Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 4 |
| Chain | Residue |
| A | ARG479 |
| A | GLU481 |
| A | GLY482 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 5 |
| Chain | Residue |
| A | HOH21 |
| A | ARG492 |
| A | GLN496 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE STI A 3 |
| Chain | Residue |
| A | GLU305 |
| A | MET309 |
| A | ILE312 |
| A | VAL318 |
| A | THR334 |
| A | PHE336 |
| A | MET337 |
| A | ILE379 |
| A | HIS380 |
| A | ARG381 |
| A | ALA399 |
| A | ASP400 |
| A | PHE401 |
| A | HOH33 |
| A | ALA288 |
| A | LYS290 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 3YY A 538 |
| Chain | Residue |
| A | HOH150 |
| A | ALA356 |
| A | LEU359 |
| A | ALA363 |
| A | LEU448 |
| A | ILE451 |
| A | ALA452 |
| A | GLU481 |
| A | GLY482 |
| A | CYS483 |
| A | PRO484 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 3 |
| Chain | Residue |
| A | GLU469 |
| A | LYS473 |
| B | LYS313 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE STI B 4 |
| Chain | Residue |
| B | HOH177 |
| B | TYR272 |
| B | LYS290 |
| B | GLU305 |
| B | MET309 |
| B | ILE312 |
| B | VAL318 |
| B | ILE332 |
| B | THR334 |
| B | PHE336 |
| B | MET337 |
| B | ILE379 |
| B | HIS380 |
| B | ALA399 |
| B | ASP400 |
| B | PHE401 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 2PE B 170 |
| Chain | Residue |
| B | ASN355 |
| B | VAL358 |
| B | TYR361 |
| B | ASN393 |
| B | TYR432 |
| B | LYS434 |
| B | PHE516 |
| B | SER520 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 60 |
| Chain | Residue |
| B | HOH37 |
| B | ASP474 |
| B | ARG476 |
| B | ARG492 |
| B | TRP495 |
| B | GLN496 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 3YY B 532 |
| Chain | Residue |
| A | GLU392 |
| A | ASN393 |
| B | HOH152 |
| B | ALA356 |
| B | LEU359 |
| B | ALA363 |
| B | LEU448 |
| B | ILE451 |
| B | ALA452 |
| B | GLU481 |
| B | GLY482 |
| B | CYS483 |
| B | PRO484 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGQYGEVYeGvwkkyslt..........VAVK |
| Chain | Residue | Details |
| A | LEU267-LYS290 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV |
| Chain | Residue | Details |
| A | PHE378-VAL390 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Motif: {"description":"Kinase activation loop"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases","evidences":[{"source":"PubMed","id":"16912036","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P00520","evidenceCode":"ECO:0000250"}]} |
