6DUV
Crystal structure of the second bromodomain of human BRD4 in complex with MS417 inhibitor
Summary for 6DUV
Entry DOI | 10.2210/pdb6duv/pdb |
Descriptor | Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | protein-small molecule inhibitor complex, protein binding, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 27753.54 |
Authors | Babault, N.,Zhou, M.M. (deposition date: 2018-06-22, release date: 2019-06-26, Last modification date: 2024-03-13) |
Primary citation | Babault, N.,Zhang, Q.,Zhang, G.,Zhou, M.M.,Zeng, L. Role of Bound Water Molecules in Differential Recognition of Di-Acetylated Histone Peptides by the BRD4 Bromodomains To be published, |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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