7MYO
Cryo-EM structure of p110alpha in complex with p85alpha inhibited by BYL-719
Summary for 7MYO
Entry DOI | 10.2210/pdb7myo/pdb |
EMDB information | 24082 |
Descriptor | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide (3 entities in total) |
Functional Keywords | phosphoinositide 3-kinase (pi3k), activation, inhibition, activity-dependent conformational changes, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 211887.25 |
Authors | Liu, X.,Yang, S.,Hart, J.R.,Xu, Y.,Zou, X.,Zhang, H.,Zhou, Q.,Xia, T.,Zhang, Y.,Yang, D.,Wang, M.-W.,Vogt, P.K. (deposition date: 2021-05-21, release date: 2021-11-10, Last modification date: 2024-05-29) |
Primary citation | Liu, X.,Yang, S.,Hart, J.R.,Xu, Y.,Zou, X.,Zhang, H.,Zhou, Q.,Xia, T.,Zhang, Y.,Yang, D.,Wang, M.W.,Vogt, P.K. Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34725156DOI: 10.1073/pnas.2109327118 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.92 Å) |
Structure validation
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