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3PYY

Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 4
ChainResidue
AARG479
AGLU481
AGLY482

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 5
ChainResidue
AHOH21
AARG492
AGLN496

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE STI A 3
ChainResidue
AGLU305
AMET309
AILE312
AVAL318
ATHR334
APHE336
AMET337
AILE379
AHIS380
AARG381
AALA399
AASP400
APHE401
AHOH33
AALA288
ALYS290

site_idAC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 3YY A 538
ChainResidue
AHOH150
AALA356
ALEU359
AALA363
ALEU448
AILE451
AALA452
AGLU481
AGLY482
ACYS483
APRO484

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 3
ChainResidue
AGLU469
ALYS473
BLYS313

site_idAC6
Number of Residues16
DetailsBINDING SITE FOR RESIDUE STI B 4
ChainResidue
BHOH177
BTYR272
BLYS290
BGLU305
BMET309
BILE312
BVAL318
BILE332
BTHR334
BPHE336
BMET337
BILE379
BHIS380
BALA399
BASP400
BPHE401

site_idAC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 2PE B 170
ChainResidue
BASN355
BVAL358
BTYR361
BASN393
BTYR432
BLYS434
BPHE516
BSER520

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 60
ChainResidue
BHOH37
BASP474
BARG476
BARG492
BTRP495
BGLN496

site_idAC9
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 3YY B 532
ChainResidue
AGLU392
AASN393
BHOH152
BALA356
BLEU359
BALA363
BLEU448
BILE451
BALA452
BGLU481
BGLY482
BCYS483
BPRO484

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGQYGEVYeGvwkkyslt..........VAVK
ChainResidueDetails
ALEU267-LYS290

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV
ChainResidueDetails
APHE378-VAL390

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASP382
BASP382

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING:
ChainResidueDetails
AGLU335
BLEU267
BLYS290
BGLU335
ALEU267
ALYS290

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P42684
ChainResidueDetails
ASER248
BSER248

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR432
BTYR272
BTYR276
BTYR432
ATYR272
ATYR276

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269|PubMed:16912036
ChainResidueDetails
ATYR412
BTYR412

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00520
ChainResidueDetails
ASER465
BSER465

219140

PDB entries from 2024-05-01

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