
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.769 Å)
主引用文献Structural Insights into Substrate Specificity of Feruloyl-CoA 6'-Hydroxylase from Arabidopsis thaliana.
Sci Rep, 5, 2015
7MYN
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BU of 7myn by Molmil
Cryo-EM Structure of p110alpha in complex with p85alpha
分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Liu, X, Yang, S, Hart, J.R, Xu, Y, Zou, X, Zhang, H, Zhou, Q, Xia, T, Zhang, Y, Yang, D, Wang, M.-W, Vogt, P.K.
登録日2021-05-21
公開日2021-11-10
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.79 Å)
主引用文献Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MYO
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Cryo-EM structure of p110alpha in complex with p85alpha inhibited by BYL-719
分子名称: (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Liu, X, Yang, S, Hart, J.R, Xu, Y, Zou, X, Zhang, H, Zhou, Q, Xia, T, Zhang, Y, Yang, D, Wang, M.-W, Vogt, P.K.
登録日2021-05-21
公開日2021-11-10
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
2KEB
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BU of 2keb by Molmil
NMR solution structure of the N-terminal domain of the DNA polymerase alpha p68 subunit
分子名称: DNA polymerase subunit alpha B
著者Huang, H, Weiner, B.E, Zhang, H, Fuller, B.E, Gao, Y, Wile, B.M, Chazin, W.J, Fanning, E.
登録日2009-01-28
公開日2010-02-02
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome.
J.Biol.Chem., 285, 2010
3Q6B
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The high-resolution and new form crystal structure of BamA POTRA4-5 from E.coli
分子名称: Outer membrane protein assembly complex, YaeT protein
著者Gao, Z.Q, Zhang, H, Dong, Y.H.
登録日2010-12-31
公開日2011-08-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献High-resolution structure of a new crystal form of BamA POTRA4-5 from Escherichia coli.
Acta Crystallogr.,Sect.F, 67, 2011
3Q5Y
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V beta/V beta homodimerization-based pre-TCR model suggested by TCR beta crystal structures
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Chen, Q, Zhang, H, Wang, J.-H.
登録日2010-12-30
公開日2011-03-09
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A conserved hydrophobic patch on Vbeta domains revealed by TCRbeta chain crystal structures: implications for pre-TCR dimerization
Front Immunol, 2, 2011
3MMX
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BU of 3mmx by Molmil
Bacillus anthracis NadD (baNadD) in complex with compound 1_02_3
分子名称: CITRIC ACID, DIMETHYL SULFOXIDE, POTASSIUM ION, ...
著者Huang, N, Zhang, H.
登録日2010-04-20
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.552 Å)
主引用文献Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement.
J.Med.Chem., 53, 2010
4XQO
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BU of 4xqo by Molmil
Crystal structure of hemagglutinin from Jiangxi-Donghu (2013) H10N8 influenza virus in complex with 6'-SLN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
著者Tzarum, N, Zhang, H, Zhu, X, Wilson, I.A.
登録日2015-01-19
公開日2015-04-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors.
Cell Host Microbe, 17, 2015
4XQ5
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BU of 4xq5 by Molmil
Human-infecting H10N8 influenza virus retains strong preference for avian-type receptors
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
著者Tzarum, N, Zhang, H, Zhu, X, Wilson, I.A.
登録日2015-01-19
公開日2015-04-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.592 Å)
主引用文献A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors.
Cell Host Microbe, 17, 2015
4XQU
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BU of 4xqu by Molmil
Crystal structure of hemagglutinin from Jiangxi-Donghu (2013) H10N8 influenza virus in complex with 3'-SLN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ...
著者Tzarum, N, Zhang, H, Zhu, X, Wilson, I.A.
登録日2015-01-20
公開日2015-04-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors.
Cell Host Microbe, 17, 2015
4KYH
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BU of 4kyh by Molmil
Crystal structure of mouse glyoxalase I complexed with zopolrestat
分子名称: 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, Lactoylglutathione lyase, ZINC ION
著者Zhai, J, Yuan, M, Zhang, L, Chen, Y, Zhang, H, Chen, S, Zhao, Y.
登録日2013-05-29
公開日2013-08-07
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Zopolrestat as a human glyoxalase I inhibitor and its structural basis.
