6IVP
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![BU of 6ivp by Molmil](/molmil-images/mine/6ivp) | Crystal structure of a membrane protein P262A | 分子名称: | CHLORIDE ION, ZINC ION, bestrophin | 著者 | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | 登録日 | 2018-12-04 | 公開日 | 2019-11-06 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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6IVN
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![BU of 6ivn by Molmil](/molmil-images/mine/6ivn) | Crystal structure of a membrane protein G264A | 分子名称: | CHLORIDE ION, GLUTAMIC ACID, Ibestrophin, ... | 著者 | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | 登録日 | 2018-12-04 | 公開日 | 2019-11-06 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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6IV2
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6IVL
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![BU of 6ivl by Molmil](/molmil-images/mine/6ivl) | Crystal structure of a membrane protein L259A | 分子名称: | ACETIC ACID, CHLORIDE ION, Ibestrophin, ... | 著者 | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | 登録日 | 2018-12-04 | 公開日 | 2019-11-06 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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6IVJ
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![BU of 6ivj by Molmil](/molmil-images/mine/6ivj) | Crystal structure of a membrane protein G18A | 分子名称: | ACETIC ACID, CHLORIDE ION, Ibestrophin, ... | 著者 | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | 登録日 | 2018-12-04 | 公開日 | 2019-11-06 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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8ECY
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![BU of 8ecy by Molmil](/molmil-images/mine/8ecy) | cryoEM structure of bovine bestrophin-2 and glutamine synthetase complex | 分子名称: | Bestrophin, CALCIUM ION, CHLORIDE ION, ... | 著者 | Owji, A.P, Kittredge, A.K, Yang, T. | 登録日 | 2022-09-02 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2 Å) | 主引用文献 | Bestrophin-2 and glutamine synthetase form a complex for glutamate release. Nature, 611, 2022
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7VPG
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![BU of 7vpg by Molmil](/molmil-images/mine/7vpg) | Crystal structure of the C-terminal tail of SARS-CoV-1 Orf6 complex with human nucleoporin pair Rae1-Nup98 | 分子名称: | Isoform 3 of Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor | 著者 | Li, T, Guo, H, Yang, T, Wen, Y, Ji, X. | 登録日 | 2021-10-17 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export. Front Mol Biosci, 8, 2021
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7VPH
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![BU of 7vph by Molmil](/molmil-images/mine/7vph) | Crystal structure of the C-terminal tail of SARS-CoV-2 Orf6 complex with human nucleoporin pair Rae1-Nup98 | 分子名称: | Isoform 3 of Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor | 著者 | Li, T, Guo, H, Yang, T, Wen, Y, Ji, X. | 登録日 | 2021-10-17 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export. Front Mol Biosci, 8, 2021
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7X1Z
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![BU of 7x1z by Molmil](/molmil-images/mine/7x1z) | Structure of the phosphorylation-site double mutant S431E/T432E of the KaiC circadian clock protein | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock oscillator protein KaiC, MAGNESIUM ION | 著者 | Han, X, Zhang, D.L, Hong, L, Yu, D.Q, Wu, Z.L, Yang, T, Rust, M.J, Tu, Y.H, Ouyang, Q. | 登録日 | 2022-02-25 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex Nat Commun, 14, 2023
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7YG7
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![BU of 7yg7 by Molmil](/molmil-images/mine/7yg7) | Structure of the Spring Viraemia of Carp Virus ribonucleoprotein Complex | 分子名称: | Nucleoprotein, RNA (99-mer) | 著者 | Liu, B, Wang, Z.X, Yang, T, Yu, D.Q, Ouyang, Q. | 登録日 | 2022-07-11 | 公開日 | 2023-03-15 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of the Spring Viraemia of Carp Virus Ribonucleoprotein Complex Reveals Its Assembly Mechanism and Application in Antiviral Drug Screening. J.Virol., 97, 2023
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7X1Y
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![BU of 7x1y by Molmil](/molmil-images/mine/7x1y) | Structure of the phosphorylation-site double mutant S431A/T432A of the KaiC circadian clock protein | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock oscillator protein KaiC, MAGNESIUM ION | 著者 | Han, X, Zhang, D.L, Hong, L, Yu, D.Q, Wu, Z.L, Yang, T, Rust, M.J, Tu, Y.H, Ouyang, Q. | 登録日 | 2022-02-25 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex Nat Commun, 14, 2023
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6VX7
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![BU of 6vx7 by Molmil](/molmil-images/mine/6vx7) | bestrophin-2 Ca2+-bound state (5 mM Ca2+) | 分子名称: | Bestrophin, CALCIUM ION, CHLORIDE ION | 著者 | Owji, A.P, Zhao, Q, Ji, C, Kittredge, A, Hopiavuori, A, Fu, Z, Ward, N, Clarke, O, Shen, Y, Zhang, Y, Hendrickson, W.A, Yang, T. | 登録日 | 2020-02-21 | 公開日 | 2020-04-08 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.36 Å) | 主引用文献 | Structural and functional characterization of the bestrophin-2 anion channel. Nat.Struct.Mol.Biol., 27, 2020
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1ZVM
