6DUV

Crystal structure of the second bromodomain of human BRD4 in complex with MS417 inhibitor

Summary for 6DUV

• Entry DOI: 10.2210/pdb6duv/pdb
• Descriptor: Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: protein-small molecule inhibitor complex, protein binding, protein binding-inhibitor complex, protein binding/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 27753.54

Authors

Babault, N.,Zhou, M.M. (deposition date: 2018-06-22, release date: 2019-06-26, Last modification date: 2024-03-13)

• Primary citation: Babault, N.,Zhang, Q.,Zhang, G.,Zhou, M.M.,Zeng, L.; Role of Bound Water Molecules in Differential Recognition of Di-Acetylated Histone Peptides by the BRD4 Bromodomains; To be published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)