Chemmedchem, 8, 2013
5H25
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BU of 5h25 by Molmil
EED in complex with PRC2 allosteric inhibitor compound 11
分子名称: 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
著者Zhao, K, Zhao, M, Luo, X, Zhang, H.
登録日2016-10-14
公開日2017-01-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
5Z2S
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BU of 5z2s by Molmil
Crystal structure of DUX4-HD2 domain
分子名称: Double homeobox protein 4
著者Dong, X, Zhang, W, Wu, H, Huang, J, Zhang, M, Wang, P, Zhang, H, Chen, Z, Chen, S, Meng, G.
登録日2018-01-03
公開日2018-04-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis of DUX4/IGH-driven transactivation.
Leukemia, 32, 2018
5H24
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EED in complex with PRC2 allosteric inhibitor compound 8
分子名称: 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
著者Zhao, K, Zhao, M, Luo, X, Zhang, H.
登録日2016-10-14
公開日2017-01-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
5GSA
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BU of 5gsa by Molmil
EED in complex with an allosteric PRC2 inhibitor
分子名称: Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, Polycomb protein EED
著者Zhao, K, Zhao, M, Luo, X, Zhang, H.
登録日2016-08-15
公開日2017-02-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Nat. Chem. Biol., 13, 2017
8WZ2
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Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex
分子名称: G-alpha q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Jin, S, Li, X, Xu, Y, Guo, S, Wu, C, Zhang, H, Yuan, Q, Xu, H.E, Xie, X, Jiang, Y.
登録日2023-11-01
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (2.73 Å)
主引用文献Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor.
Cell Discov, 10, 2024
5YIR
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Crystal Structure of AnkB LIR/GABARAP complex
分子名称: Ankyrin-2, Gamma-aminobutyric acid receptor-associated protein, NICKEL (II) ION
著者Li, J, Zhu, R, Chen, K, Zheng, H, Yuan, C, Zhang, H, Wang, C, Zhang, M.
登録日2017-10-06
公開日2018-05-23
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.
Nat. Chem. Biol., 14, 2018
4RVP
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Crystal structure of superoxide dismutase from sedum alfredii
分子名称: ZINC ION, superoxide dismutase
著者Qiu, R, Li, C, Zhai, J, Tang, L, Zhang, H, Yuan, M, Hu, X.
登録日2014-11-27
公開日2015-12-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The positive effects of Cd and Cd-Zn relationship in the Zn-related physiological processes involved in growth in the Zn/Cd hyperaccumulator Sedum alfredii
To be Published
3PJA
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BU of 3pja by Molmil
Crystal structure of human C3PO complex
分子名称: Translin, Translin-associated protein X
著者Huang, N, Zhang, H.
登録日2010-11-09
公開日2011-05-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of C3PO and mechanism of human RISC activation.
Nat.Struct.Mol.Biol., 18, 2011
5IC1
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BU of 5ic1 by Molmil
Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant
分子名称: 1,2-ETHANEDIOL, Talin-1
著者Wu, J, Chang, Y.-C.E, Zhang, H, Huang, Q.-Q.
登録日2016-02-22
公開日2016-05-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration.
Structure, 24, 2016
3PYY
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Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site
分子名称: (5R)-5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]imidazolidine-2,4-dione, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, GLYCEROL, ...
著者Yang, J, Campobasso, N, Biju, M.P, Fisher, K, Pan, X.Q, Cottom, J, Galbraith, S, Ho, T, Zhang, H, Hong, X, Ward, P, Hofmann, G, Siegfried, B.
登録日2010-12-13
公開日2011-03-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site.
Chem.Biol., 18, 2011
1J85
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Structure of YibK from Haemophilus influenzae (HI0766), a truncated sequence homolog of tRNA (guanosine-2'-O-) methyltransferase (SpoU)
分子名称: YibK
著者Lim, K, Zhang, H, Toedt, J, Tempcyzk, A, Krajewski, W, Howard, A, Eisenstein, E, Herzberg, O, Structure 2 Function Project (S2F)
登録日2001-05-20
公開日2003-02-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the YibK methyltransferase from Haemophilus influenzae (HI0766): A cofactor bound at a site formed by a knot
Proteins, 51, 2003

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