6DNE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dne by Molmil](/molmil-images/mine/6dne) | Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS660 | Descriptor: | Bromodomain-containing protein 4, N,N'-[ethane-1,2-diylbis(oxyethane-2,1-diyl)]bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide} | Authors: | Ren, C, Zhou, M.M. | Deposit date: | 2018-06-06 | Release date: | 2018-07-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.958 Å) | Cite: | Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
6DJC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6djc by Molmil](/molmil-images/mine/6djc) | Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS645 | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N,N'-(decane-1,10-diyl)bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide} | Authors: | Ren, C, Zhou, M.M. | Deposit date: | 2018-05-25 | Release date: | 2018-07-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
3KMA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3kma by Molmil](/molmil-images/mine/3kma) | Crystal Structure of vSET under Condition A | Descriptor: | A612L protein, CHLORIDE ION, GLYCEROL, ... | Authors: | Wei, H, Zhou, M.M. | Deposit date: | 2009-11-10 | Release date: | 2010-11-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Dimerization of a viral SET protein endows its function. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
6DUV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6duv by Molmil](/molmil-images/mine/6duv) | Crystal structure of the second bromodomain of human BRD4 in complex with MS417 inhibitor | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate | Authors: | Babault, N, Zhou, M.M. | Deposit date: | 2018-06-22 | Release date: | 2019-06-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Role of Bound Water Molecules in Differential Recognition of Di-Acetylated Histone Peptides by the BRD4 Bromodomains To be published
|
|
1SZV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1szv by Molmil](/molmil-images/mine/1szv) | Structure of the Adaptor Protein p14 reveals a Profilin-like Fold with Novel Function | Descriptor: | Late endosomal/lysosomal Mp1 interacting protein | Authors: | Qian, C, Zhang, Q, Wang, X, Zeng, L, Farooq, A, Zhou, M.M. | Deposit date: | 2004-04-06 | Release date: | 2005-03-15 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of the Adaptor Protein p14 Reveals a Profilin-like Fold with Distinct Function J.Mol.Biol., 347, 2005
|
|
2D82
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2d82 by Molmil](/molmil-images/mine/2d82) | Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association | Descriptor: | 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE, CREB-binding protein | Authors: | Sachchidanand, Resnick-Silverman, L, Yan, S, Mujtaba, S, Liu, W.J, Zeng, L, Manfredi, J.J, Zhou, M.M. | Deposit date: | 2005-12-01 | Release date: | 2006-04-04 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Target structure-based discovery of small molecules that block human p53 and CREB binding protein association Chem.Biol., 13, 2006
|
|
2RNW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rnw by Molmil](/molmil-images/mine/2rnw) | The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the Human Transcriptional Co-Activators PCAf and CBP | Descriptor: | Histone H3, Histone acetyltransferase PCAF | Authors: | Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M. | Deposit date: | 2008-02-03 | Release date: | 2008-05-06 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300 Structure, 16, 2008
|
|
2RNX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rnx by Molmil](/molmil-images/mine/2rnx) | The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the HUman Transcriptional Co-Activators PCAF and CBP | Descriptor: | Histone H3, Histone acetyltransferase PCAF | Authors: | Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M. | Deposit date: | 2008-02-03 | Release date: | 2008-05-06 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300 Structure, 16, 2008
|
|
2RNY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rny by Molmil](/molmil-images/mine/2rny) | Complex Structures of CBP Bromodomain with H4 ack20 Peptide | Descriptor: | CREB-binding protein, Histone H4 | Authors: | Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M. | Deposit date: | 2008-02-03 | Release date: | 2008-05-06 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300 Structure, 16, 2008
|
|
1WUG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1wug by Molmil](/molmil-images/mine/1wug) | complex structure of PCAF bromodomain with small chemical ligand NP1 | Descriptor: | Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE | Authors: | Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M. | Deposit date: | 2004-12-07 | Release date: | 2005-08-16 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Selective small molecules blocking HIV-1 Tat and coactivator PCAF association J.Am.Chem.Soc., 127, 2005
|
|
1WUM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1wum by Molmil](/molmil-images/mine/1wum) | Complex structure of PCAF bromodomain with small chemical ligand NP2 | Descriptor: | Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE | Authors: | Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M. | Deposit date: | 2004-12-08 | Release date: | 2005-08-16 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Selective small molecules blocking HIV-1 Tat and coactivator PCAF association J.Am.Chem.Soc., 127, 2005
|
|
3KMT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3kmt by Molmil](/molmil-images/mine/3kmt) | Crystal structure of vSET/SAH/H3 ternary complex | Descriptor: | A612L protein, Histone H3, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Wei, H, Zhou, M.M. | Deposit date: | 2009-11-11 | Release date: | 2010-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Dimerization of a viral SET protein endows its function. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3KMJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3kmj by Molmil](/molmil-images/mine/3kmj) | Crystal structure of vSET under condition B | Descriptor: | A612L protein, SULFATE ION | Authors: | Wei, H, Zhou, M.M. | Deposit date: | 2009-11-10 | Release date: | 2010-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Dimerization of a viral SET protein endows its function. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3LJW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ljw by Molmil](/molmil-images/mine/3ljw) | Crystal Structure of the Second Bromodomain of Human Polybromo | Descriptor: | ACETATE ION, Protein polybromo-1, SODIUM ION | Authors: | Charlop-Powers, Z, Zhou, M.M, Zeng, L, Zhang, Q. | Deposit date: | 2010-01-26 | Release date: | 2010-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2. Cell Res., 20, 2010
|
|
5EJW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ejw by Molmil](/molmil-images/mine/5ejw) | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351 | Descriptor: | (1~{R})-2-[2-azanylidene-3-[(2-methylphenyl)methyl]benzimidazol-1-yl]-1-(3,4-dichlorophenyl)ethanol, Chromobox protein homolog 7 | Authors: | Ren, C, Zhou, M.M. | Deposit date: | 2015-11-02 | Release date: | 2016-03-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7. Acs Med.Chem.Lett., 7, 2016
|
|
4X3T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4x3t by Molmil](/molmil-images/mine/4x3t) | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS37452 | Descriptor: | 1,2-ETHANEDIOL, 1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone, Chromobox protein homolog 7, ... | Authors: | Ren, C, Jakoncic, J, Zhou, M.M. | Deposit date: | 2014-12-01 | Release date: | 2015-03-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. Chem.Biol., 22, 2015
|
|
2G46
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2g46 by Molmil](/molmil-images/mine/2g46) | |
4X3K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4x3k by Molmil](/molmil-images/mine/4x3k) | |
4X3U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4x3u by Molmil](/molmil-images/mine/4x3u) | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with Suramin | Descriptor: | 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, Chromobox protein homolog 7 | Authors: | Ren, C, Zhou, M.M. | Deposit date: | 2014-12-01 | Release date: | 2015-03-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. Chem.Biol., 22, 2015
|
|
4X3S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4x3s by Molmil](/molmil-images/mine/4x3s) | Crystal structure of chromobox homology 7 (CBX7) with SETDB1-1170me3 Peptide | Descriptor: | CITRIC ACID, Chromobox protein homolog 7, FE (III) ION, ... | Authors: | Ren, C, Plotnikov, A.N, Zhou, M.M. | Deposit date: | 2014-12-01 | Release date: | 2015-03-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. Chem.Biol., 22, 2015
|
|