6DNE

Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS660

Summary for 6DNE

Entry DOI	10.2210/pdb6dne/pdb
Descriptor	Bromodomain-containing protein 4, N,N'-[ethane-1,2-diylbis(oxyethane-2,1-diyl)]bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide} (3 entities in total)
Functional Keywords	transcription, inhibitor, histone acetylation
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	98397.86
Authors	Ren, C.,Zhou, M.M. (deposition date: 2018-06-06, release date: 2018-07-18, Last modification date: 2023-10-11)
Primary citation	Ren, C.,Zhang, G.,Han, F.,Fu, S.,Cao, Y.,Zhang, F.,Zhang, Q.,Meslamani, J.,Xu, Y.,Ji, D.,Cao, L.,Zhou, Q.,Cheung, K.L.,Sharma, R.,Babault, N.,Yi, Z.,Zhang, W.,Walsh, M.J.,Zeng, L.,Zhou, M.M. Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth. Proc. Natl. Acad. Sci. U.S.A., 115:7949-7954, 2018 Cited by PubMed: 30012592 DOI: 10.1073/pnas.1720000115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.958 Å)

Structure validation