8DD9
 
 | | Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144L Mutant in Complex with Inhibitor GC376 | | Descriptor: | (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | | Authors: | Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y. | | Deposit date: | 2022-06-17 | | Release date: | 2022-07-13 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir.
Acs Cent.Sci., 9, 2023
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2JWS
 | | Solution NMR structures of two designed proteins with 88% sequence identity but different fold and function | | Descriptor: | Ga88 | | Authors: | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | | Deposit date: | 2007-10-24 | | Release date: | 2008-09-09 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | NMR structures of two designed proteins with high sequence identity but different fold and function
Proc.Natl.Acad.Sci.Usa, 105, 2008
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5VLE
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8Y22
 | | FGFR1 kinase domain with a covalent inhibitor 9g | | Descriptor: | Fibroblast growth factor receptor 1, SULFATE ION, ~{N}-[4-[[4-azanyl-3-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]phenyl]propanamide | | Authors: | Chen, X.J, Chen, Y.H. | | Deposit date: | 2024-01-25 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (2.792 Å) | | Cite: | Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors.
Eur.J.Med.Chem., 275, 2024
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8XZ7
 | | FGFR1 kinase domain with a covalent inhibitor 10h | | Descriptor: | 5-azanyl-3-[2-[4,6-bis(fluoranyl)-2-methyl-3~{H}-benzimidazol-5-yl]ethynyl]-1-[[3-(prop-2-enoylamino)phenyl]methyl]pyrazole-4-carboxamide, Fibroblast growth factor receptor 1, SULFATE ION | | Authors: | Chen, X.J, Chen, Y.H. | | Deposit date: | 2024-01-20 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors.
Eur.J.Med.Chem., 275, 2024
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5U4J
 | | Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S12, ... | | Authors: | Zeng, F, Chen, Y, Remis, J, Shekhar, M, Phillips, J.C, Tajkhorshid, E, Jin, H. | | Deposit date: | 2016-12-04 | | Release date: | 2017-01-11 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome.
Nature, 541, 2017
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5WFI
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5TOP
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3QFN
 | | Crystal structure of Streptococcal asymmetric Ap4A hydrolase and phosphodiesterase Spr1479/SapH in complex with inorganic phosphate | | Descriptor: | FE (III) ION, MANGANESE (II) ION, PHOSPHATE ION, ... | | Authors: | Jiang, Y.L, Zhang, J.W, Yu, W.L, Cheng, W, Zhang, C.C, Zhou, C.Z, Chen, Y. | | Deposit date: | 2011-01-22 | | Release date: | 2011-08-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Structural and enzymatic characterization of a Streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH
To be Published
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2JWU
 | | Solution NMR structures of two designed proteins with 88% sequence identity but different fold and function | | Descriptor: | Gb88 | | Authors: | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | | Deposit date: | 2007-10-25 | | Release date: | 2008-09-09 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | NMR structures of two designed proteins with high sequence identity but different fold and function
Proc.Natl.Acad.Sci.Usa, 105, 2008
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5UJ4
 | | Crystal structure of the KPC-2 beta-lactamase complexed with hydrolyzed faropenem | | Descriptor: | (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL | | Authors: | Pemberton, O.A, Chen, Y. | | Deposit date: | 2017-01-16 | | Release date: | 2017-04-26 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).
J. Med. Chem., 60, 2017
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5UM6
 | | Crystal Structure of S. pombe Uba1 in a closed conformation | | Descriptor: | 2-(decylamino)ethane-1-thiol, N-(2-{[(4-chlorophenyl)methyl]disulfanyl}ethyl)decan-1-amine, SULFATE ION, ... | | Authors: | Lv, Z, Yuan, L, Aldana-Masangkay, G, Atkison, J.H, Chen, Y, Olsen, S.K. | | Deposit date: | 2017-01-26 | | Release date: | 2017-06-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.794 Å) | | Cite: | Domain alternation and active site remodeling are conserved structural features of ubiquitin E1.
