The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the Human Transcriptional Co-Activators PCAf and CBP

Summary for 2RNW

DescriptorHistone acetyltransferase PCAF, Histone H3 (2 entities in total)
Functional Keywordsbromodomain, histone, acetyltransferase, acyltransferase, cell cycle, host-virus interaction, nucleus, polymorphism, transcription, transcription regulation, acetylation, chromosomal protein, dna damage, dna repair, dna-binding, methylation, nucleosome core, phosphoprotein, transferase-nuclear protein complex, transferase/nuclear protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus (By similarity) Q92831
Nucleus P61830
Total number of polymer chains2
Total molecular weight15659.05
Zeng, L.,Zhang, Q.,Gerona-Navarro, G.,Zhou, M.M. (deposition date: 2008-02-03, release date: 2008-05-06, Last modification date: 2011-07-13)
Primary citation
Zeng, L.,Zhang, Q.,Gerona-Navarro, G.,Moshkina, N.,Zhou, M.M.
Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300
Structure, 16:643-652, 2008
PubMed: 18400184 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2008.01.010
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers81 5.1% 27.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
PDB entries from 2020-10-21