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![BU of 1zvm by Molmil](/molmil-images/mine/1zvm) | Crystal structure of human CD38: cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase | 分子名称: | ADP-ribosyl cyclase 1, SULFATE ION | 著者 | Shi, W, Yang, T, Almo, S.C, Schramm, V.L, Sauve, A. | 登録日 | 2005-06-02 | 公開日 | 2006-06-06 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of human CD38: Cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase To be Published
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7DFT
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![BU of 7dft by Molmil](/molmil-images/mine/7dft) | Crystal structure of Xanthomonas oryzae ClpP | 分子名称: | ATP-dependent Clp protease proteolytic subunit, CHLORIDE ION | 著者 | Yang, C.-G, Yang, T. | 登録日 | 2020-11-09 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections. J.Agric.Food Chem., 69, 2021
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7DFU
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5OCV
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![BU of 5ocv by Molmil](/molmil-images/mine/5ocv) | A Rare Lysozyme Crystal Form Solved Using High-Redundancy 3D Electron Diffraction Data from Micron-Sized Needle Shaped Crystals | 分子名称: | Lysozyme C, SODIUM ION | 著者 | Xu, H, Lebrette, H, Yang, T, Srinivas, V, Hovmoller, S, Hogbom, M, Zou, X. | 登録日 | 2017-07-03 | 公開日 | 2018-03-28 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.2 Å) | 主引用文献 | A Rare Lysozyme Crystal Form Solved Using Highly Redundant Multiple Electron Diffraction Datasets from Micron-Sized Crystals. Structure, 26, 2018
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5X87
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6JLF
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![BU of 6jlf by Molmil](/molmil-images/mine/6jlf) | |
7DCY
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![BU of 7dcy by Molmil](/molmil-images/mine/7dcy) | Apo form of Mycoplasma genitalium RNase R | 分子名称: | MAGNESIUM ION, Ribonuclease R | 著者 | Abula, A, Quan, X, Li, X, Yang, T, Li, T, Chen, Q, Ji, X. | 登録日 | 2020-10-27 | 公開日 | 2021-03-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.972 Å) | 主引用文献 | Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation. Nucleic Acids Res., 49, 2021
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7DIC
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![BU of 7dic by Molmil](/molmil-images/mine/7dic) | Mycoplasma genitalium RNase R in complex with single-stranded RNA | 分子名称: | MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), Ribonuclease R | 著者 | Abula, A, Quan, X, Li, X, Yang, T, Li, T, Chen, Q, Ji, X. | 登録日 | 2020-11-18 | 公開日 | 2021-03-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.242 Å) | 主引用文献 | Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation. Nucleic Acids Res., 49, 2021
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7DOL
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![BU of 7dol by Molmil](/molmil-images/mine/7dol) | Mycoplasma genitalium RNase R in complex with double-stranded RNA | 分子名称: | MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*AP*AP*A)-3'), Ribonuclease R | 著者 | Abula, A, Quan, X, Li, X, Yang, T, Li, T, Chen, Q, Ji, X. | 登録日 | 2020-12-14 | 公開日 | 2021-03-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation. Nucleic Acids Res., 49, 2021
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7DID
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![BU of 7did by Molmil](/molmil-images/mine/7did) | Mycoplasma genitalium RNase R in complex with ribose methylated single-stranded RNA | 分子名称: | MAGNESIUM ION, RNA (5'-R(*AP*AP*AP*A)-3'), Ribonuclease R | 著者 | Abula, A, Quan, X, Li, X, Yang, T, Li, T, Chen, Q, Ji, X. | 登録日 | 2020-11-18 | 公開日 | 2021-03-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation. Nucleic Acids Res., 49, 2021
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5YL2
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![BU of 5yl2 by Molmil](/molmil-images/mine/5yl2) | Crystal structure of T2R-TTL-Y28 complex | 分子名称: | (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxy-3-oxidanyl-phenyl)prop-2-en-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Yang, J.H, Yang, T, Wen, J.L, Chen, L.J. | 登録日 | 2017-10-16 | 公開日 | 2018-04-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 2018
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4RZE
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![BU of 4rze by Molmil](/molmil-images/mine/4rze) | Crystal Structure Analysis of the NUR77 Ligand Binding Domain, L437W,D594E mutant | 分子名称: | GLYCEROL, Nuclear receptor subfamily 4 group A member 1 | 著者 | Fengwei, L, Xuyang, T, Anzhong, L, Li, L, Yuan, L, Hangzi, C, Qiao, W, Tianwei, L. | 登録日 | 2014-12-21 | 公開日 | 2015-03-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol., 11, 2015
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8JFC
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![BU of 8jfc by Molmil](/molmil-images/mine/8jfc) | V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 6 (B21591), NADPH and dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 4-[3-[[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]methyl]phenyl]benzoic acid, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | 著者 | Vanichtanankul, J, Saeyang, T, Vitsupakorn, D, Saepua, S, Thongpanchang, C, Yuthavong, Y, Kamchonwongpaisan, S, Hoarau, M. | 登録日 | 2023-05-17 | 公開日 | 2023-08-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of rigid biphenyl Plasmodium falciparum DHFR inhibitors using a fragment linking strategy. Rsc Med Chem, 14, 2023
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