3PYY
Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site
Summary for 3PYY
Entry DOI | 10.2210/pdb3pyy/pdb |
Descriptor | V-abl Abelson murine leukemia viral oncogene homolog 1 isoform b variant, SULFATE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (7 entities in total) |
Functional Keywords | tyrosine kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 71871.75 |
Authors | Yang, J.,Campobasso, N.,Biju, M.P.,Fisher, K.,Pan, X.Q.,Cottom, J.,Galbraith, S.,Ho, T.,Zhang, H.,Hong, X.,Ward, P.,Hofmann, G.,Siegfried, B. (deposition date: 2010-12-13, release date: 2011-03-09, Last modification date: 2024-02-21) |
Primary citation | Yang, J.,Campobasso, N.,Biju, M.P.,Fisher, K.,Pan, X.Q.,Cottom, J.,Galbraith, S.,Ho, T.,Zhang, H.,Hong, X.,Ward, P.,Hofmann, G.,Siegfried, B.,Zappacosta, F.,Washio, Y.,Cao, P.,Qu, J.,Bertrand, S.,Wang, D.Y.,Head, M.S.,Li, H.,Moores, S.,Lai, Z.,Johanson, K.,Burton, G.,Erickson-Miller, C.,Simpson, G.,Tummino, P.,Copeland, R.A.,Oliff, A. Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site. Chem.Biol., 18:177-186, 2011 Cited by PubMed: 21338916DOI: 10.1016/j.chembiol.2010.12.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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