6DJC
Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS645
Summary for 6DJC
Entry DOI | 10.2210/pdb6djc/pdb |
Descriptor | Bromodomain-containing protein 4, N,N'-(decane-1,10-diyl)bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide}, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | transcription, inhibitor, histone acetylation, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 32808.81 |
Authors | Ren, C.,Zhou, M.M. (deposition date: 2018-05-25, release date: 2018-07-25, Last modification date: 2023-10-11) |
Primary citation | Ren, C.,Zhang, G.,Han, F.,Fu, S.,Cao, Y.,Zhang, F.,Zhang, Q.,Meslamani, J.,Xu, Y.,Ji, D.,Cao, L.,Zhou, Q.,Cheung, K.L.,Sharma, R.,Babault, N.,Yi, Z.,Zhang, W.,Walsh, M.J.,Zeng, L.,Zhou, M.M. Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth. Proc. Natl. Acad. Sci. U.S.A., 115:7949-7954, 2018 Cited by PubMed: 30012592DOI: 10.1073/pnas.1720000115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
Download full validation report