8JFC
V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 6 (B21591), NADPH and dUMP
Summary for 8JFC
| Entry DOI | 10.2210/pdb8jfc/pdb |
| Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (6 entities in total) |
| Functional Keywords | dhfr, dihydrofolate reductase, plasmodium falciparum, malaria, oxidoreductase |
| Biological source | Plasmodium falciparum (malaria parasite P. falciparum) |
| Total number of polymer chains | 2 |
| Total formula weight | 146804.46 |
| Authors | Vanichtanankul, J.,Saeyang, T.,Vitsupakorn, D.,Saepua, S.,Thongpanchang, C.,Yuthavong, Y.,Kamchonwongpaisan, S.,Hoarau, M. (deposition date: 2023-05-17, release date: 2023-08-23, Last modification date: 2023-10-04) |
| Primary citation | Hoarau, M.,Sermmai, P.,Varatthan, T.,Thiabma, R.,Jantra, T.,Rattanajak, R.,Vitsupakorn, D.,Vanichtanankul, J.,Saepua, S.,Yuthavong, Y.,Thongpanchang, C.,Kamchonwongpaisan, S. Discovery of rigid biphenyl Plasmodium falciparum DHFR inhibitors using a fragment linking strategy. Rsc Med Chem, 14:1755-1766, 2023 Cited by PubMed: 37731689DOI: 10.1039/d3md00242j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report
