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5YL2

Crystal structure of T2R-TTL-Y28 complex

Summary for 5YL2
Entry DOI10.2210/pdb5yl2/pdb
DescriptorTubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxy-3-oxidanyl-phenyl)prop-2-en-1-one, ... (13 entities in total)
Functional Keywordscolchicine binding domain, tubulin inhibitor, tublin, millepachine, structural protein
Biological sourceSus scrofa (Pig)
More
Cellular locationCytoplasm, cytoskeleton: Q2XVP4 A0A287AGU7
Golgi apparatus : P63043
Total number of polymer chains6
Total formula weight265346.79
Authors
Yang, J.H.,Yang, T.,Wen, J.L.,Chen, L.J. (deposition date: 2017-10-16, release date: 2018-04-18, Last modification date: 2024-03-27)
Primary citationJianhong, Y.,Wei, Y.,Yamei, Y.,Yuxi, W.,Tao, Y.,Linlin, X.,Xue, Y.,Caofeng, L.,Zuowei, L.,Xiaoxin, C.,Mengshi, H.,Li, Z.,Qiang, Q.,Heying, P.,Dan, L.,Fang, W.,Peng, B.,Jiaolin, W.,Haoyu, Y.,Lijuan, C.
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 2018
Cited by
PubMed: 29691282
DOI: 10.1074/jbc.RA117.001658
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.09 Å)
Structure validation

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