J. Biol. Chem., 292, 2017
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4I5W
 | | Crystal structure of yeast Ap4A phosphorylase Apa2 in complex with AMP | | Descriptor: | 5',5'''-P-1,P-4-tetraphosphate phosphorylase 2, ADENOSINE MONOPHOSPHATE, PHOSPHATE ION | | Authors: | Jiang, Y.L, Hou, W.T, Chen, Y, Zhou, C.Z. | | Deposit date: | 2012-11-29 | | Release date: | 2013-05-08 | | Last modified: | 2014-02-05 | | Method: | X-RAY DIFFRACTION (2.793 Å) | | Cite: | Structures of yeast Apa2 reveal catalytic insights into a canonical AP4A phosphorylase of the histidine triad superfamily
J.Mol.Biol., 425, 2013
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5WQD
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3QFO
 | | Crystal structure of Streptococcal asymmetric Ap4A hydrolase and phosphodiesterase Spr1479/SapH im complex with AMP | | Descriptor: | ADENOSINE MONOPHOSPHATE, FE (III) ION, MANGANESE (II) ION, ... | | Authors: | Jiang, Y.L, Zhang, J.W, Yu, W.L, Cheng, W, Zhang, C.C, Zhou, C.Z, Chen, Y. | | Deposit date: | 2011-01-22 | | Release date: | 2011-08-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural and enzymatic characterization of a Streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH
To be Published
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3QFM
 | | Crystal structure of Streptococcal asymmetric Ap4A hydrolase and phosphodiesterase Spr1479/SapH | | Descriptor: | FE (III) ION, MANGANESE (II) ION, Putative uncharacterized protein | | Authors: | Jiang, Y.L, Zhang, J.W, Yu, W.L, Cheng, W, Zhang, C.C, Zhou, C.Z, Chen, Y. | | Deposit date: | 2011-01-22 | | Release date: | 2011-08-24 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and enzymatic characterization of a Streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH
To be Published
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4N4Y
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6LR0
 | | structure of human bile salt exporter ABCB11 | | Descriptor: | Bile salt export pump | | Authors: | Wang, L, Hou, W.T, Chen, L, Jiang, Y.L, Xu, D, Sun, L.F, Zhou, C.Z, Chen, Y. | | Deposit date: | 2020-01-15 | | Release date: | 2020-04-15 | | Last modified: | 2023-01-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM structure of human bile salts exporter ABCB11.
Cell Res., 30, 2020
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3TEF
 | | Crystal Structure of the Periplasmic Catecholate-Siderophore Binding Protein VctP from Vibrio Cholerae | | Descriptor: | Iron(III) ABC transporter, periplasmic iron-compound-binding protein | | Authors: | Liu, X, Wang, Z, Liu, S, Li, N, Chen, Y, Zhu, C, Zhu, D, Wei, T, Huang, Y, Xu, S, Gu, L. | | Deposit date: | 2011-08-13 | | Release date: | 2012-08-15 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.698 Å) | | Cite: | Crystal structure of periplasmic catecholate-siderophore binding protein VctP from Vibrio cholerae at 1.7 A resolution
Febs Lett., 586, 2012
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4PAS
 | | Heterodimeric coiled-coil structure of human GABA(B) receptor | | Descriptor: | Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2 | | Authors: | Burmakina, S, Geng, Y, Chen, Y, Fan, Q.R. | | Deposit date: | 2014-04-10 | | Release date: | 2014-05-07 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Heterodimeric coiled-coil interactions of human GABAB receptor.
Proc.Natl.Acad.Sci.USA, 111, 2014
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5H4P
 | | Structural snapshot of cytoplasmic pre-60S ribosomal particles bound with Nmd3, Lsg1, Tif6 and Reh1 | | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Ma, C, Wu, S, Li, N, Chen, Y, Yan, K, Li, Z, Zheng, L, Lei, J, Woolford, J.L, Gao, N. | | Deposit date: | 2016-11-01 | | Release date: | 2017-01-25 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1
Nat. Struct. Mol. Biol., 24, 2017
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4Q9V
 | | Crystal structure of TIPE3 | | Descriptor: | CHLORIDE ION, SULFATE ION, Tumor necrosis factor alpha-induced protein 8-like protein 3 | | Authors: | Wu, J, Zhang, X, Chen, Y.H, Shi, Y. | | Deposit date: | 2014-05-02 | | Release date: | 2014-10-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer.
Cancer Cell, 26, 2014
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3SF5
 | | Crystal Structure of Helicobacter pylori Urease Accessory Protein UreF/H complex | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, SULFATE ION, ... | | Authors: | Fong, Y.H, Chen, Y.W, Wong, K.B. | | Deposit date: | 2011-06-12 | | Release date: | 2011-11-02 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.495 Å) | | Cite: | Assembly of preactivation complex for urease maturation in Helicobacter pylori: crystal structure of UreF-UreH protein complex
J.Biol.Chem., 286, 2011
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4Q2V
 | | Crystal Structure of Ricin A chain complexed with Baicalin inhibitor | | Descriptor: | 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, Ricin | | Authors: | Deng, X, Li, X, Dong, J, Chen, Y. | | Deposit date: | 2014-04-10 | | Release date: | 2015-04-15 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.198 Å) | | Cite: | Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization.
J.Biol.Chem., 290, 2015
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2OA5
 | | Crystal structure of ORF52 from Murid herpesvirus (MUHV-4) (Murine gammaherpesvirus 68) at 2.1 A resolution. Northeast Structural Genomics Consortium target MHR28B. | | Descriptor: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Hypothetical protein BQLF2 | | Authors: | Benach, J, Chen, Y, Seetharaman, J, Janjua, H, Xiao, R, Cunningham, K, Ma, L.-C, Ho, C.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2006-12-14 | | Release date: | 2007-01-30 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus 68.
J.Biol.Chem., 282, 2007
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