7MYN

Cryo-EM Structure of p110alpha in complex with p85alpha

Summary for 7MYN

• Entry DOI: 10.2210/pdb7myn/pdb
• EMDB information: 24081
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha (3 entities in total)
• Functional Keywords: phosphoinositide 3-kinase (pi3k), activation, inhibition, activity-dependent conformational changes, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 211445.78

Authors

Liu, X.,Yang, S.,Hart, J.R.,Xu, Y.,Zou, X.,Zhang, H.,Zhou, Q.,Xia, T.,Zhang, Y.,Yang, D.,Wang, M.-W.,Vogt, P.K. (deposition date: 2021-05-21, release date: 2021-11-10, Last modification date: 2021-11-17)

• Primary citation: Liu, X.,Yang, S.,Hart, J.R.,Xu, Y.,Zou, X.,Zhang, H.,Zhou, Q.,Xia, T.,Zhang, Y.,Yang, D.,Wang, M.W.,Vogt, P.K.; Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34725156; DOI: 10.1073/pnas.2109327118

Experimental method

ELECTRON MICROSCOPY (2.79 Å)